These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
6. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context? Plashkevych O; Li Q; Chattopadhyaya J Mol Biosyst; 2017 May; 13(5):921-938. PubMed ID: 28352859 [TBL] [Abstract][Full Text] [Related]
7. Synthesis of scpBNA- Horiba M; Yamaguchi T; Obika S J Org Chem; 2016 Nov; 81(22):11000-11008. PubMed ID: 27779877 [TBL] [Abstract][Full Text] [Related]
9. Down-regulation of VEGF mRNA expression by 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) antisense oligonucleotides and investigation of non-target gene expression. Morita K; Yamate K; Kurakata S; Abe K; Imanishi T; Koizumi M Nucleic Acids Res Suppl; 2002; (2):99-100. PubMed ID: 12903124 [TBL] [Abstract][Full Text] [Related]
10. Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides. Kasuya T; Hori S; Watanabe A; Nakajima M; Gahara Y; Rokushima M; Yanagimoto T; Kugimiya A Sci Rep; 2016 Jul; 6():30377. PubMed ID: 27461380 [TBL] [Abstract][Full Text] [Related]
11. Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids. Lima WF; Crooke ST Biochemistry; 1997 Jan; 36(2):390-8. PubMed ID: 9003192 [TBL] [Abstract][Full Text] [Related]
12. Synthesis and properties of 2'-O,4'-C-spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2',4'-BNA/LNA bearing a cyclopropane ring. Yamaguchi T; Horiba M; Obika S Chem Commun (Camb); 2015 Jun; 51(47):9737-40. PubMed ID: 25985928 [TBL] [Abstract][Full Text] [Related]
13. Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides. Lok CN; Viazovkina E; Min KL; Nagy E; Wilds CJ; Damha MJ; Parniak MA Biochemistry; 2002 Mar; 41(10):3457-67. PubMed ID: 11876654 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring. Shrestha AR; Hari Y; Yahara A; Osawa T; Obika S J Org Chem; 2011 Dec; 76(24):9891-9. PubMed ID: 22059648 [TBL] [Abstract][Full Text] [Related]
15. Is irrelevant cleavage the price of antisense efficacy? Stein CA Pharmacol Ther; 2000 Mar; 85(3):231-6. PubMed ID: 10739877 [TBL] [Abstract][Full Text] [Related]
16. Synthesis of 4'-C-(aminoethyl)thymidine and 4'-C-[(N-methyl)aminoethyl]thymidine by a new synthetic route and evaluation of the properties of the DNAs containing the nucleoside analogs. Ueda H; Ueno Y Bioorg Med Chem; 2022 Apr; 60():116690. PubMed ID: 35259549 [TBL] [Abstract][Full Text] [Related]
17. Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties. Zhou C; Liu Y; Andaloussi M; Badgujar N; Plashkevych O; Chattopadhyaya J J Org Chem; 2009 Jan; 74(1):118-34. PubMed ID: 19055352 [TBL] [Abstract][Full Text] [Related]
18. Synthesis and duplex-forming ability of oligonucleotides modified with 4'-C,5'-C-methylene-bridged nucleic acid (4',5'-BNA). Yamaguchi T; Yamamoto C; Horiba M; Aoyama H; Obika S Bioorg Med Chem; 2021 Sep; 46():116359. PubMed ID: 34391942 [TBL] [Abstract][Full Text] [Related]
19. (S)-5'-C-Aminopropyl-2'-O-methyl nucleosides enhance antisense activity in cultured cells and binding affinity to complementary single-stranded RNA. Kajino R; Ueno Y Bioorg Med Chem; 2021 Jan; 30():115925. PubMed ID: 33310631 [TBL] [Abstract][Full Text] [Related]
20. Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties. Ogata A; Maeda Y; Ueno Y Bioorg Med Chem; 2017 Apr; 25(7):2035-2042. PubMed ID: 28242172 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]