BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 3190731)

  • 1. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    Jenner TJ; Sapora O; O'Neill P; Fielden EM
    Biochem Pharmacol; 1988 Oct; 37(20):3837-42. PubMed ID: 3190731
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The repair of DNA damage induced in V79 mammalian cells by the nitroimidazole-aziridine, RSU-1069. Implications for radiosensitization.
    Jenner TJ; O'Neill P; Crump PW; Fielden EM; Sapora O; Santodonato L
    Biochem Pharmacol; 1991 Oct; 42(9):1705-10. PubMed ID: 1930296
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
    Sapora O; Paone A; Maggi A; Jenner TJ; O'Neill P
    Biochem Pharmacol; 1992 Oct; 44(7):1341-7. PubMed ID: 1417957
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    O'Neill P; McNeil SS; Jenkins TC
    Biochem Pharmacol; 1987 Jun; 36(11):1787-92. PubMed ID: 3579973
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Assessment of the repair and damage of DNA induced by parent and reduced RSU-1069, a 2-nitroimidazole-aziridine.
    O'Neill P; Cunniffe SM
    Int J Radiat Oncol Biol Phys; 1989 Apr; 16(4):963-6. PubMed ID: 2649467
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A comparison of the techniques of alkaline filter elution and alkaline sucrose sedimentation used to assess DNA damage induced by 2-nitroimidazoles.
    Crump PW; Fielden EM; Jenner TJ; O'Neill P
    Biochem Pharmacol; 1990 Aug; 40(3):621-7. PubMed ID: 2383289
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparative DNA damage and repair induced by misonidazole, CB 1954 and RSU 1069.
    Dale LD; Widdick DA; Edwards DI; Biol GI
    Int J Radiat Oncol Biol Phys; 1989 Apr; 16(4):995-9. PubMed ID: 2649469
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Variation of the radiosensitizing efficiency of RSU-1069 with pre-irradiation contact times: a rapid mix study.
    Austen KR; Jenner TJ; O'Neill P; Fielden EM
    Int J Radiat Biol Relat Stud Phys Chem Med; 1987 Aug; 52(2):281-8. PubMed ID: 3497125
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytotoxicity of RSU 1069 in spheroids and murine tumors.
    Olive PL; Durand RE; Chaplin DJ
    Int J Radiat Oncol Biol Phys; 1987 Sep; 13(9):1361-6. PubMed ID: 3624045
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action.
    Stratford IJ; Walling JM; Silver AR
    Br J Cancer; 1986 Mar; 53(3):339-44. PubMed ID: 3754453
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin.
    Roizin-Towle L; Pirro JP; Hall EJ
    Radiat Res; 1990 Oct; 124(1 Suppl):S50-5. PubMed ID: 2236511
    [TBL] [Abstract][Full Text] [Related]  

  • 12. RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo.
    Adams GE; Ahmed I; Sheldon PW; Stratford IJ
    Int J Radiat Oncol Biol Phys; 1984 Sep; 10(9):1653-6. PubMed ID: 6548211
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Induction of DNA strand breaks by reduced nitroimidazoles. Implications for DNA base damage.
    Silver AR; McNeil SS; O'Neill P; Jenkins TC; Ahmed I
    Biochem Pharmacol; 1986 Nov; 35(22):3923-8. PubMed ID: 3778516
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Studies on the toxicity of RSU-1069.
    Whitmore GF; Gulyas S
    Int J Radiat Oncol Biol Phys; 1986 Jul; 12(7):1219-22. PubMed ID: 3755716
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.
    Silver AR; O'Neill P; Jenkins TC
    Biochem Pharmacol; 1985 Oct; 34(19):3537-42. PubMed ID: 3902026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage.
    O'Neill P; Jenkins TC; Stratford IJ; Silver AR; Ahmed I; McNeil SS; Fielden EM; Adams GE
    Anticancer Drug Des; 1987 Apr; 1(4):271-80. PubMed ID: 3450299
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The phosphate-group of DNA as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer.
    Silver AR; O'Neill P; Jenkins TC; McNeil SS
    Int J Radiat Oncol Biol Phys; 1986 Jul; 12(7):1203-6. PubMed ID: 3755715
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation.
    Keohane A; Godden J; Stratford IJ; Adams GE
    Br J Cancer; 1990 May; 61(5):722-6. PubMed ID: 2110815
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparative DNA damage induced by nitroimidazole-aziridine drugs: 1. Effects of methyl substitution on drug action.
    Dale LD; Tocher JH; Edwards DI
    Anticancer Drug Des; 1988 Dec; 3(3):169-75. PubMed ID: 3207464
    [TBL] [Abstract][Full Text] [Related]  

  • 20. RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.
    Stratford IJ; O'Neill P; Sheldon PW; Silver AR; Walling JM; Adams GE
    Biochem Pharmacol; 1986 Jan; 35(1):105-9. PubMed ID: 3753579
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 7.