These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

252 related articles for article (PubMed ID: 31998988)

  • 1. Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
    Jewel Y; Van Dinh Q; Liu J; Dutta P
    Proteins; 2020 Jul; 88(7):853-864. PubMed ID: 31998988
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Coarse-grained simulations of conformational changes in the multidrug efflux transporter AcrB.
    Jewel Y; Liu J; Dutta P
    Mol Biosyst; 2017 Sep; 13(10):2006-2014. PubMed ID: 28770910
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.
    Yue Z; Chen W; Zgurskaya HI; Shen J
    J Chem Theory Comput; 2017 Dec; 13(12):6405-6414. PubMed ID: 29117682
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.
    Seeger MA; Diederichs K; Eicher T; Brandstätter L; Schiefner A; Verrey F; Pos KM
    Curr Drug Targets; 2008 Sep; 9(9):729-49. PubMed ID: 18781920
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional rotation induced by alternating protonation states in the multidrug transporter AcrB: all-atom molecular dynamics simulations.
    Yamane T; Murakami S; Ikeguchi M
    Biochemistry; 2013 Oct; 52(43):7648-58. PubMed ID: 24083838
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
    Plé C; Tam HK; Vieira Da Cruz A; Compagne N; Jiménez-Castellanos JC; Müller RT; Pradel E; Foong WE; Malloci G; Ballée A; Kirchner MA; Moshfegh P; Herledan A; Herrmann A; Deprez B; Willand N; Vargiu AV; Pos KM; Flipo M; Hartkoorn RC
    Nat Commun; 2022 Jan; 13(1):115. PubMed ID: 35013254
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations.
    Feng Z; Hou T; Li Y
    Mol Biosyst; 2012 Oct; 8(10):2699-709. PubMed ID: 22825052
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of
    Atzori A; Malloci G; Cardamone F; Bosin A; Vargiu AV; Ruggerone P
    Int J Mol Sci; 2020 Jan; 21(3):. PubMed ID: 32013182
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.
    Su CC; Li M; Gu R; Takatsuka Y; McDermott G; Nikaido H; Yu EW
    J Bacteriol; 2006 Oct; 188(20):7290-6. PubMed ID: 17015668
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
    Sjuts H; Vargiu AV; Kwasny SM; Nguyen ST; Kim HS; Ding X; Ornik AR; Ruggerone P; Bowlin TL; Nikaido H; Pos KM; Opperman TJ
    Proc Natl Acad Sci U S A; 2016 Mar; 113(13):3509-14. PubMed ID: 26976576
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
    Reading E; Ahdash Z; Fais C; Ricci V; Wang-Kan X; Grimsey E; Stone J; Malloci G; Lau AM; Findlay H; Konijnenberg A; Booth PJ; Ruggerone P; Vargiu AV; Piddock LJV; Politis A
    Nat Commun; 2020 Nov; 11(1):5565. PubMed ID: 33149158
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli.
    Husain F; Bikhchandani M; Nikaido H
    J Bacteriol; 2011 Oct; 193(20):5847-9. PubMed ID: 21856849
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Computer simulations suggest direct and stable tip to tip interaction between the outer membrane channel TolC and the isolated docking domain of the multidrug RND efflux transporter AcrB.
    Schmidt TH; Raunest M; Fischer N; Reith D; Kandt C
    Biochim Biophys Acta; 2016 Jul; 1858(7 Pt A):1419-26. PubMed ID: 27045078
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism.
    Takatsuka Y; Nikaido H
    J Bacteriol; 2009 Mar; 191(6):1729-37. PubMed ID: 19060146
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.
    Cha HJ; Müller RT; Pos KM
    Antimicrob Agents Chemother; 2014 Aug; 58(8):4767-72. PubMed ID: 24914123
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump.
    Vargiu AV; Ramaswamy VK; Malvacio I; Malloci G; Kleinekathöfer U; Ruggerone P
    Biochim Biophys Acta Gen Subj; 2018 Apr; 1862(4):836-845. PubMed ID: 29339082
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network.
    Takatsuka Y; Nikaido H
    J Bacteriol; 2006 Oct; 188(20):7284-9. PubMed ID: 17015667
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux.
    Vergalli J; Atzori A; Pajovic J; Dumont E; Malloci G; Masi M; Vargiu AV; Winterhalter M; Réfrégiers M; Ruggerone P; Pagès JM
    Commun Biol; 2020 Apr; 3(1):198. PubMed ID: 32346058
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Allosteric drug transport mechanism of multidrug transporter AcrB.
    Tam HK; Foong WE; Oswald C; Herrmann A; Zeng H; Pos KM
    Nat Commun; 2021 Jun; 12(1):3889. PubMed ID: 34188038
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.
    Soparkar K; Kinana AD; Weeks JW; Morrison KD; Nikaido H; Misra R
    J Bacteriol; 2015 Oct; 197(20):3255-64. PubMed ID: 26240069
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.