217 related articles for article (PubMed ID: 31881455)
1. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.
Sun N; Ma X; Zhou K; Zhu C; Cao Z; Wang Y; Xu J; Fu W
Eur J Med Chem; 2020 Feb; 187():111984. PubMed ID: 31881455
[TBL] [Abstract][Full Text] [Related]
2. Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists.
Xia Y; Yu M; Zhao Y; Xia L; Huang Y; Sun N; Song M; Guo H; Zhang Y; Zhu D; Xie Q; Wang Y
Eur J Med Chem; 2021 Feb; 211():113013. PubMed ID: 33272782
[TBL] [Abstract][Full Text] [Related]
3. Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists.
Ma X; Sun N; Li X; Fu W
Eur J Med Chem; 2021 Oct; 222():113585. PubMed ID: 34118722
[TBL] [Abstract][Full Text] [Related]
4. Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor γt inverse agonists.
Chen L; Su M; Wu XZ; Wang DZ; Kang YY; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Jin Q; Huang RZ; Liao ZX
Eur J Med Chem; 2022 Feb; 229():114065. PubMed ID: 34971876
[TBL] [Abstract][Full Text] [Related]
5. Discovery of N-indanyl benzamides as potent RORγt inverse agonists.
Tian J; Sun N; Yu M; Gu X; Xie Q; Shao L; Liu J; Liu L; Wang Y
Eur J Med Chem; 2019 Apr; 167():37-48. PubMed ID: 30743096
[TBL] [Abstract][Full Text] [Related]
6. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists.
Wang Y; Yang T; Liu Q; Ma Y; Yang L; Zhou L; Xiang Z; Cheng Z; Lu S; Orband-Miller LA; Zhang W; Wu Q; Zhang K; Li Y; Xiang JN; Elliott JD; Leung S; Ren F; Lin X
Bioorg Med Chem; 2015 Sep; 23(17):5293-302. PubMed ID: 26277758
[TBL] [Abstract][Full Text] [Related]
7. Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
Chen L; Su M; Jin Q; Wang W; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
J Med Chem; 2021 Nov; 64(21):16106-16131. PubMed ID: 34723528
[TBL] [Abstract][Full Text] [Related]
8. 6-Substituted quinolines as RORγt inverse agonists.
Barbay JK; Cummings MD; Abad M; Castro G; Kreutter KD; Kummer DA; Maharoof U; Milligan C; Nishimura R; Pierce J; Schalk-Hihi C; Spurlino J; Tanis VM; Urbanski M; Venkatesan H; Wang A; Woods C; Wolin R; Xue X; Edwards JP; Fourie AM; Leonard K
Bioorg Med Chem Lett; 2017 Dec; 27(23):5277-5283. PubMed ID: 29079472
[TBL] [Abstract][Full Text] [Related]
9. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.
Lu L; Chen S; Yu M; Zhou R; Guo S; Chen JA; Wang H; Chen S; Luo C; Xie Q; Wang Y
Eur J Med Chem; 2023 Aug; 256():115424. PubMed ID: 37167779
[TBL] [Abstract][Full Text] [Related]
10. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.
Meijer FA; Doveston RG; de Vries RMJM; Vos GM; Vos AAA; Leysen S; Scheepstra M; Ottmann C; Milroy LG; Brunsveld L
J Med Chem; 2020 Jan; 63(1):241-259. PubMed ID: 31821760
[TBL] [Abstract][Full Text] [Related]
11. Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile.
Nakajima R; Oono H; Kumazawa K; Ida T; Hirata J; White RD; Min X; Guzman-Perez A; Wang Z; Symons A; Singh SK; Mothe SR; Belyakov S; Chakrabarti A; Shuto S
Bioorg Med Chem Lett; 2021 Mar; 36():127786. PubMed ID: 33493627
[TBL] [Abstract][Full Text] [Related]
12. Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis.
Ouvry G; Atrux-Tallau N; Bihl F; Bondu A; Bouix-Peter C; Carlavan I; Christin O; Cuadrado MJ; Defoin-Platel C; Deret S; Duvert D; Feret C; Forissier M; Fournier JF; Froude D; Hacini-Rachinel F; Harris CS; Hervouet C; Huguet H; Lafitte G; Luzy AP; Musicki B; Orfila D; Ozello B; Pascau C; Pascau J; Parnet V; Peluchon G; Pierre R; Piwnica D; Raffin C; Rossio P; Spiesse D; Taquet N; Thoreau E; Vatinel R; Vial E; Hennequin LF
ChemMedChem; 2018 Feb; 13(4):321-337. PubMed ID: 29327456
[TBL] [Abstract][Full Text] [Related]
13. Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.
Kummer DA; Cummings MD; Abad M; Barbay J; Castro G; Wolin R; Kreutter KD; Maharoof U; Milligan C; Nishimura R; Pierce J; Schalk-Hihi C; Spurlino J; Urbanski M; Venkatesan H; Wang A; Woods C; Xue X; Edwards JP; Fourie AM; Leonard K
Bioorg Med Chem Lett; 2017 May; 27(9):2047-2057. PubMed ID: 28318945
[TBL] [Abstract][Full Text] [Related]
14. Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α.
Doebelin C; He Y; Campbell S; Nuhant P; Kumar N; Koenig M; Garcia-Ordonez R; Chang MR; Roush WR; Lin L; Kahn S; Cameron MD; Griffin PR; Solt LA; Kamenecka TM
Med Chem; 2019; 15(6):676-684. PubMed ID: 30799793
[TBL] [Abstract][Full Text] [Related]
15. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
Chen L; Su M; Jin Q; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
Bioorg Chem; 2022 Feb; 119():105483. PubMed ID: 34906860
[TBL] [Abstract][Full Text] [Related]
16. Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
Yukawa T; Nara Y; Kono M; Sato A; Oda T; Takagi T; Sato T; Banno Y; Taya N; Imada T; Shiokawa Z; Negoro N; Kawamoto T; Koyama R; Uchiyama N; Skene R; Hoffman I; Chen CH; Sang B; Snell G; Katsuyama R; Yamamoto S; Shirai J
J Med Chem; 2019 Feb; 62(3):1167-1179. PubMed ID: 30652849
[TBL] [Abstract][Full Text] [Related]
17. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
[TBL] [Abstract][Full Text] [Related]
18. Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
Fauber BP; René O; Deng Y; DeVoss J; Eidenschenk C; Everett C; Ganguli A; Gobbi A; Hawkins J; Johnson AR; La H; Lesch J; Lockey P; Norman M; Ouyang W; Summerhill S; Wong H
J Med Chem; 2015 Jul; 58(13):5308-22. PubMed ID: 26061388
[TBL] [Abstract][Full Text] [Related]
19. Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.
Koyama R; Fukuda Y; Kamada Y; Nakagawa H; Witmer D; Ambrus-Aikelin G; Sang BC; Nakayama M; Iwata H
Assay Drug Dev Technol; 2018; 16(4):194-204. PubMed ID: 29874096
[TBL] [Abstract][Full Text] [Related]
20. Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
Kono M; Ochida A; Oda T; Imada T; Banno Y; Taya N; Masada S; Kawamoto T; Yonemori K; Nara Y; Fukase Y; Yukawa T; Tokuhara H; Skene R; Sang BC; Hoffman ID; Snell GP; Uga K; Shibata A; Igaki K; Nakamura Y; Nakagawa H; Tsuchimori N; Yamasaki M; Shirai J; Yamamoto S
J Med Chem; 2018 Apr; 61(7):2973-2988. PubMed ID: 29510038
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
