BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

364 related articles for article (PubMed ID: 31871053)

  • 1. Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa
    Neff RA; Flinspach M; Gibbs A; Shih AY; Minassian NA; Liu Y; Fellows R; Libiger O; Young S; Pennington MW; Hunter MJ; Wickenden AD
    J Biol Chem; 2020 Jan; 295(5):1315-1327. PubMed ID: 31871053
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
    Cardoso FC; Dekan Z; Rosengren KJ; Erickson A; Vetter I; Deuis JR; Herzig V; Alewood PF; King GF; Lewis RJ
    Mol Pharmacol; 2015 Aug; 88(2):291-303. PubMed ID: 25979003
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
    Chow CY; Cristofori-Armstrong B; Undheim EA; King GF; Rash LD
    Toxins (Basel); 2015 Jun; 7(7):2494-513. PubMed ID: 26134258
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of the Spider (
    Gonçalves TC; Lesport P; Kuylle S; Stura E; Ciolek J; Mourier G; Servent D; Bourinet E; Benoit E; Gilles N
    Toxins (Basel); 2019 Aug; 11(9):. PubMed ID: 31443554
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na
    Rupasinghe DB; Herzig V; Vetter I; Dekan Z; Gilchrist J; Bosmans F; Alewood PF; Lewis RJ; King GF
    Biochem Pharmacol; 2020 Nov; 181():114080. PubMed ID: 32511987
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.
    Revell JD; Lund PE; Linley JE; Metcalfe J; Burmeister N; Sridharan S; Jones C; Jermutus L; Bednarek MA
    Peptides; 2013 Jun; 44():40-6. PubMed ID: 23523779
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
    Rahnama S; Deuis JR; Cardoso FC; Ramanujam V; Lewis RJ; Rash LD; King GF; Vetter I; Mobli M
    PLoS One; 2017; 12(3):e0173551. PubMed ID: 28301520
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Engineering of highly potent and selective HNTX-III mutant against hNa
    Zhang Y; Wang L; Peng D; Zhang Q; Yang Q; Li J; Li D; Tang D; Chen M; Liang S; Liu Y; Wang S; Liu Z
    J Biol Chem; 2021; 296():100326. PubMed ID: 33493520
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
    Moyer BD; Murray JK; Ligutti J; Andrews K; Favreau P; Jordan JB; Lee JH; Liu D; Long J; Sham K; Shi L; Stöcklin R; Wu B; Yin R; Yu V; Zou A; Biswas K; Miranda LP
    PLoS One; 2018; 13(5):e0196791. PubMed ID: 29723257
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
    Minassian NA; Gibbs A; Shih AY; Liu Y; Neff RA; Sutton SW; Mirzadegan T; Connor J; Fellows R; Husovsky M; Nelson S; Hunter MJ; Flinspach M; Wickenden AD
    J Biol Chem; 2013 Aug; 288(31):22707-20. PubMed ID: 23760503
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.
    Cardoso FC; Dekan Z; Smith JJ; Deuis JR; Vetter I; Herzig V; Alewood PF; King GF; Lewis RJ
    Br J Pharmacol; 2017 Aug; 174(15):2528-2544. PubMed ID: 28542706
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.
    Shcherbatko A; Rossi A; Foletti D; Zhu G; Bogin O; Galindo Casas M; Rickert M; Hasa-Moreno A; Bartsevich V; Crameri A; Steiner AR; Henningsen R; Gill A; Pons J; Shelton DL; Rajpal A; Strop P
    J Biol Chem; 2016 Jul; 291(27):13974-13986. PubMed ID: 27129258
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
    Cai T; Luo J; Meng E; Ding J; Liang S; Wang S; Liu Z
    Peptides; 2015 Jun; 68():148-56. PubMed ID: 25218973
    [TBL] [Abstract][Full Text] [Related]  

  • 14. µ-TRTX-Ca1a: a novel neurotoxin from Cyriopagopus albostriatus with analgesic effects.
    Zhang YX; Peng DZ; Zhang QF; Huang B; Yang QC; Tang DF; Chen MZ; Rong MQ; Liu ZH
    Acta Pharmacol Sin; 2019 Jul; 40(7):859-866. PubMed ID: 30382183
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chemical Synthesis, Proper Folding, Na
    Nicolas S; Zoukimian C; Bosmans F; Montnach J; Diochot S; Cuypers E; De Waard S; Béroud R; Mebs D; Craik D; Boturyn D; Lazdunski M; Tytgat J; De Waard M
    Toxins (Basel); 2019 Jun; 11(6):. PubMed ID: 31234412
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.
    Liu Z; Cai T; Zhu Q; Deng M; Li J; Zhou X; Zhang F; Li D; Li J; Liu Y; Hu W; Liang S
    J Biol Chem; 2013 Jul; 288(28):20392-403. PubMed ID: 23703613
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Direct evidence for high affinity blockade of Na
    Gonçalves TC; Boukaiba R; Molgó J; Amar M; Partiseti M; Servent D; Benoit E
    Neuropharmacology; 2018 May; 133():404-414. PubMed ID: 29474819
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na
    Katz D; Sindhikara D; DiMattia M; Leffler AE
    Toxins (Basel); 2021 Mar; 13(3):. PubMed ID: 33800031
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
    Agwa AJ; Tran P; Mueller A; Tran HNT; Deuis JR; Israel MR; McMahon KL; Craik DJ; Vetter I; Schroeder CI
    J Biol Chem; 2020 Apr; 295(15):5067-5080. PubMed ID: 32139508
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.
    Peschel A; Cardoso FC; Walker AA; Durek T; Stone MRL; Braga Emidio N; Dawson PE; Muttenthaler M; King GF
    J Med Chem; 2020 Nov; 63(21):12773-12785. PubMed ID: 33078946
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.