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9. The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models. Sigaud R; Rösch L; Gatzweiler C; Benzel J; von Soosten L; Peterziel H; Selt F; Najafi S; Ayhan S; Gerloff XF; Hofmann N; Büdenbender I; Schmitt L; Foerster KI; Burhenne J; Haefeli WE; Korshunov A; Sahm F; van Tilburg CM; Jones DTW; Pfister SM; Knoerzer D; Kreider BL; Sauter M; Pajtler KW; Zuckermann M; Oehme I; Witt O; Milde T Neuro Oncol; 2023 Mar; 25(3):566-579. PubMed ID: 35882450 [TBL] [Abstract][Full Text] [Related]
10. A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in Usta D; Sigaud R; Buhl JL; Selt F; Marquardt V; Pauck D; Jansen J; Pusch S; Ecker J; Hielscher T; Vollmer J; Sommerkamp AC; Rubner T; Hargrave D; van Tilburg CM; Pfister SM; Jones DTW; Remke M; Brummer T; Witt O; Milde T Mol Cancer Ther; 2020 Aug; 19(8):1736-1750. PubMed ID: 32451331 [TBL] [Abstract][Full Text] [Related]
11. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Grossauer S; Koeck K; Murphy NE; Meyers ID; Daynac M; Truffaux N; Truong AY; Nicolaides TP; McMahon M; Berger MS; Phillips JJ; James CD; Petritsch CK Oncotarget; 2016 Nov; 7(46):75839-75853. PubMed ID: 27713119 [TBL] [Abstract][Full Text] [Related]
12. Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma. Wei BR; Hoover SB; Peer CJ; Dwyer JE; Adissu HA; Shankarappa P; Yang H; Lee M; Peat TJ; Figg WD; Simpson RM Mol Cancer Ther; 2020 Nov; 19(11):2308-2318. PubMed ID: 32943547 [TBL] [Abstract][Full Text] [Related]
13. Early experience with targeted therapy as a first-line adjuvant treatment for pediatric low-grade glioma. Leclair NK; Lambert W; Roche K; Gillan E; Gell JJ; Lau CC; Wrubel G; Knopf J; Amin S; Anderson M; Martin JE; Bookland MJ; Hersh DS Neurosurg Focus; 2022 Dec; 53(6):E15. PubMed ID: 36455272 [TBL] [Abstract][Full Text] [Related]
14. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Olow A; Mueller S; Yang X; Hashizume R; Meyerowitz J; Weiss W; Resnick AC; Waanders AJ; Stalpers LJ; Berger MS; Gupta N; James CD; Petritsch CK; Haas-Kogan DA Clin Cancer Res; 2016 Nov; 22(21):5312-5321. PubMed ID: 27217440 [TBL] [Abstract][Full Text] [Related]
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20. HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways. Nakabayashi H; Shimizu K Cancer Sci; 2011 Feb; 102(2):393-9. PubMed ID: 21166955 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]