216 related articles for article (PubMed ID: 31860301)
1. Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
Rappas M; Ali AAE; Bennett KA; Brown JD; Bucknell SJ; Congreve M; Cooke RM; Cseke G; de Graaf C; Doré AS; Errey JC; Jazayeri A; Marshall FH; Mason JS; Mould R; Patel JC; Tehan BG; Weir M; Christopher JA
J Med Chem; 2020 Feb; 63(4):1528-1543. PubMed ID: 31860301
[TBL] [Abstract][Full Text] [Related]
2. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Suno R; Kimura KT; Nakane T; Yamashita K; Wang J; Fujiwara T; Yamanaka Y; Im D; Horita S; Tsujimoto H; Tawaramoto MS; Hirokawa T; Nango E; Tono K; Kameshima T; Hatsui T; Joti Y; Yabashi M; Shimamoto K; Yamamoto M; Rosenbaum DM; Iwata S; Shimamura T; Kobayashi T
Structure; 2018 Jan; 26(1):7-19.e5. PubMed ID: 29225076
[TBL] [Abstract][Full Text] [Related]
3. Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Yin J; Babaoglu K; Brautigam CA; Clark L; Shao Z; Scheuermann TH; Harrell CM; Gotter AL; Roecker AJ; Winrow CJ; Renger JJ; Coleman PJ; Rosenbaum DM
Nat Struct Mol Biol; 2016 Apr; 23(4):293-9. PubMed ID: 26950369
[TBL] [Abstract][Full Text] [Related]
4. Determinants of Orexin Receptor Binding and Activation-A Molecular Dynamics Study.
Karhu L; Magarkar A; Bunker A; Xhaard H
J Phys Chem B; 2019 Mar; 123(12):2609-2622. PubMed ID: 30786708
[TBL] [Abstract][Full Text] [Related]
5. Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor.
Gunera J; Baker JG; van Hilten N; Rosenbaum DM; Kolb P
J Med Chem; 2020 Oct; 63(19):11045-11053. PubMed ID: 32977721
[TBL] [Abstract][Full Text] [Related]
6. In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist.
Beuckmann CT; Suzuki M; Ueno T; Nagaoka K; Arai T; Higashiyama H
J Pharmacol Exp Ther; 2017 Aug; 362(2):287-295. PubMed ID: 28559480
[TBL] [Abstract][Full Text] [Related]
7. Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Hellmann J; Drabek M; Yin J; Gunera J; Pröll T; Kraus F; Langmead CJ; Hübner H; Weikert D; Kolb P; Rosenbaum DM; Gmeiner P
Proc Natl Acad Sci U S A; 2020 Jul; 117(30):18059-18067. PubMed ID: 32669442
[TBL] [Abstract][Full Text] [Related]
8. Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands.
Turku A; Borrel A; Leino TO; Karhu L; Kukkonen JP; Xhaard H
J Med Chem; 2016 Sep; 59(18):8263-75. PubMed ID: 27546834
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Yin J; Mobarec JC; Kolb P; Rosenbaum DM
Nature; 2015 Mar; 519(7542):247-50. PubMed ID: 25533960
[TBL] [Abstract][Full Text] [Related]
10. Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders.
Bonifazi A; Del Bello F; Giorgioni G; Piergentili A; Saab E; Botticelli L; Cifani C; Micioni Di Bonaventura E; Micioni Di Bonaventura MV; Quaglia W
Med Res Rev; 2023 Sep; 43(5):1607-1667. PubMed ID: 37036052
[TBL] [Abstract][Full Text] [Related]
11. Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM-878.
Maehara S; Yuge N; Higashi C; Ota T; Furukawa J; Takeuchi T
Neuropsychopharmacol Rep; 2020 Jun; 40(2):182-189. PubMed ID: 32337858
[TBL] [Abstract][Full Text] [Related]
12. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.
Mould R; Brown J; Marshall FH; Langmead CJ
Br J Pharmacol; 2014 Jan; 171(2):351-63. PubMed ID: 23692283
[TBL] [Abstract][Full Text] [Related]
13. Orexin research: patent news from 2016.
Boss C; Roch C
Expert Opin Ther Pat; 2017 Oct; 27(10):1123-1133. PubMed ID: 28631980
[TBL] [Abstract][Full Text] [Related]
14. Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis.
Heifetz A; Morris GB; Biggin PC; Barker O; Fryatt T; Bentley J; Hallett D; Manikowski D; Pal S; Reifegerste R; Slack M; Law R
Biochemistry; 2012 Apr; 51(15):3178-97. PubMed ID: 22448975
[TBL] [Abstract][Full Text] [Related]
15. Modeling of the OX1R-orexin-A complex suggests two alternative binding modes.
Karhu L; Turku A; Xhaard H
BMC Struct Biol; 2015 May; 15():9. PubMed ID: 25957175
[TBL] [Abstract][Full Text] [Related]
16. Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor.
Perrey DA; German NA; Decker AM; Thorn D; Li JX; Gilmour BP; Thomas BF; Harris DL; Runyon SP; Zhang Y
ACS Chem Neurosci; 2015 Apr; 6(4):599-614. PubMed ID: 25643283
[TBL] [Abstract][Full Text] [Related]
17. Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Hong C; Byrne NJ; Zamlynny B; Tummala S; Xiao L; Shipman JM; Partridge AT; Minnick C; Breslin MJ; Rudd MT; Stachel SJ; Rada VL; Kern JC; Armacost KA; Hollingsworth SA; O'Brien JA; Hall DL; McDonald TP; Strickland C; Brooun A; Soisson SM; Hollenstein K
Nat Commun; 2021 Feb; 12(1):815. PubMed ID: 33547286
[TBL] [Abstract][Full Text] [Related]
18. Investigation of New Orexin 2 Receptor Modulators Using
Janockova J; Dolezal R; Nepovimova E; Kobrlova T; Benkova M; Kuca K; Konecny J; Mezeiova E; Melikova M; Hepnarova V; Ring A; Soukup O; Korabecny J
Molecules; 2018 Nov; 23(11):. PubMed ID: 30423961
[TBL] [Abstract][Full Text] [Related]
19. Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis.
Heifetz A; Barker O; Morris GB; Law RJ; Slack M; Biggin PC
Biochemistry; 2013 Nov; 52(46):8246-60. PubMed ID: 24144388
[TBL] [Abstract][Full Text] [Related]
20. The Human Orexin/Hypocretin Receptor Crystal Structures.
Yin J; Rosenbaum DM
Curr Top Behav Neurosci; 2017; 33():1-15. PubMed ID: 28025809
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
