BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 31859507)

  • 1. Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
    Lefranc J; Schulze VK; Hillig RC; Briem H; Prinz F; Mengel A; Heinrich T; Balint J; Rengachari S; Irlbacher H; Stöckigt D; Bömer U; Bader B; Gradl SN; Nising CF; von Nussbaum F; Mumberg D; Panne D; Wengner AM
    J Med Chem; 2020 Jan; 63(2):601-612. PubMed ID: 31859507
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.
    Hutti JE; Porter MA; Cheely AW; Cantley LC; Wang X; Kireev D; Baldwin AS; Janzen WP
    PLoS One; 2012; 7(7):e41494. PubMed ID: 22859992
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.
    Wang T; Block MA; Cowen S; Davies AM; Devereaux E; Gingipalli L; Johannes J; Larsen NA; Su Q; Tucker JA; Whitston D; Wu J; Zhang HJ; Zinda M; Chuaqui C
    Bioorg Med Chem Lett; 2012 Mar; 22(5):2063-9. PubMed ID: 22305584
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases.
    Johannes JW; Chuaqui C; Cowen S; Devereaux E; Gingipalli L; Molina A; Wang T; Whitston D; Wu X; Zhang HJ; Zinda M
    Bioorg Med Chem Lett; 2014 Feb; 24(4):1138-43. PubMed ID: 24462666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
    Clark K; Plater L; Peggie M; Cohen P
    J Biol Chem; 2009 May; 284(21):14136-46. PubMed ID: 19307177
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
    Beyett TS; Gan X; Reilly SM; Gomez AV; Chang L; Tesmer JJG; Saltiel AR; Showalter HD
    Bioorg Med Chem; 2018 Nov; 26(20):5443-5461. PubMed ID: 30270002
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways.
    Möller M; Wasel J; Schmetzer J; Weiß U; Meissner M; Schiffmann S; Weigert A; Möser CV; Niederberger E
    Int J Mol Sci; 2020 Jul; 21(13):. PubMed ID: 32630674
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
    McIver EG; Bryans J; Birchall K; Chugh J; Drake T; Lewis SJ; Osborne J; Smiljanic-Hurley E; Tsang W; Kamal A; Levy A; Newman M; Taylor D; Arthur JS; Clark K; Cohen P
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7169-73. PubMed ID: 23099093
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.
    Zhou Z; Qi J; Lim CW; Kim JW; Kim B
    Toxicology; 2020 Nov; 444():152579. PubMed ID: 32905826
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex.
    Huang L; Xiong T; Yu H; Zhang Q; Zhang K; Li C; Hu L; Zhang Y; Zhang L; Liu Q; Wang S; He X; Bu Z; Cai X; Cui S; Li J; Weng C
    Biochem J; 2017 Jun; 474(12):2051-2065. PubMed ID: 28487378
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
    Liang Q; Fu B; Wu F; Li X; Yuan Y; Zhu F
    J Virol; 2012 Sep; 86(18):10162-72. PubMed ID: 22787218
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.
    Harris J; Olière S; Sharma S; Sun Q; Lin R; Hiscott J; Grandvaux N
    J Immunol; 2006 Aug; 177(4):2527-35. PubMed ID: 16888014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.
    Niederberger E; Möser CV; Kynast KL; Geisslinger G
    Curr Mol Med; 2013 Aug; 13(7):1089-97. PubMed ID: 23157677
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation.
    Zhang K; Zhang Y; Xue J; Meng Q; Liu H; Bi C; Li C; Hu L; Yu H; Xiong T; Yang Y; Cui S; Bu Z; He X; Li J; Huang L; Weng C
    Cell Rep; 2019 Jan; 26(5):1258-1272.e4. PubMed ID: 30699353
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK
    Beyett TS; Gan X; Reilly SM; Chang L; Gomez AV; Saltiel AR; Showalter HD; Tesmer JJG
    Mol Pharmacol; 2018 Oct; 94(4):1210-1219. PubMed ID: 30082428
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.
    Kaukinen P; Sillanpää M; Nousiainen L; Melén K; Julkunen I
    J Med Virol; 2013 Jan; 85(1):71-82. PubMed ID: 23096996
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
    Tu D; Zhu Z; Zhou AY; Yun CH; Lee KE; Toms AV; Li Y; Dunn GP; Chan E; Thai T; Yang S; Ficarro SB; Marto JA; Jeon H; Hahn WC; Barbie DA; Eck MJ
    Cell Rep; 2013 Mar; 3(3):747-58. PubMed ID: 23453972
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation and function of IKK and IKK-related kinases.
    Häcker H; Karin M
    Sci STKE; 2006 Oct; 2006(357):re13. PubMed ID: 17047224
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
    tenOever BR; Sharma S; Zou W; Sun Q; Grandvaux N; Julkunen I; Hemmi H; Yamamoto M; Akira S; Yeh WC; Lin R; Hiscott J
    J Virol; 2004 Oct; 78(19):10636-49. PubMed ID: 15367631
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.
    Zhang H; Chen L; Cai SH; Cheng H
    Leuk Res; 2016 Jul; 46():37-44. PubMed ID: 27123832
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.