BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 31904416)

  • 1. Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells.
    Krishan S; Sahni S; Leck LYW; Jansson PJ; Richardson DR
    Biochim Biophys Acta Mol Basis Dis; 2020 May; 1866(5):165657. PubMed ID: 31904416
    [TBL] [Abstract][Full Text] [Related]  

  • 2. NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization.
    Sahni S; Gillson J; Park KC; Chiang S; Leck LYW; Jansson PJ; Richardson DR
    Biochim Biophys Acta Gen Subj; 2020 Aug; 1864(8):129625. PubMed ID: 32335136
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.
    Krishan S; Richardson DR; Sahni S
    Biochim Biophys Acta; 2016 Dec; 1863(12):2916-2933. PubMed ID: 27639899
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
    Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJ; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR
    Biochim Biophys Acta; 2016 Jul; 1863(7 Pt A):1665-81. PubMed ID: 27102538
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis.
    Krishan S; Sahni S; Richardson DR
    Biochim Biophys Acta Mol Basis Dis; 2020 Dec; 1866(12):165970. PubMed ID: 32950675
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Gutierrez E; Richardson DR; Jansson PJ
    J Biol Chem; 2014 Nov; 289(48):33568-89. PubMed ID: 25301941
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
    Jansson PJ; Yamagishi T; Arvind A; Seebacher N; Gutierrez E; Stacy A; Maleki S; Sharp D; Sahni S; Richardson DR
    J Biol Chem; 2015 Apr; 290(15):9588-603. PubMed ID: 25720491
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.
    Seebacher NA; Richardson DR; Jansson PJ
    Cell Death Dis; 2016 Dec; 7(12):e2510. PubMed ID: 27906178
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding.
    Park KC; Geleta B; Leck LYW; Paluncic J; Chiang S; Jansson PJ; Kovacevic Z; Richardson DR
    J Biol Chem; 2020 Jan; 295(2):481-503. PubMed ID: 31744884
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
    Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR
    Biochem Pharmacol; 2016 Jun; 109():27-47. PubMed ID: 27059255
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy.
    Wang ST; Huang SW; Kao JK; Liang SM; Chen YJ; Chen YY; Wu CY; Shieh JJ
    J Dermatol Sci; 2015 May; 78(2):108-16. PubMed ID: 25766763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21
    Moussa RS; Kovacevic Z; Bae DH; Lane DJR; Richardson DR
    Biochim Biophys Acta Gen Subj; 2018 Mar; 1862(3):761-774. PubMed ID: 29032246
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.
    Al-Akra L; Bae DH; Sahni S; Huang MLH; Park KC; Lane DJR; Jansson PJ; Richardson DR
    J Biol Chem; 2018 Mar; 293(10):3562-3587. PubMed ID: 29305422
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
    Chen ZT; Zhao W; Qu S; Li L; Lu XD; Su F; Liang ZG; Guo SY; Zhu XD
    Mol Med Rep; 2015 Aug; 12(2):1868-76. PubMed ID: 25872765
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
    Min H; Xu M; Chen ZR; Zhou JD; Huang M; Zheng K; Zou XP
    Cancer Chemother Pharmacol; 2014 Jul; 74(1):167-76. PubMed ID: 24842158
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
    Fernandez-Mosquera L; Yambire KF; Couto R; Pereyra L; Pabis K; Ponsford AH; Diogo CV; Stagi M; Milosevic I; Raimundo N
    Autophagy; 2019 Sep; 15(9):1572-1591. PubMed ID: 30917721
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.
    Sahni S; Bae DH; Lane DJ; Kovacevic Z; Kalinowski DS; Jansson PJ; Richardson DR
    J Biol Chem; 2014 Apr; 289(14):9692-709. PubMed ID: 24532803
    [TBL] [Abstract][Full Text] [Related]  

  • 18. AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells.
    Harhaji-Trajkovic L; Vilimanovich U; Kravic-Stevovic T; Bumbasirevic V; Trajkovic V
    J Cell Mol Med; 2009 Sep; 13(9B):3644-54. PubMed ID: 20196784
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis.
    Chung SJ; Nagaraju GP; Nagalingam A; Muniraj N; Kuppusamy P; Walker A; Woo J; Győrffy B; Gabrielson E; Saxena NK; Sharma D
    Autophagy; 2017 Aug; 13(8):1386-1403. PubMed ID: 28696138
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway.
    Varshney R; Gupta S; Roy P
    Mol Cell Endocrinol; 2017 Jun; 448():1-20. PubMed ID: 28237721
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.