233 related articles for article (PubMed ID: 31875479)
1. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
Xu D; Dai W; Kutzler L; Lacko HA; Jefferson LS; Dennis MD; Kimball SR
J Nutr; 2020 May; 150(5):1022-1030. PubMed ID: 31875479
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Jang SK; Hong SE; Lee DH; Kim JY; Kim JY; Ye SK; Hong J; Park IC; Jin HO
BMC Cancer; 2021 Jul; 21(1):803. PubMed ID: 34253170
[TBL] [Abstract][Full Text] [Related]
3. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
Dennis MD; McGhee NK; Jefferson LS; Kimball SR
Cell Signal; 2013 Dec; 25(12):2709-16. PubMed ID: 24018049
[TBL] [Abstract][Full Text] [Related]
4. Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes.
Sawa R; Ohnishi A; Ohno M; Nagata M; Wake I; Okimura Y
Biochim Biophys Acta Gen Subj; 2022 Sep; 1866(9):130174. PubMed ID: 35597502
[TBL] [Abstract][Full Text] [Related]
5. Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.
Gordon BS; Williamson DL; Lang CH; Jefferson LS; Kimball SR
J Nutr; 2015 Apr; 145(4):708-13. PubMed ID: 25716553
[TBL] [Abstract][Full Text] [Related]
6. The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.
Sawa R; Wake I; Yamamoto Y; Okimura Y
Growth Horm IGF Res; 2021 Aug; 59():101406. PubMed ID: 34126555
[TBL] [Abstract][Full Text] [Related]
7. Resistance exercise enhances long-term mTORC1 sensitivity to leucine.
D'Hulst G; Masschelein E; De Bock K
Mol Metab; 2022 Dec; 66():101615. PubMed ID: 36252815
[TBL] [Abstract][Full Text] [Related]
8. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Torrence ME; MacArthur MR; Hosios AM; Valvezan AJ; Asara JM; Mitchell JR; Manning BD
Elife; 2021 Mar; 10():. PubMed ID: 33646118
[TBL] [Abstract][Full Text] [Related]
9. Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis.
Jin HO; Hong SE; Kim JY; Jang SK; Park IC
Cell Death Dis; 2021 Dec; 12(12):1127. PubMed ID: 34862383
[TBL] [Abstract][Full Text] [Related]
10. Regulation of Gene Expression by Amino Acids in Animal Cells.
Sah N; Wu G; Bazer FW
Adv Exp Med Biol; 2021; 1332():1-15. PubMed ID: 34251635
[TBL] [Abstract][Full Text] [Related]
11. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
Averous J; Lambert-Langlais S; Mesclon F; Carraro V; Parry L; Jousse C; Bruhat A; Maurin AC; Pierre P; Proud CG; Fafournoux P
Sci Rep; 2016 Jun; 6():27698. PubMed ID: 27297692
[TBL] [Abstract][Full Text] [Related]
12. Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.
Griffiths A; Wang J; Song Q; Iyamu ID; Liu L; Park J; Jiang Y; Huang R; Song Z
Am J Physiol Cell Physiol; 2021 Sep; 321(3):C585-C595. PubMed ID: 34378991
[TBL] [Abstract][Full Text] [Related]
13. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
[TBL] [Abstract][Full Text] [Related]
14. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Condon KJ; Orozco JM; Adelmann CH; Spinelli JB; van der Helm PW; Roberts JM; Kunchok T; Sabatini DM
Proc Natl Acad Sci U S A; 2021 Jan; 118(4):. PubMed ID: 33483422
[TBL] [Abstract][Full Text] [Related]
15. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Ye J; Palm W; Peng M; King B; Lindsten T; Li MO; Koumenis C; Thompson CB
Genes Dev; 2015 Nov; 29(22):2331-6. PubMed ID: 26543160
[TBL] [Abstract][Full Text] [Related]
16. Glucose promotes cell growth and casein synthesis via ATF4/Nrf2-Sestrin2- AMPK-mTORC1 pathway in dairy cow mammary epithelial cells.
Yu W; Guo J; Mao L; Wang Q; Liu Y; Xu D; Ma J; Luo C
Anim Biotechnol; 2023 Dec; 34(8):3808-3818. PubMed ID: 37435839
[TBL] [Abstract][Full Text] [Related]
17. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Byles V; Cormerais Y; Kalafut K; Barrera V; Hughes Hallett JE; Sui SH; Asara JM; Adams CM; Hoxhaj G; Ben-Sahra I; Manning BD
Mol Metab; 2021 Nov; 53():101309. PubMed ID: 34303878
[TBL] [Abstract][Full Text] [Related]
18. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Kimball SR; Gordon BS; Moyer JE; Dennis MD; Jefferson LS
Cell Signal; 2016 Aug; 28(8):896-906. PubMed ID: 27010498
[TBL] [Abstract][Full Text] [Related]
19. Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.
McGhee NK; Jefferson LS; Kimball SR
J Nutr; 2009 May; 139(5):828-34. PubMed ID: 19297425
[TBL] [Abstract][Full Text] [Related]
20. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
Whitney ML; Jefferson LS; Kimball SR
Biochem Biophys Res Commun; 2009 Feb; 379(2):451-5. PubMed ID: 19114033
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]