118 related articles for article (PubMed ID: 31902903)
1. Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK).
Kuramoto K; Sawada Y; Ishibashi N; Yamada T; Nagashima T; Shin T
Chem Pharm Bull (Tokyo); 2020; 68(1):77-90. PubMed ID: 31902903
[TBL] [Abstract][Full Text] [Related]
2. Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.
Kuramoto K; Yamada H; Shin T; Sawada Y; Azami H; Yamada T; Nagashima T; Ohnuki K
Bioorg Med Chem; 2020 Mar; 28(5):115307. PubMed ID: 32007387
[TBL] [Abstract][Full Text] [Related]
3. Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.
Kuramoto K; Sawada Y; Yamada T; Nagashima T; Ohnuki K; Shin T
Chem Pharm Bull (Tokyo); 2020; 68(5):452-465. PubMed ID: 32378543
[TBL] [Abstract][Full Text] [Related]
4. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
Babkov DA; Zhukowskaya ON; Borisov AV; Babkova VA; Sokolova EV; Brigadirova AA; Litvinov RA; Kolodina AA; Morkovnik AS; Sochnev VS; Borodkin GS; Spasov AA
Bioorg Med Chem Lett; 2019 Sep; 29(17):2443-2447. PubMed ID: 31358465
[TBL] [Abstract][Full Text] [Related]
5. Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators.
Dokla EM; Fang CS; Lai PT; Kulp SK; Serya RA; Ismail NS; Abouzid KA; Chen CS
ChemMedChem; 2015 Nov; 10(11):1915-23. PubMed ID: 26350292
[TBL] [Abstract][Full Text] [Related]
6. Role of AMP-activated protein kinase activators in antiproliferative multi-drug pituitary tumour therapies: effects of combined treatments with compounds affecting the mTOR-p70S6 kinase axis in cultured pituitary tumour cells.
Tulipano G; Faggi L; Cacciamali A; Spinello M; Cocchi D; Giustina A
J Neuroendocrinol; 2015 Jan; 27(1):20-32. PubMed ID: 25323047
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKɑ1β1γ1 activators.
Xiao Z; Peng Y; Zheng B; Chang Q; Guo Y; Chen Z; Li Q; Hu G
Arch Pharm (Weinheim); 2021 Jul; 354(7):e2000458. PubMed ID: 33683726
[TBL] [Abstract][Full Text] [Related]
8. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.
Lan P; Romero FA; Wodka D; Kassick AJ; Dang Q; Gibson T; Cashion D; Zhou G; Chen Y; Zhang X; Zhang A; Li Y; Trujillo ME; Shao Q; Wu M; Xu S; He H; MacKenna D; Staunton J; Chapman KT; Weber A; Sebhat IK; Makara GM
J Med Chem; 2017 Nov; 60(21):9040-9052. PubMed ID: 29035567
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.
Wang J; Liu J; Xie Z; Li J; Li J; Hu L
Bioorg Med Chem Lett; 2020 Jan; 30(2):126790. PubMed ID: 31744674
[TBL] [Abstract][Full Text] [Related]
10. Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Velaparthi U; Saulnier MG; Wittman MD; Liu P; Frennesson DB; Zimmermann K; Carboni JM; Gottardis M; Li A; Greer A; Clarke W; Yang Z; Menard K; Lee FY; Trainor G; Vyas D
Bioorg Med Chem Lett; 2010 May; 20(10):3182-5. PubMed ID: 20399649
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationships of pyrazolo-[3,4-b]pyridine derivatives as adenosine 5'-monophosphate-activated protein kinase activators.
Zheng B; Peng Y; Wu W; Ma J; Zhang Y; Guo Y; Sun S; Chen Z; Li Q; Hu G
Arch Pharm (Weinheim); 2019 Aug; 352(8):e1900066. PubMed ID: 31373047
[TBL] [Abstract][Full Text] [Related]
12. Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.
Velaparthi U; Wittman M; Liu P; Carboni JM; Lee FY; Attar R; Balimane P; Clarke W; Sinz MW; Hurlburt W; Patel K; Discenza L; Kim S; Gottardis M; Greer A; Li A; Saulnier M; Yang Z; Zimmermann K; Trainor G; Vyas D
J Med Chem; 2008 Oct; 51(19):5897-900. PubMed ID: 18763755
[TBL] [Abstract][Full Text] [Related]
13. Fluorinated N,N'-diarylureas as AMPK activators.
Sviripa V; Zhang W; Conroy MD; Schmidt ES; Liu AX; Truong J; Liu C; Watt DS
Bioorg Med Chem Lett; 2013 Mar; 23(6):1600-3. PubMed ID: 23414799
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5'-monophosphate-activated protein kinase (AMPK).
Gu Z; Wu L; Duan Y; Wang J; Zhou S; Li J; Chen K; Li J; Liu H
Bioorg Med Chem; 2018 May; 26(8):2017-2027. PubMed ID: 29545016
[TBL] [Abstract][Full Text] [Related]
15. Microwave-assisted synthesis of 2(1H)-pyridones and their glucosides as cell proliferation inhibitors.
Al-Neyadi SS; Hassan AH; Abdou IM
Nucleosides Nucleotides Nucleic Acids; 2011 Feb; 30(2):120-34. PubMed ID: 21360410
[TBL] [Abstract][Full Text] [Related]
16. Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.
Zhang M; Xie ZF; Zhang RT; Chen DK; Gu M; Cui SC; Zhang YM; Zhang XW; Yu YY; Li J; Nan FJ; Li JY
Acta Pharmacol Sin; 2018 Oct; 39(10):1622-1632. PubMed ID: 29795358
[TBL] [Abstract][Full Text] [Related]
17. Computer-aided drug design for AMP-activated protein kinase activators.
Wang Z; Huo J; Sun L; Wang Y; Jin H; Yu H; Zhang L; Zhou L
Curr Comput Aided Drug Des; 2011 Sep; 7(3):214-27. PubMed ID: 21595631
[TBL] [Abstract][Full Text] [Related]
18. Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.
Zhang D; Ai J; Liang Z; Zhu W; Peng X; Chen X; Ji Y; Jiang H; Luo C; Geng M; Liu H
Bioorg Med Chem Lett; 2013 Apr; 23(8):2408-13. PubMed ID: 23474386
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives.
Chand K; Prasad S; Tiwari RK; Shirazi AN; Kumar S; Parang K; Sharma SK
Bioorg Chem; 2014 Apr; 53():75-82. PubMed ID: 24632506
[TBL] [Abstract][Full Text] [Related]
20. A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth.
Plews RL; Mohd Yusof A; Wang C; Saji M; Zhang X; Chen CS; Ringel MD; Phay JE
J Clin Endocrinol Metab; 2015 May; 100(5):E748-56. PubMed ID: 25710562
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]