371 related articles for article (PubMed ID: 31870439)
1. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
[TBL] [Abstract][Full Text] [Related]
2. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Arrant AE; Onyilo VC; Unger DE; Roberson ED
J Neurosci; 2018 Feb; 38(9):2341-2358. PubMed ID: 29378861
[TBL] [Abstract][Full Text] [Related]
3. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
[TBL] [Abstract][Full Text] [Related]
4. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
Arrant AE; Filiano AJ; Patel AR; Hoffmann MQ; Boyle NR; Kashyap SN; Onyilo VC; Young AH; Roberson ED
Neurobiol Dis; 2019 Apr; 124():152-162. PubMed ID: 30448285
[TBL] [Abstract][Full Text] [Related]
5. Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
Arrant AE; Nicholson AM; Zhou X; Rademakers R; Roberson ED
Mol Neurodegener; 2018 Jun; 13(1):32. PubMed ID: 29929528
[TBL] [Abstract][Full Text] [Related]
6. Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity.
Valdez C; Ysselstein D; Young TJ; Zheng J; Krainc D
Hum Mol Genet; 2020 Mar; 29(5):716-726. PubMed ID: 31600775
[TBL] [Abstract][Full Text] [Related]
7. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
Filiano AJ; Martens LH; Young AH; Warmus BA; Zhou P; Diaz-Ramirez G; Jiao J; Zhang Z; Huang EJ; Gao FB; Farese RV; Roberson ED
J Neurosci; 2013 Mar; 33(12):5352-61. PubMed ID: 23516300
[TBL] [Abstract][Full Text] [Related]
8. Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
Davis SE; Cook AK; Hall JA; Voskobiynyk Y; Carullo NV; Boyle NR; Hakim AR; Anderson KM; Hobdy KP; Pugh DA; Murchison CF; McMeekin LJ; Simmons M; Margolies KA; Cowell RM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Arrant AE
Acta Neuropathol Commun; 2023 Apr; 11(1):70. PubMed ID: 37118844
[TBL] [Abstract][Full Text] [Related]
9. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Ward ME; Chen R; Huang HY; Ludwig C; Telpoukhovskaia M; Taubes A; Boudin H; Minami SS; Reichert M; Albrecht P; Gelfand JM; Cruz-Herranz A; Cordano C; Alavi MV; Leslie S; Seeley WW; Miller BL; Bigio E; Mesulam MM; Bogyo MS; Mackenzie IR; Staropoli JF; Cotman SL; Huang EJ; Gan L; Green AJ
Sci Transl Med; 2017 Apr; 9(385):. PubMed ID: 28404863
[TBL] [Abstract][Full Text] [Related]
10. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by
Holler CJ; Taylor G; Deng Q; Kukar T
eNeuro; 2017; 4(4):. PubMed ID: 28828399
[TBL] [Abstract][Full Text] [Related]
11. Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.
Arrant AE; Filiano AJ; Unger DE; Young AH; Roberson ED
Brain; 2017 May; 140(5):1447-1465. PubMed ID: 28379303
[TBL] [Abstract][Full Text] [Related]
12. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T
Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800
[TBL] [Abstract][Full Text] [Related]
13. Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.
Arrant AE; Davis SE; Vollmer RM; Murchison CF; Mobley JA; Nana AL; Spina S; Grinberg LT; Karydas AM; Miller BL; Seeley WW; Roberson ED
Ann Clin Transl Neurol; 2020 Dec; 7(12):2433-2449. PubMed ID: 33197149
[TBL] [Abstract][Full Text] [Related]
14. Progranulin deficiency leads to reduced glucocerebrosidase activity.
Zhou X; Paushter DH; Pagan MD; Kim D; Nunez Santos M; Lieberman RL; Overkleeft HS; Sun Y; Smolka MB; Hu F
PLoS One; 2019; 14(7):e0212382. PubMed ID: 31291241
[TBL] [Abstract][Full Text] [Related]
15. Plasma lysosphingolipids in GRN-related diseases: Monitoring lysosomal dysfunction to track disease progression.
Khrouf W; Saracino D; Rucheton B; Houot M; Clot F; Rinaldi D; Vitor J; Huynh M; Heng E; Schlemmer D; Pasquier F; Deramecourt V; Auriacombe S; Azuar C; Levy R; Bombois S; Boutoleau-Brétonnière C; Pariente J; Didic M; Wallon D; Fluchère F; Auvin S; Younes IB; ; ; Nadjar Y; Brice A; Dubois B; Bonnefont-Rousselot D; Le Ber I; Lamari F
Neurobiol Dis; 2023 Jun; 181():106108. PubMed ID: 37003407
[TBL] [Abstract][Full Text] [Related]
16. Homozygous GRN mutations: new phenotypes and new insights into pathological and molecular mechanisms.
Huin V; Barbier M; Bottani A; Lobrinus JA; Clot F; Lamari F; Chat L; Rucheton B; Fluchère F; Auvin S; Myers P; Gelot A; Camuzat A; Caillaud C; Jornéa L; Forlani S; Saracino D; Duyckaerts C; Brice A; Durr A; Le Ber I
Brain; 2020 Jan; 143(1):303-319. PubMed ID: 31855245
[TBL] [Abstract][Full Text] [Related]
17. Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.
Kashyap SN; Boyle NR; Roberson ED
Neurotherapeutics; 2023 Jan; 20(1):140-153. PubMed ID: 36781744
[TBL] [Abstract][Full Text] [Related]
18. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice.
Frew J; Nygaard HB
Acta Neuropathol Commun; 2021 Apr; 9(1):57. PubMed ID: 33795008
[TBL] [Abstract][Full Text] [Related]
19. Progranulin as a therapeutic target for dementia.
Galimberti D; Fenoglio C; Scarpini E
Expert Opin Ther Targets; 2018 Jul; 22(7):579-585. PubMed ID: 29889573
[TBL] [Abstract][Full Text] [Related]
20. AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.
Amado DA; Rieders JM; Diatta F; Hernandez-Con P; Singer A; Mak JT; Zhang J; Lancaster E; Davidson BL; Chen-Plotkin AS
Mol Ther; 2019 Feb; 27(2):465-478. PubMed ID: 30559071
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]