BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 31869450)

  • 1. The emerging role of mediator complex subunit 12 in tumorigenesis and response to chemotherapeutics.
    Zhang S; O'Regan R; Xu W
    Cancer; 2020 Mar; 126(5):939-948. PubMed ID: 31869450
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseases.
    Srivastava S; Kulshreshtha R
    J Cell Physiol; 2021 May; 236(5):3163-3177. PubMed ID: 33174211
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
    Kämpjärvi K; Kim NH; Keskitalo S; Clark AD; von Nandelstadh P; Turunen M; Heikkinen T; Park MJ; Mäkinen N; Kivinummi K; Lintula S; Hotakainen K; Nevanlinna H; Hokland P; Böhling T; Bützow R; Böhm J; Mecklin JP; Järvinen H; Kontro M; Visakorpi T; Taipale J; Varjosalo M; Boyer TG; Vahteristo P
    Prostate; 2016 Jan; 76(1):22-31. PubMed ID: 26383637
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
    Huang S; Hölzel M; Knijnenburg T; Schlicker A; Roepman P; McDermott U; Garnett M; Grernrum W; Sun C; Prahallad A; Groenendijk FH; Mittempergher L; Nijkamp W; Neefjes J; Salazar R; Ten Dijke P; Uramoto H; Tanaka F; Beijersbergen RL; Wessels LF; Bernards R
    Cell; 2012 Nov; 151(5):937-50. PubMed ID: 23178117
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
    Mäkinen N; Mehine M; Tolvanen J; Kaasinen E; Li Y; Lehtonen HJ; Gentile M; Yan J; Enge M; Taipale M; Aavikko M; Katainen R; Virolainen E; Böhling T; Koski TA; Launonen V; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA
    Science; 2011 Oct; 334(6053):252-5. PubMed ID: 21868628
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
    Kämpjärvi K; Park MJ; Mehine M; Kim NH; Clark AD; Bützow R; Böhling T; Böhm J; Mecklin JP; Järvinen H; Tomlinson IP; van der Spuy ZM; Sjöberg J; Boyer TG; Vahteristo P
    Hum Mutat; 2014 Sep; 35(9):1136-41. PubMed ID: 24980722
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.
    Han Y; Dong Q; Liu T; Chen X; Yu C; Zhang Y
    Biochem Biophys Res Commun; 2022 Jun; 610():1-7. PubMed ID: 35461070
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MED12 mutations in human diseases.
    Wang H; Shen Q; Ye LH; Ye J
    Protein Cell; 2013 Sep; 4(9):643-6. PubMed ID: 23836153
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
    Turunen M; Spaeth JM; Keskitalo S; Park MJ; Kivioja T; Clark AD; Mäkinen N; Gao F; Palin K; Nurkkala H; Vähärautio A; Aavikko M; Kämpjärvi K; Vahteristo P; Kim CA; Aaltonen LA; Varjosalo M; Taipale J; Boyer TG
    Cell Rep; 2014 May; 7(3):654-60. PubMed ID: 24746821
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC.
    Xu M; Wang F; Li G; Wang X; Fang X; Jin H; Chen Z; Zhang J; Fu L
    Mol Cancer; 2019 May; 18(1):93. PubMed ID: 31072327
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR.
    Luo XL; Deng CC; Su XD; Wang F; Chen Z; Wu XP; Liang SB; Liu JH; Fu LW
    Cancer Res; 2018 Jul; 78(13):3532-3543. PubMed ID: 29735544
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mediator kinase module and human tumorigenesis.
    Clark AD; Oldenbroek M; Boyer TG
    Crit Rev Biochem Mol Biol; 2015; 50(5):393-426. PubMed ID: 26182352
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NEAT1 repression by MED12 creates chemosensitivity in p53 wild-type breast cancer cells.
    Zhang S; Kim EJ; Huang J; Liu P; Donahue K; Wang Q; Wang Y; Mcilwain S; Xie L; Chen X; Li L; Xu W
    FEBS J; 2024 May; 291(9):1909-1924. PubMed ID: 38380720
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MED12 somatic mutations encompassing exon 2 associated with benign breast fibroadenomas and not breast carcinoma in Indian women.
    Darooei M; Khan F; Rehan M; Zubeda S; Jeyashanker E; Annapurna S; Shah A; Maddali S; Hasan Q
    J Cell Biochem; 2019 Jan; 120(1):182-191. PubMed ID: 30230586
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.
    Voutsadakis IA
    Pharmacol Rep; 2024 Jun; 76(3):535-556. PubMed ID: 38602606
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
    Klatt F; Leitner A; Kim IV; Ho-Xuan H; Schneider EV; Langhammer F; Weinmann R; Müller MR; Huber R; Meister G; Kuhn CD
    Proc Natl Acad Sci U S A; 2020 Feb; 117(6):2894-2905. PubMed ID: 31988137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis.
    Srivastava S; Makala H; Sharma V; Suri V; Sarkar C; Kulshreshtha R
    Cell Mol Life Sci; 2022 Jan; 79(2):104. PubMed ID: 35091793
    [TBL] [Abstract][Full Text] [Related]  

  • 19. RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.
    Ishikawa H; Kobayashi T; Kaneko M; Saito Y; Shozu M; Koga K
    J Mol Endocrinol; 2023 Nov; 71(4):. PubMed ID: 37668348
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
    Kim NH; Livi CB; Yew PR; Boyer TG
    BMC Dev Biol; 2016 May; 16(1):17. PubMed ID: 27188461
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.