BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 31839539)

  • 1. Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
    Jung S; Yoon NG; Yang S; Kim D; Lee WS; Hong KB; Lee C; Kang BH; Lee JH; Kang S
    Bioorg Med Chem Lett; 2020 Jan; 30(2):126809. PubMed ID: 31839539
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
    Kim D; Kim SY; Kim D; Yoon NG; Yun J; Hong KB; Lee C; Lee JH; Kang BH; Kang S
    Bioorg Chem; 2020 Aug; 101():103901. PubMed ID: 32590225
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.
    Park HK; Jeong H; Ko E; Lee G; Lee JE; Lee SK; Lee AJ; Im JY; Hu S; Kim SH; Lee JH; Lee C; Kang S; Kang BH
    J Med Chem; 2017 Sep; 60(17):7569-7578. PubMed ID: 28816449
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural aspects of triazole derivatives as HSP90 inhibitors for the treatment of cancer:
    Dhiman S; Saha M; Ali A; Ali A; Gupta GD; Asati V
    J Biomol Struct Dyn; 2023 Jul; 41(10):4756-4769. PubMed ID: 35665636
    [TBL] [Abstract][Full Text] [Related]  

  • 5. TRAP1: a viable therapeutic target for future cancer treatments?
    Lettini G; Maddalena F; Sisinni L; Condelli V; Matassa DS; Costi MP; Simoni D; Esposito F; Landriscina M
    Expert Opin Ther Targets; 2017 Aug; 21(8):805-815. PubMed ID: 28664757
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
    Merfeld T; Peng S; Keegan BM; Crowley VM; Brackett CM; Gutierrez A; McCann NR; Reynolds TS; Rhodes MC; Byrd KM; Deng J; Matts RL; Blagg BSJ
    Eur J Med Chem; 2023 Oct; 258():115531. PubMed ID: 37307624
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.
    Taddei M; Ferrini S; Giannotti L; Corsi M; Manetti F; Giannini G; Vesci L; Milazzo FM; Alloatti D; Guglielmi MB; Castorina M; Cervoni ML; Barbarino M; Foderà R; Carollo V; Pisano C; Armaroli S; Cabri W
    J Med Chem; 2014 Mar; 57(6):2258-74. PubMed ID: 24588105
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
    Patel HJ; Patel PD; Ochiana SO; Yan P; Sun W; Patel MR; Shah SK; Tramentozzi E; Brooks J; Bolaender A; Shrestha L; Stephani R; Finotti P; Leifer C; Li Z; Gewirth DT; Taldone T; Chiosis G
    J Med Chem; 2015 May; 58(9):3922-43. PubMed ID: 25901531
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and biological evaluation of 4-(1H-1,2,3-triazol-1-yl)benzamides as HSP90 inhibitors.
    He T; Zhu S; Lu W
    Mol Divers; 2023 Feb; 27(1):239-248. PubMed ID: 35429283
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.
    Lee C; Park HK; Jeong H; Lim J; Lee AJ; Cheon KY; Kim CS; Thomas AP; Bae B; Kim ND; Kim SH; Suh PG; Ryu JH; Kang BH
    J Am Chem Soc; 2015 Apr; 137(13):4358-67. PubMed ID: 25785725
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor.
    Liu S; Street TO
    Protein Sci; 2016 Dec; 25(12):2209-2215. PubMed ID: 27667530
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.
    Mishra SJ; Ghosh S; Stothert AR; Dickey CA; Blagg BS
    ACS Chem Biol; 2017 Jan; 12(1):244-253. PubMed ID: 27959508
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.
    Terracciano S; Chini MG; Piaz FD; Vassallo A; Riccio R; Bruno I; Bifulco G
    Eur J Med Chem; 2013 Jul; 65():464-76. PubMed ID: 23770448
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Drug Design, Synthesis and In Vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors.
    Kadasi S; Costa TEMM; Arukala N; Toshakani M; Duggineti C; Thota S; Dutta Gupta S; Raj S; Penido C; Henriques MG; Raghavendra NM
    Med Chem; 2018; 14(1):44-52. PubMed ID: 28641528
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
    Llauger L; He H; Kim J; Aguirre J; Rosen N; Peters U; Davies P; Chiosis G
    J Med Chem; 2005 Apr; 48(8):2892-905. PubMed ID: 15828828
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.
    Ernst JT; Liu M; Zuccola H; Neubert T; Beaumont K; Turnbull A; Kallel A; Vought B; Stamos D
    Bioorg Med Chem Lett; 2014 Jan; 24(1):204-8. PubMed ID: 24332488
    [TBL] [Abstract][Full Text] [Related]  

  • 17. NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
    Huck JD; Que NLS; Immormino RM; Shrestha L; Taldone T; Chiosis G; Gewirth DT
    J Biol Chem; 2019 Nov; 294(44):16010-16019. PubMed ID: 31501246
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
    Lee JH; Kang KW; Kim JE; Hwang SW; Park JH; Kim SH; Ji JH; Kim TG; Nam HY; Roh MS; Lee EH; Park MI; Kim MS; Lee HW
    Int J Clin Exp Pathol; 2015; 8(8):9487-93. PubMed ID: 26464709
    [TBL] [Abstract][Full Text] [Related]  

  • 19. New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.
    Rondanin R; Lettini G; Oliva P; Baruchello R; Costantini C; Trapella C; Simoni D; Bernardi T; Sisinni L; Pietrafesa M; Ponterini G; Costi MP; Vignudelli T; Luciani R; Matassa DS; Esposito F; Landriscina M
    Bioorg Med Chem Lett; 2018 Jul; 28(13):2289-2293. PubMed ID: 29807796
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
    Park HK; Yoon NG; Lee JE; Hu S; Yoon S; Kim SY; Hong JH; Nam D; Chae YC; Park JB; Kang BH
    Exp Mol Med; 2020 Jan; 52(1):79-91. PubMed ID: 31956271
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.