324 related articles for article (PubMed ID: 31816384)
1. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
[TBL] [Abstract][Full Text] [Related]
2. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH
Zhang M; Jang H; Gaponenko V; Nussinov R
Biophys J; 2017 Nov; 113(9):1956-1967. PubMed ID: 29117520
[TBL] [Abstract][Full Text] [Related]
3. The structural basis for Ras activation of PI3Kα lipid kinase.
Zhang M; Jang H; Nussinov R
Phys Chem Chem Phys; 2019 Jun; 21(22):12021-12028. PubMed ID: 31135801
[TBL] [Abstract][Full Text] [Related]
4. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
[TBL] [Abstract][Full Text] [Related]
5. The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Mol Cancer Res; 2015 Sep; 13(9):1265-73. PubMed ID: 26085527
[TBL] [Abstract][Full Text] [Related]
6. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Expert Opin Ther Targets; 2016 Jul; 20(7):831-42. PubMed ID: 26873344
[TBL] [Abstract][Full Text] [Related]
7. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
[TBL] [Abstract][Full Text] [Related]
8. Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
Nussinov R; Zhang M; Tsai CJ; Jang H
Biochim Biophys Acta Mol Basis Dis; 2018 Jun; 1864(6 Pt B):2304-2314. PubMed ID: 29097261
[TBL] [Abstract][Full Text] [Related]
9. Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.
Chakrabarti M; Gabelli SB; Amzel LM
Structure; 2020 Apr; 28(4):465-474.e5. PubMed ID: 32049032
[TBL] [Abstract][Full Text] [Related]
10. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
[TBL] [Abstract][Full Text] [Related]
11. The higher level of complexity of K-Ras4B activation at the membrane.
Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
[TBL] [Abstract][Full Text] [Related]
12. Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect.
He X; Du K; Wang Y; Fan J; Li M; Ni D; Lu S; Bian X; Liu Y
Front Mol Biosci; 2022; 9():860962. PubMed ID: 35463958
[TBL] [Abstract][Full Text] [Related]
13. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
[TBL] [Abstract][Full Text] [Related]
14. Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.
Ni D; Liu D; Zhang J; Lu S
Int J Mol Sci; 2018 Jan; 19(1):. PubMed ID: 29300353
[TBL] [Abstract][Full Text] [Related]
15. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
Lu S; Jang H; Nussinov R; Zhang J
Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
[TBL] [Abstract][Full Text] [Related]
16. Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP
Buckles TC; Ziemba BP; Masson GR; Williams RL; Falke JJ
Biophys J; 2017 Dec; 113(11):2396-2405. PubMed ID: 29211993
[TBL] [Abstract][Full Text] [Related]
17. Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B to the Ordered Conformation.
Zhang H; Ni D; Fan J; Li M; Zhang J; Hua C; Nussinov R; Lu S
J Chem Inf Model; 2022 Sep; 62(17):4222-4231. PubMed ID: 35994329
[TBL] [Abstract][Full Text] [Related]
18. Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.
Martinez NG; Thieker DF; Carey LM; Rasquinha JA; Kistler SK; Kuhlman BA; Campbell SL
J Mol Biol; 2021 Apr; 433(8):166838. PubMed ID: 33539876
[TBL] [Abstract][Full Text] [Related]
19. K-Ras
Feng H; Zhang Y; Bos PH; Chambers JM; Dupont MM; Stockwell BR
Biochemistry; 2019 May; 58(21):2542-2554. PubMed ID: 31042025
[TBL] [Abstract][Full Text] [Related]
20. Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms.
Weise K; Kapoor S; Denter C; Nikolaus J; Opitz N; Koch S; Triola G; Herrmann A; Waldmann H; Winter R
J Am Chem Soc; 2011 Feb; 133(4):880-7. PubMed ID: 21141956
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]