These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

144 related articles for article (PubMed ID: 31923631)

  • 1. 4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
    Jagtap AD; Kondekar NB; Hung PY; Hsieh CE; Yang CR; Chen GS; Chern JW
    Bioorg Chem; 2020 Jan; 95():103135. PubMed ID: 31923631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
    Baxter EW; Conway KA; Kennis L; Bischoff F; Mercken MH; Winter HL; Reynolds CH; Tounge BA; Luo C; Scott MK; Huang Y; Braeken M; Pieters SM; Berthelot DJ; Masure S; Bruinzeel WD; Jordan AD; Parker MH; Boyd RE; Qu J; Alexander RS; Brenneman DE; Reitz AB
    J Med Chem; 2007 Sep; 50(18):4261-4. PubMed ID: 17685503
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.
    Yan G; Hao L; Niu Y; Huang W; Wang W; Xu F; Liang L; Wang C; Jin H; Xu P
    Eur J Med Chem; 2017 Sep; 137():462-475. PubMed ID: 28624701
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.
    Huang Y; Strobel ED; Ho CY; Reynolds CH; Conway KA; Piesvaux JA; Brenneman DE; Yohrling GJ; Moore Arnold H; Rosenthal D; Alexander RS; Tounge BA; Mercken M; Vandermeeren M; Parker MH; Reitz AB; Baxter EW
    Bioorg Med Chem Lett; 2010 May; 20(10):3158-60. PubMed ID: 20399652
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.
    Veenstra SJ; Rueeger H; Voegtle M; Lueoend R; Holzer P; Hurth K; Tintelnot-Blomley M; Frederiksen M; Rondeau JM; Jacobson L; Staufenbiel M; Neumann U; Machauer R
    Bioorg Med Chem Lett; 2018 Jul; 28(12):2195-2200. PubMed ID: 29764741
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors.
    Razzaghi-Asl N; Firuzi O; Hemmateenejad B; Javidnia K; Edraki N; Miri R
    Bioorg Med Chem; 2013 Nov; 21(22):6893-909. PubMed ID: 24113238
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation.
    Low JD; Bartberger MD; Cheng Y; Whittington D; Xue Q; Wood S; Allen JR; Minatti AE
    Bioorg Med Chem Lett; 2018 Apr; 28(6):1111-1115. PubMed ID: 29426770
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
    Choi SJ; Cho JH; Im I; Lee SD; Jang JY; Oh YM; Jung YK; Jeon ES; Kim YC
    Eur J Med Chem; 2010 Jun; 45(6):2578-90. PubMed ID: 20303626
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
    Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies.
    John S; Thangapandian S; Sakkiah S; Lee KW
    BMC Bioinformatics; 2011 Feb; 12 Suppl 1(Suppl 1):S28. PubMed ID: 21342558
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors.
    Peschiulli A; Oehlrich D; Rombouts F; Vos A; Gijsen HJ
    Bioorg Med Chem Lett; 2020 Apr; 30(8):126999. PubMed ID: 32089426
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors.
    Di Pietro O; Juárez-Jiménez J; Muñoz-Torrero D; Laughton CA; Luque FJ
    PLoS One; 2017; 12(5):e0177683. PubMed ID: 28505196
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and in vitro evaluation studies of sulfonyl-amino-acetamides as small molecule BACE-1 inhibitors.
    Jain P; Wadhwa PK; Gunapati S; Jadhav HR
    Bioorg Med Chem; 2016 Jun; 24(11):2567-2575. PubMed ID: 27102162
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors.
    Jain P; Wadhwa PK; Rohilla S; Jadhav HR
    Bioorg Med Chem Lett; 2016 Jan; 26(1):33-7. PubMed ID: 26614409
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
    Zhao XJ; Gong DM; Jiang YR; Guo D; Zhu Y; Deng YC
    Eur J Med Chem; 2017 Sep; 138():738-747. PubMed ID: 28728106
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 2D QSAR studies on series of human beta-secretase (BACE-1) inhibitors.
    Cruz DS; Castilho MS
    Med Chem; 2014 Mar; 10(2):162-73. PubMed ID: 23627297
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
    Hanessian S; Shao Z; Betschart C; Rondeau JM; Neumann U; Tintelnot-Blomley M
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1924-7. PubMed ID: 20172717
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of Alzheimer's BACE-1 with 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure.
    Miri R; Firuzi O; Razzaghi-Asl N; Javidnia K; Edraki N
    Arch Pharm Res; 2015 Apr; 38(4):456-69. PubMed ID: 24771353
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
    Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
    J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies.
    Liu P; Niu Y; Wang C; Sun Q; Zhai Y; Yu J; Sun J; Xu F; Yan G; Huang W; Liang L; Xu P
    Eur J Med Chem; 2014 May; 79():413-21. PubMed ID: 24763262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.