BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 31855604)

  • 1. Computational Design of Myristoylated Cell-Penetrating Peptides Targeting Oncogenic K-Ras.G12D at the Effector-Binding Membrane Interface.
    Li Z; Buck M
    J Chem Inf Model; 2020 Jan; 60(1):306-315. PubMed ID: 31855604
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
    Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
    Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
    Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
    J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
    Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
    J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The higher level of complexity of K-Ras4B activation at the membrane.
    Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
    FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.
    Jang H; Abraham SJ; Chavan TS; Hitchinson B; Khavrutskii L; Tarasova NI; Nussinov R; Gaponenko V
    J Biol Chem; 2015 Apr; 290(15):9465-77. PubMed ID: 25713064
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
    Lu S; Jang H; Nussinov R; Zhang J
    Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
    [TBL] [Abstract][Full Text] [Related]  

  • 8. K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.
    Cao S; Chung S; Kim S; Li Z; Manor D; Buck M
    J Biol Chem; 2019 Apr; 294(17):7068-7084. PubMed ID: 30792310
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability.
    Andreadelis I; Kiriakidi S; Lamprakis C; Theodoropoulou A; Doerr S; Chatzigoulas A; Manchester J; Velez-Vega C; Duca JS; Cournia Z
    J Phys Chem B; 2022 Feb; 126(7):1504-1519. PubMed ID: 35142524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. K-Ras
    Feng H; Zhang Y; Bos PH; Chambers JM; Dupont MM; Stockwell BR
    Biochemistry; 2019 May; 58(21):2542-2554. PubMed ID: 31042025
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dissociation of the Signaling Protein K-Ras4B from Lipid Membranes Induced by a Molecular Tweezer.
    Li L; Erwin N; Möbitz S; Niemeyer F; Schrader T; Winter RHA
    Chemistry; 2019 Jul; 25(42):9827-9833. PubMed ID: 31141233
    [TBL] [Abstract][Full Text] [Related]  

  • 12. GTP-Dependent K-Ras Dimerization.
    Muratcioglu S; Chavan TS; Freed BC; Jang H; Khavrutskii L; Freed RN; Dyba MA; Stefanisko K; Tarasov SG; Gursoy A; Keskin O; Tarasova NI; Gaponenko V; Nussinov R
    Structure; 2015 Jul; 23(7):1325-35. PubMed ID: 26051715
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Methionine 170 is an Environmentally Sensitive Membrane Anchor in the Disordered HVR of K-Ras4B.
    Neale C; García AE
    J Phys Chem B; 2018 Nov; 122(44):10086-10096. PubMed ID: 30351122
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
    Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
    J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of the Spatial Organization of Raf Isoforms Interacting with K-Ras4B in the Lipid Membrane.
    Li L; Möbitz S; Winter R
    Langmuir; 2020 Jun; 36(21):5944-5953. PubMed ID: 32390436
    [TBL] [Abstract][Full Text] [Related]  

  • 16. K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
    Sakamoto K; Kamada Y; Sameshima T; Yaguchi M; Niida A; Sasaki S; Miwa M; Ohkubo S; Sakamoto JI; Kamaura M; Cho N; Tani A
    Biochem Biophys Res Commun; 2017 Mar; 484(3):605-611. PubMed ID: 28153726
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
    Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
    Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins.
    Pincus MR
    Front Biosci; 2004 Sep; 9():3486-509. PubMed ID: 15353372
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Oncogenic G12D mutation alters local conformations and dynamics of K-Ras.
    Vatansever S; Erman B; Gümüş ZH
    Sci Rep; 2019 Aug; 9(1):11730. PubMed ID: 31409810
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization.
    Muratcioglu S; Jang H; Gursoy A; Keskin O; Nussinov R
    J Phys Chem B; 2017 Jun; 121(24):5917-5927. PubMed ID: 28540724
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.