141 related articles for article (PubMed ID: 31904416)
1. Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells.
Krishan S; Sahni S; Leck LYW; Jansson PJ; Richardson DR
Biochim Biophys Acta Mol Basis Dis; 2020 May; 1866(5):165657. PubMed ID: 31904416
[TBL] [Abstract][Full Text] [Related]
2. NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization.
Sahni S; Gillson J; Park KC; Chiang S; Leck LYW; Jansson PJ; Richardson DR
Biochim Biophys Acta Gen Subj; 2020 Aug; 1864(8):129625. PubMed ID: 32335136
[TBL] [Abstract][Full Text] [Related]
3. The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.
Krishan S; Richardson DR; Sahni S
Biochim Biophys Acta; 2016 Dec; 1863(12):2916-2933. PubMed ID: 27639899
[TBL] [Abstract][Full Text] [Related]
4. Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJ; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR
Biochim Biophys Acta; 2016 Jul; 1863(7 Pt A):1665-81. PubMed ID: 27102538
[TBL] [Abstract][Full Text] [Related]
5. The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis.
Krishan S; Sahni S; Richardson DR
Biochim Biophys Acta Mol Basis Dis; 2020 Dec; 1866(12):165970. PubMed ID: 32950675
[TBL] [Abstract][Full Text] [Related]
6. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
Gutierrez E; Richardson DR; Jansson PJ
J Biol Chem; 2014 Nov; 289(48):33568-89. PubMed ID: 25301941
[TBL] [Abstract][Full Text] [Related]
7. Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
Jansson PJ; Yamagishi T; Arvind A; Seebacher N; Gutierrez E; Stacy A; Maleki S; Sharp D; Sahni S; Richardson DR
J Biol Chem; 2015 Apr; 290(15):9588-603. PubMed ID: 25720491
[TBL] [Abstract][Full Text] [Related]
8. A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.
Seebacher NA; Richardson DR; Jansson PJ
Cell Death Dis; 2016 Dec; 7(12):e2510. PubMed ID: 27906178
[TBL] [Abstract][Full Text] [Related]
9. Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding.
Park KC; Geleta B; Leck LYW; Paluncic J; Chiang S; Jansson PJ; Kovacevic Z; Richardson DR
J Biol Chem; 2020 Jan; 295(2):481-503. PubMed ID: 31744884
[TBL] [Abstract][Full Text] [Related]
10. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR
Biochem Pharmacol; 2016 Jun; 109():27-47. PubMed ID: 27059255
[TBL] [Abstract][Full Text] [Related]
11. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy.
Wang ST; Huang SW; Kao JK; Liang SM; Chen YJ; Chen YY; Wu CY; Shieh JJ
J Dermatol Sci; 2015 May; 78(2):108-16. PubMed ID: 25766763
[TBL] [Abstract][Full Text] [Related]
12. Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21
Moussa RS; Kovacevic Z; Bae DH; Lane DJR; Richardson DR
Biochim Biophys Acta Gen Subj; 2018 Mar; 1862(3):761-774. PubMed ID: 29032246
[TBL] [Abstract][Full Text] [Related]
13. Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.
Al-Akra L; Bae DH; Sahni S; Huang MLH; Park KC; Lane DJR; Jansson PJ; Richardson DR
J Biol Chem; 2018 Mar; 293(10):3562-3587. PubMed ID: 29305422
[TBL] [Abstract][Full Text] [Related]
14. PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Chen ZT; Zhao W; Qu S; Li L; Lu XD; Su F; Liang ZG; Guo SY; Zhu XD
Mol Med Rep; 2015 Aug; 12(2):1868-76. PubMed ID: 25872765
[TBL] [Abstract][Full Text] [Related]
15. Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Min H; Xu M; Chen ZR; Zhou JD; Huang M; Zheng K; Zou XP
Cancer Chemother Pharmacol; 2014 Jul; 74(1):167-76. PubMed ID: 24842158
[TBL] [Abstract][Full Text] [Related]
16. Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Fernandez-Mosquera L; Yambire KF; Couto R; Pereyra L; Pabis K; Ponsford AH; Diogo CV; Stagi M; Milosevic I; Raimundo N
Autophagy; 2019 Sep; 15(9):1572-1591. PubMed ID: 30917721
[TBL] [Abstract][Full Text] [Related]
17. The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.
Sahni S; Bae DH; Lane DJ; Kovacevic Z; Kalinowski DS; Jansson PJ; Richardson DR
J Biol Chem; 2014 Apr; 289(14):9692-709. PubMed ID: 24532803
[TBL] [Abstract][Full Text] [Related]
18. AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells.
Harhaji-Trajkovic L; Vilimanovich U; Kravic-Stevovic T; Bumbasirevic V; Trajkovic V
J Cell Mol Med; 2009 Sep; 13(9B):3644-54. PubMed ID: 20196784
[TBL] [Abstract][Full Text] [Related]
19. ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis.
Chung SJ; Nagaraju GP; Nagalingam A; Muniraj N; Kuppusamy P; Walker A; Woo J; Győrffy B; Gabrielson E; Saxena NK; Sharma D
Autophagy; 2017 Aug; 13(8):1386-1403. PubMed ID: 28696138
[TBL] [Abstract][Full Text] [Related]
20. Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway.
Varshney R; Gupta S; Roy P
Mol Cell Endocrinol; 2017 Jun; 448():1-20. PubMed ID: 28237721
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]