These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

89 related articles for article (PubMed ID: 3200837)

  • 1. A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase.
    Singh UC; Benkovic SJ
    Proc Natl Acad Sci U S A; 1988 Dec; 85(24):9519-23. PubMed ID: 3200837
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.
    Taira K; Benkovic SJ
    J Med Chem; 1988 Jan; 31(1):129-37. PubMed ID: 3275776
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.
    Singh UC
    Proc Natl Acad Sci U S A; 1988 Jun; 85(12):4280-4. PubMed ID: 3380791
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
    Chunduru SK; Appleman JR; Blakley RL
    Adv Exp Med Biol; 1993; 338():507-10. PubMed ID: 8304168
    [No Abstract]   [Full Text] [Related]  

  • 5. Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis.
    Murphy DJ; Benkovic SJ
    Biochemistry; 1989 Apr; 28(7):3025-31. PubMed ID: 2663066
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.
    Fierke CA; Benkovic SJ
    Biochemistry; 1989 Jan; 28(2):478-86. PubMed ID: 2496745
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Methotrexate binding to dihydrofolate reductase.
    Roberts GC; Feeney J; Birdsall B; Charlton P; Young D
    Nature; 1980 Jul; 286(5770):309. PubMed ID: 7402318
    [No Abstract]   [Full Text] [Related]  

  • 8. Structure, energetics and dynamics of ligand binding to dihydrofolate reductase.
    Dauber P; Osguthorpe DJ; Hagler AT
    Biochem Soc Trans; 1982 Oct; 10(5):312-8. PubMed ID: 7141085
    [No Abstract]   [Full Text] [Related]  

  • 9. Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII.
    Dicker AP; Volkenandt M; Schweitzer BI; Banerjee D; Bertino JR
    J Biol Chem; 1990 May; 265(14):8317-21. PubMed ID: 2335526
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase.
    Mayer RJ; Chen JT; Taira K; Fierke CA; Benkovic SJ
    Proc Natl Acad Sci U S A; 1986 Oct; 83(20):7718-20. PubMed ID: 3463995
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions.
    Chunduru SK; Cody V; Luft JR; Pangborn W; Appleman JR; Blakley RL
    J Biol Chem; 1994 Apr; 269(13):9547-55. PubMed ID: 8144541
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Active site-directed double mutants of dihydrofolate reductase.
    Ercikan-Abali EA; Mineishi S; Tong Y; Nakahara S; Waltham MC; Banerjee D; Chen W; Sadelain M; Bertino JR
    Cancer Res; 1996 Sep; 56(18):4142-5. PubMed ID: 8797582
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Models for the binding of methotrexate to Escherichia coli dihydrofolate reductase: direct effect of carboxylate of aspartic acid 27 upon ultraviolet spectrum of methotrexate.
    Schlegel HB; Poe M; Hoogsteen K
    Mol Pharmacol; 1981 Jul; 20(1):154-8. PubMed ID: 7027022
    [No Abstract]   [Full Text] [Related]  

  • 14. Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro.
    Matherly LH; Fry DW; Goldman ID
    Cancer Res; 1983 Jun; 43(6):2694-9. PubMed ID: 6189586
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.
    Cameron CE; Benkovic SJ
    Biochemistry; 1997 Dec; 36(50):15792-800. PubMed ID: 9398309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Very empirical treatment of solvation and entropy: a force field derived from log Po/w.
    Kellogg GE; Burnett JC; Abraham DJ
    J Comput Aided Mol Des; 2001 Apr; 15(4):381-93. PubMed ID: 11349819
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.
    Volpato JP; Fossati E; Pelletier JN
    J Mol Biol; 2007 Oct; 373(3):599-611. PubMed ID: 17868689
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies.
    Subramanian S; Kaufman BT
    Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3201-5. PubMed ID: 28523
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
    Matherly LH; Barlowe CK; Goldman ID
    Cancer Res; 1986 Feb; 46(2):588-93. PubMed ID: 2416428
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dialkyl esters of methotrexate and 3',5'-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase.
    Johns DG; Farquhar D; Wolpert MK; Chabner BA; Loo TL
    Drug Metab Dispos; 1973; 1(3):580-9. PubMed ID: 4149453
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 5.