517 related articles for article (PubMed ID: 31978378)
1. Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease.
Zuccarello E; Acquarone E; Calcagno E; Argyrousi EK; Deng SX; Landry DW; Arancio O; Fiorito J
Biochem Pharmacol; 2020 Jun; 176():113818. PubMed ID: 31978378
[TBL] [Abstract][Full Text] [Related]
2. Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer's disease.
Liu L; Xu H; Ding S; Wang D; Song G; Huang X
Brain Res Bull; 2019 Nov; 153():223-231. PubMed ID: 31493542
[TBL] [Abstract][Full Text] [Related]
3. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions.
Kang BW; Kim F; Cho JY; Kim S; Rhee J; Choung JJ
Alzheimers Res Ther; 2022 Jul; 14(1):92. PubMed ID: 35804462
[TBL] [Abstract][Full Text] [Related]
4. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.
Mao F; Wang H; Ni W; Zheng X; Wang M; Bao K; Ling D; Li X; Xu Y; Zhang H; Li J
ACS Chem Neurosci; 2018 Feb; 9(2):328-345. PubMed ID: 29068218
[TBL] [Abstract][Full Text] [Related]
5. Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling.
Jin F; Gong QH; Xu YS; Wang LN; Jin H; Li F; Li LS; Ma YM; Shi JS
Int J Neuropsychopharmacol; 2014 Jun; 17(6):871-81. PubMed ID: 24513083
[TBL] [Abstract][Full Text] [Related]
6. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
Puzzo D; Staniszewski A; Deng SX; Privitera L; Leznik E; Liu S; Zhang H; Feng Y; Palmeri A; Landry DW; Arancio O
J Neurosci; 2009 Jun; 29(25):8075-86. PubMed ID: 19553447
[TBL] [Abstract][Full Text] [Related]
7. The phosphodiesterase 5 inhibitor, KJH-1002, reverses a mouse model of amnesia by activating a cGMP/cAMP response element binding protein pathway and decreasing oxidative damage.
Zhang L; Seo JH; Li H; Nam G; Yang HO
Br J Pharmacol; 2018 Aug; 175(16):3347-3360. PubMed ID: 29847860
[TBL] [Abstract][Full Text] [Related]
8. Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors.
Ahmed WS; Geethakumari AM; Biswas KH
Biomed Pharmacother; 2021 Feb; 134():111128. PubMed ID: 33348311
[TBL] [Abstract][Full Text] [Related]
9. Nebivolol potentiates the efficacy of PDE5 inhibitors to relax corpus cavernosum and penile arteries from diabetic patients by enhancing the NO/cGMP pathway.
Martínez-Salamanca JI; La Fuente JM; Cardoso J; Fernández A; Cuevas P; Wright HM; Angulo J
J Sex Med; 2014 May; 11(5):1182-92. PubMed ID: 24877179
[TBL] [Abstract][Full Text] [Related]
10. Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Kelly MP
Cell Signal; 2018 Jan; 42():281-291. PubMed ID: 29175000
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Fiorito J; Saeed F; Zhang H; Staniszewski A; Feng Y; Francis YI; Rao S; Thakkar DM; Deng SX; Landry DW; Arancio O
Eur J Med Chem; 2013 Feb; 60():285-94. PubMed ID: 23313637
[TBL] [Abstract][Full Text] [Related]
12. The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders.
Degjoni A; Campolo F; Stefanini L; Venneri MA
J Thromb Haemost; 2022 Nov; 20(11):2465-2474. PubMed ID: 35950928
[TBL] [Abstract][Full Text] [Related]
13. Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice.
Zhang J; Guo J; Zhao X; Chen Z; Wang G; Liu A; Wang Q; Zhou W; Xu Y; Wang C
Behav Brain Res; 2013 Aug; 250():230-7. PubMed ID: 23685322
[TBL] [Abstract][Full Text] [Related]
14. [Role of NO-cGMP-PKG axis in pulmonary arterial hypertension].
Watanabe H
Nihon Yakurigaku Zasshi; 2022; 157(4):221-225. PubMed ID: 35781448
[TBL] [Abstract][Full Text] [Related]
15. Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders.
Samidurai A; Xi L; Das A; Kukreja RC
Annu Rev Pharmacol Toxicol; 2023 Jan; 63():585-615. PubMed ID: 36206989
[TBL] [Abstract][Full Text] [Related]
16. Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
Sánchez-Arias JA; Rabal O; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; Ugarte A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
ACS Chem Neurosci; 2017 Mar; 8(3):638-661. PubMed ID: 27936591
[TBL] [Abstract][Full Text] [Related]
17. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.
Sierksma AS; van den Hove DL; Pfau F; Philippens M; Bruno O; Fedele E; Ricciarelli R; Steinbusch HW; Vanmierlo T; Prickaerts J
Neuropharmacology; 2014 Feb; 77():120-30. PubMed ID: 24067928
[TBL] [Abstract][Full Text] [Related]
18. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.
García-Barroso C; Ricobaraza A; Pascual-Lucas M; Unceta N; Rico AJ; Goicolea MA; Sallés J; Lanciego JL; Oyarzabal J; Franco R; Cuadrado-Tejedor M; García-Osta A
Neuropharmacology; 2013 Jan; 64():114-23. PubMed ID: 22776546
[TBL] [Abstract][Full Text] [Related]
19. PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery.
Andersson KE
Br J Pharmacol; 2018 Jul; 175(13):2554-2565. PubMed ID: 29667180
[TBL] [Abstract][Full Text] [Related]
20. Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Rabal O; Sánchez-Arias JA; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; García-Barroso C; Ugarte A; Estella-Hermoso de Mendoza A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
J Med Chem; 2016 Oct; 59(19):8967-9004. PubMed ID: 27606546
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
