These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 31816172)

  • 1. Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.
    Kalinin DV; Jana SK; Pfafenrot M; Chakrabarti A; Melesina J; Shaik TB; Lancelot J; Pierce RJ; Sippl W; Romier C; Jung M; Holl R
    ChemMedChem; 2020 Apr; 15(7):571-584. PubMed ID: 31816172
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
    Ghazy E; Heimburg T; Lancelot J; Zeyen P; Schmidtkunz K; Truhn A; Darwish S; Simoben CV; Shaik TB; Erdmann F; Schmidt M; Robaa D; Romier C; Jung M; Pierce R; Sippl W
    Eur J Med Chem; 2021 Dec; 225():113745. PubMed ID: 34392190
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.
    Stenzel K; Chakrabarti A; Melesina J; Hansen FK; Lancelot J; Herkenhöhner S; Lungerich B; Marek M; Romier C; Pierce RJ; Sippl W; Jung M; Kurz T
    Arch Pharm (Weinheim); 2017 Aug; 350(8):. PubMed ID: 28639720
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
    Stolfa DA; Marek M; Lancelot J; Hauser AT; Walter A; Leproult E; Melesina J; Rumpf T; Wurtz JM; Cavarelli J; Sippl W; Pierce RJ; Romier C; Jung M
    J Mol Biol; 2014 Oct; 426(20):3442-53. PubMed ID: 24657767
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.
    Bayer T; Chakrabarti A; Lancelot J; Shaik TB; Hausmann K; Melesina J; Schmidtkunz K; Marek M; Erdmann F; Schmidt M; Robaa D; Romier C; Pierce RJ; Jung M; Sippl W
    ChemMedChem; 2018 Aug; 13(15):1517-1529. PubMed ID: 29806110
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
    Simoben CV; Robaa D; Chakrabarti A; Schmidtkunz K; Marek M; Lancelot J; Kannan S; Melesina J; Shaik TB; Pierce RJ; Romier C; Jung M; Sippl W
    Molecules; 2018 Mar; 23(3):. PubMed ID: 29498707
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
    Marek M; Kannan S; Hauser AT; Moraes Mourão M; Caby S; Cura V; Stolfa DA; Schmidtkunz K; Lancelot J; Andrade L; Renaud JP; Oliveira G; Sippl W; Jung M; Cavarelli J; Pierce RJ; Romier C
    PLoS Pathog; 2013; 9(9):e1003645. PubMed ID: 24086136
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of
    Simoben CV; Ghazy E; Zeyen P; Darwish S; Schmidt M; Romier C; Robaa D; Sippl W
    Molecules; 2021 Apr; 26(9):. PubMed ID: 33925246
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Screening and Phenotypical Characterization of
    Saccoccia F; Brindisi M; Gimmelli R; Relitti N; Guidi A; Saraswati AP; Cavella C; Brogi S; Chemi G; Butini S; Papoff G; Senger J; Herp D; Jung M; Campiani G; Gemma S; Ruberti G
    ACS Infect Dis; 2020 Jan; 6(1):100-113. PubMed ID: 31661956
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.
    Hassan MM; Sedighi A; Olaoye OO; Häberli C; Merz A; Ramos-Morales E; de Araujo ED; Romier C; Jung M; Keiser J; Gunning PT
    ChemMedChem; 2022 Sep; 17(18):e202100622. PubMed ID: 35983937
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.
    Kannan S; Melesina J; Hauser AT; Chakrabarti A; Heimburg T; Schmidtkunz K; Walter A; Marek M; Pierce RJ; Romier C; Jung M; Sippl W
    J Chem Inf Model; 2014 Oct; 54(10):3005-19. PubMed ID: 25243797
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation.
    Aboeldahab AMA; Beshr EAM; Shoman ME; Rabea SM; Aly OM
    Eur J Med Chem; 2018 Feb; 146():79-92. PubMed ID: 29396364
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
    Saccoccia F; Pozzetti L; Gimmelli R; Butini S; Guidi A; Papoff G; Giannaccari M; Brogi S; Scognamiglio V; Gemma S; Ruberti G; Campiani G
    J Biol Chem; 2022 Oct; 298(10):102375. PubMed ID: 35970392
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
    Heimburg T; Chakrabarti A; Lancelot J; Marek M; Melesina J; Hauser AT; Shaik TB; Duclaud S; Robaa D; Erdmann F; Schmidt M; Romier C; Pierce RJ; Jung M; Sippl W
    J Med Chem; 2016 Mar; 59(6):2423-35. PubMed ID: 26937828
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.
    Suzuki T; Muto N; Bando M; Itoh Y; Masaki A; Ri M; Ota Y; Nakagawa H; Iida S; Shirahige K; Miyata N
    ChemMedChem; 2014 Mar; 9(3):657-64. PubMed ID: 24403121
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of 4-piperidin-4-yl-triazole derivatives as novel histone deacetylase inhibitors.
    Miao H; Gao J; Mou Z; Wang B; Zhang L; Su L; Han Y; Luan Y
    Biosci Trends; 2019 May; 13(2):197-203. PubMed ID: 31019142
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.
    Noce B; Di Bello E; Zwergel C; Fioravanti R; Valente S; Rotili D; Masotti A; Salik Zeya Ansari M; Trisciuoglio D; Chakrabarti A; Romier C; Robaa D; Sippl W; Jung M; Häberli C; Keiser J; Mai A
    ChemMedChem; 2023 Feb; 18(3):e202200510. PubMed ID: 36250286
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
    Marek M; Oliveira G; Pierce RJ; Jung M; Sippl W; Romier C
    Future Med Chem; 2015; 7(6):783-800. PubMed ID: 25996070
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analysis of the interactome of Schistosoma mansoni histone deacetylase 8.
    Caby S; Pagliazzo L; Lancelot J; Saliou JM; Bertheaume N; Pierce RJ; Roger E
    PLoS Negl Trop Dis; 2017 Nov; 11(11):e0006089. PubMed ID: 29155817
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.
    Cai J; Wei H; Hong KH; Wu X; Cao M; Zong X; Li L; Sun C; Chen J; Ji M
    Eur J Med Chem; 2015; 96():1-13. PubMed ID: 25874326
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.