BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 31974452)

  • 1. Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.
    Zhu J; Singh M; Selivanova G; Peuget S
    Sci Rep; 2020 Jan; 10(1):1049. PubMed ID: 31974452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
    Lee SY; Shin SJ; Kim HS
    Int J Oncol; 2013 Mar; 42(3):1027-35. PubMed ID: 23314357
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
    Saha MN; Jiang H; Chang H
    Cancer Biol Ther; 2010 Sep; 10(6):567-78. PubMed ID: 20595817
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.
    Singh PK; Kumar R; Sharma A; Arora R; Jain SK; Sharma RK
    Biotechnol Appl Biochem; 2009 Jul; 54(1):53-64. PubMed ID: 19409072
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
    Vaseva AV; Marchenko ND; Moll UM
    Cell Cycle; 2009 Jun; 8(11):1711-9. PubMed ID: 19411846
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.
    Walton MI; Wilson SC; Hardcastle IR; Mirza AR; Workman P
    Mol Cancer Ther; 2005 Sep; 4(9):1369-77. PubMed ID: 16170029
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53.
    Choe YJ; Lee SY; Ko KW; Shin SJ; Kim HS
    Int J Oncol; 2014 Mar; 44(3):761-8. PubMed ID: 24366007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.
    Fan S; Qi M; Yu Y; Li L; Yao G; Tashiro S; Onodera S; Ikejima T
    Free Radic Res; 2012 Mar; 46(3):310-9. PubMed ID: 22283740
    [TBL] [Abstract][Full Text] [Related]  

  • 9. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.
    Kitagawa M; Aonuma M; Lee SH; Fukutake S; McCormick F
    Oncogene; 2008 Sep; 27(40):5303-14. PubMed ID: 18521084
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway.
    Mendjargal A; Odkhuu E; Koide N; Nagata H; Kurokawa T; Nonami T; Yokochi T
    Int Immunopharmacol; 2013 Apr; 15(4):671-8. PubMed ID: 23454130
    [TBL] [Abstract][Full Text] [Related]  

  • 11. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
    Zeng L; Zhang F; Zhang Z; Xu M; Xu Y; Liu Y; Xu H; Sun X; Sang M; Luo H
    J Biochem Mol Toxicol; 2021 Aug; 35(8):e22822. PubMed ID: 34091999
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
    Hasegawa H; Yamada Y; Iha H; Tsukasaki K; Nagai K; Atogami S; Sugahara K; Tsuruda K; Ishizaki A; Kamihira S
    Leukemia; 2009 Nov; 23(11):2090-101. PubMed ID: 19710698
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
    Liang L; Zhang Z
    Cell Physiol Biochem; 2016; 38(4):1618-30. PubMed ID: 27119348
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
    Yang LY; Greig NH; Huang YN; Hsieh TH; Tweedie D; Yu QS; Hoffer BJ; Luo Y; Kao YC; Wang JY
    Neurobiol Dis; 2016 Dec; 96():216-226. PubMed ID: 27553877
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.
    Yang LY; Chu YH; Tweedie D; Yu QS; Pick CG; Hoffer BJ; Greig NH; Wang JY
    Exp Neurol; 2015 Jul; 269():56-66. PubMed ID: 25819102
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.
    Hoagland MS; Hoagland EM; Swanson HI
    J Pharmacol Exp Ther; 2005 Aug; 314(2):603-10. PubMed ID: 15843497
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.
    Farah IO; Begum RA; Ishaque AB
    Biomed Sci Instrum; 2007; 43():116-21. PubMed ID: 17487067
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells.
    Wang B; Fang L; Zhao H; Xiang T; Wang D
    Acta Biochim Biophys Sin (Shanghai); 2012 Aug; 44(8):685-91. PubMed ID: 22843172
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.
    Wan C; Ma X; Shi S; Zhao J; Nie X; Han J; Xiao J; Wang X; Jiang S; Jiang J
    Toxicol Appl Pharmacol; 2014 Dec; 281(3):294-302. PubMed ID: 25448048
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
    Kanno S; Kurauchi K; Tomizawa A; Yomogida S; Ishikawa M
    Toxicol Lett; 2015 Jan; 232(2):393-402. PubMed ID: 25448278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.