209 related articles for article (PubMed ID: 31812637)
1. Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.
Esposito F; Sechi M; Pala N; Sanna A; Koneru PC; Kvaratskhelia M; Naesens L; Corona A; Grandi N; di Santo R; D'Amore VM; Di Leva FS; Novellino E; Cosconati S; Tramontano E
Antiviral Res; 2020 Feb; 174():104671. PubMed ID: 31812637
[TBL] [Abstract][Full Text] [Related]
2. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Patel D; Antwi J; Koneru PC; Serrao E; Forli S; Kessl JJ; Feng L; Deng N; Levy RM; Fuchs JR; Olson AJ; Engelman AN; Bauman JD; Kvaratskhelia M; Arnold E
J Biol Chem; 2016 Nov; 291(45):23569-23577. PubMed ID: 27645997
[TBL] [Abstract][Full Text] [Related]
3. Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
Esposito F; Ambrosio FA; Maleddu R; Costa G; Rocca R; Maccioni E; Catalano R; Romeo I; Eleftheriou P; Karia DC; Tsirides P; Godvani N; Pandya H; Corona A; Alcaro S; Artese A; Geronikaki A; Tramontano E
Eur J Med Chem; 2019 Nov; 182():111617. PubMed ID: 31442684
[TBL] [Abstract][Full Text] [Related]
4. Molecular Docking and Molecular Dynamics Simulation Based Approach to Explore the Dual Inhibitor Against HIV-1 Reverse Transcriptase and Integrase.
Chander S; Pandey RK; Penta A; Choudhary BS; Sharma M; Malik R; Prajapati VK; Murugesan S
Comb Chem High Throughput Screen; 2017; 20(8):734-746. PubMed ID: 28641512
[TBL] [Abstract][Full Text] [Related]
5. Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.
Yang F; Zheng G; Fu T; Li X; Tu G; Li YH; Yao X; Xue W; Zhu F
Phys Chem Chem Phys; 2018 Sep; 20(37):23873-23884. PubMed ID: 29947629
[TBL] [Abstract][Full Text] [Related]
6. New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.
Corona A; di Leva FS; Rigogliuso G; Pescatori L; Madia VN; Subra F; Delelis O; Esposito F; Cadeddu M; Costi R; Cosconati S; Novellino E; di Santo R; Tramontano E
Antiviral Res; 2016 Oct; 134():236-243. PubMed ID: 27659398
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
Cuzzucoli Crucitti G; Métifiot M; Pescatori L; Messore A; Madia VN; Pupo G; Saccoliti F; Scipione L; Tortorella S; Esposito F; Corona A; Cadeddu M; Marchand C; Pommier Y; Tramontano E; Costi R; Di Santo R
J Med Chem; 2015 Feb; 58(4):1915-28. PubMed ID: 25629256
[TBL] [Abstract][Full Text] [Related]
8. 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.
Sun L; Gao P; Dong G; Zhang X; Cheng X; Ding X; Wang X; Daelemans D; De Clercq E; Pannecouque C; Menéndez-Arias L; Zhan P; Liu X
Eur J Med Chem; 2018 Jul; 155():714-724. PubMed ID: 29940462
[TBL] [Abstract][Full Text] [Related]
9. Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
Wang L; Sarafianos SG; Wang Z
Acc Chem Res; 2020 Jan; 53(1):218-230. PubMed ID: 31880912
[TBL] [Abstract][Full Text] [Related]
10. Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors.
Esposito F; Tramontano E
Antivir Chem Chemother; 2014 Jan; 23(4):129-44. PubMed ID: 24150519
[TBL] [Abstract][Full Text] [Related]
11. Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
Corona A; Meleddu R; Esposito F; Distinto S; Bianco G; Masaoka T; Maccioni E; Menéndez-Arias L; Alcaro S; Le Grice SF; Tramontano E
PLoS One; 2016; 11(1):e0147225. PubMed ID: 26800261
[TBL] [Abstract][Full Text] [Related]
12. Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.
Billamboz M; Bailly F; Lion C; Touati N; Vezin H; Calmels C; Andréola ML; Christ F; Debyser Z; Cotelle P
J Med Chem; 2011 Mar; 54(6):1812-24. PubMed ID: 21366258
[TBL] [Abstract][Full Text] [Related]
13. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction.
Zhang FH; Debnath B; Xu ZL; Yang LM; Song LR; Zheng YT; Neamati N; Long YQ
Eur J Med Chem; 2017 Jan; 125():1051-1063. PubMed ID: 27810592
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.
Gao P; Cheng X; Sun L; Song S; Álvarez M; Luczkowiak J; Pannecouque C; De Clercq E; Menéndez-Arias L; Zhan P; Liu X
Bioorg Med Chem; 2019 Sep; 27(17):3836-3845. PubMed ID: 31324562
[TBL] [Abstract][Full Text] [Related]
15. 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Tang J; Kirby KA; Huber AD; Casey MC; Ji J; Wilson DJ; Sarafianos SG; Wang Z
Eur J Med Chem; 2017 Mar; 128():168-179. PubMed ID: 28182989
[TBL] [Abstract][Full Text] [Related]
16. Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.
Kang D; Urhan Ç; Wei F; Frutos-Beltrán E; Sun L; Álvarez M; Feng D; Tao Y; Pannecouque C; De Clercq E; Menéndez-Arias L; Liu X; Zhan P
Eur J Med Chem; 2021 Dec; 225():113769. PubMed ID: 34403976
[TBL] [Abstract][Full Text] [Related]
17. 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
Billamboz M; Bailly F; Lion C; Calmels C; Andréola ML; Witvrouw M; Christ F; Debyser Z; De Luca L; Chimirri A; Cotelle P
Eur J Med Chem; 2011 Feb; 46(2):535-46. PubMed ID: 21185110
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.
Didierjean J; Isel C; Querré F; Mouscadet JF; Aubertin AM; Valnot JY; Piettre SR; Marquet R
Antimicrob Agents Chemother; 2005 Dec; 49(12):4884-94. PubMed ID: 16304149
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester–AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors.
Manyeruke MH; Olomola TO; Majumder S; Abrahams S; Isaacs M; Mautsa N; Mosebi S; Mnkandhla D; Hewer R; Hoppe HC; Klein R; Kaye PT
Bioorg Med Chem; 2015 Dec; 23(24):7521-8. PubMed ID: 26775541
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
Vernekar SK; Liu Z; Nagy E; Miller L; Kirby KA; Wilson DJ; Kankanala J; Sarafianos SG; Parniak MA; Wang Z
J Med Chem; 2015 Jan; 58(2):651-64. PubMed ID: 25522204
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
