BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 32013182)

  • 1. Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of
    Atzori A; Malloci G; Cardamone F; Bosin A; Vargiu AV; Ruggerone P
    Int J Mol Sci; 2020 Jan; 21(3):. PubMed ID: 32013182
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and characterization of carbapenem binding sites within the RND-transporter AcrB.
    Atzori A; Malviya VN; Malloci G; Dreier J; Pos KM; Vargiu AV; Ruggerone P
    Biochim Biophys Acta Biomembr; 2019 Jan; 1861(1):62-74. PubMed ID: 30416087
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump.
    Grimsey EM; Fais C; Marshall RL; Ricci V; Ciusa ML; Stone JW; Ivens A; Malloci G; Ruggerone P; Vargiu AV; Piddock LJV
    mBio; 2020 Jun; 11(3):. PubMed ID: 32487753
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
    Sjuts H; Vargiu AV; Kwasny SM; Nguyen ST; Kim HS; Ding X; Ornik AR; Ruggerone P; Bowlin TL; Nikaido H; Pos KM; Opperman TJ
    Proc Natl Acad Sci U S A; 2016 Mar; 113(13):3509-14. PubMed ID: 26976576
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular Interactions of Cephalosporins with the Deep Binding Pocket of the RND Transporter AcrB.
    Atzori A; Malloci G; Prajapati JD; Basciu A; Bosin A; Kleinekathöfer U; Dreier J; Vargiu AV; Ruggerone P
    J Phys Chem B; 2019 Jun; 123(22):4625-4635. PubMed ID: 31070373
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Computer simulations suggest direct and stable tip to tip interaction between the outer membrane channel TolC and the isolated docking domain of the multidrug RND efflux transporter AcrB.
    Schmidt TH; Raunest M; Fischer N; Reith D; Kandt C
    Biochim Biophys Acta; 2016 Jul; 1858(7 Pt A):1419-26. PubMed ID: 27045078
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium.
    Wang-Kan X; Rodríguez-Blanco G; Southam AD; Winder CL; Dunn WB; Ivens A; Piddock LJV
    mBio; 2021 Mar; 12(2):. PubMed ID: 33785633
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
    Jewel Y; Van Dinh Q; Liu J; Dutta P
    Proteins; 2020 Jul; 88(7):853-864. PubMed ID: 31998988
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular basis for the different interactions of congeneric substrates with the polyspecific transporter AcrB.
    Malvacio I; Buonfiglio R; D'Atanasio N; Serra G; Bosin A; Di Giorgio FP; Ruggerone P; Ombrato R; Vargiu AV
    Biochim Biophys Acta Biomembr; 2019 Jul; 1861(7):1397-1408. PubMed ID: 31075229
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.
    Vargiu AV; Nikaido H
    Proc Natl Acad Sci U S A; 2012 Dec; 109(50):20637-42. PubMed ID: 23175790
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
    Reading E; Ahdash Z; Fais C; Ricci V; Wang-Kan X; Grimsey E; Stone J; Malloci G; Lau AM; Findlay H; Konijnenberg A; Booth PJ; Ruggerone P; Vargiu AV; Piddock LJV; Politis A
    Nat Commun; 2020 Nov; 11(1):5565. PubMed ID: 33149158
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Escherichia coli resistance mechanism AcrAB-TolC efflux pump interactions with commonly used antibiotics: a molecular dynamics study.
    Smith BL; Fernando S; King MD
    Sci Rep; 2024 Feb; 14(1):2742. PubMed ID: 38302495
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump.
    Vargiu AV; Ramaswamy VK; Malvacio I; Malloci G; Kleinekathöfer U; Ruggerone P
    Biochim Biophys Acta Gen Subj; 2018 Apr; 1862(4):836-845. PubMed ID: 29339082
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.
    Soparkar K; Kinana AD; Weeks JW; Morrison KD; Nikaido H; Misra R
    J Bacteriol; 2015 Oct; 197(20):3255-64. PubMed ID: 26240069
    [TBL] [Abstract][Full Text] [Related]  

  • 15. AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters.
    Hayashi K; Nakashima R; Sakurai K; Kitagawa K; Yamasaki S; Nishino K; Yamaguchi A
    J Bacteriol; 2016 Jan; 198(2):332-42. PubMed ID: 26527645
    [TBL] [Abstract][Full Text] [Related]  

  • 16. RND efflux pumps: structural information translated into function and inhibition mechanisms.
    Ruggerone P; Murakami S; Pos KM; Vargiu AV
    Curr Top Med Chem; 2013; 13(24):3079-100. PubMed ID: 24200360
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
    Ornik-Cha A; Wilhelm J; Kobylka J; Sjuts H; Vargiu AV; Malloci G; Reitz J; Seybert A; Frangakis AS; Pos KM
    Nat Commun; 2021 Nov; 12(1):6919. PubMed ID: 34824229
    [TBL] [Abstract][Full Text] [Related]  

  • 18. AcrB: a mean, keen, drug efflux machine.
    Kobylka J; Kuth MS; Müller RT; Geertsma ER; Pos KM
    Ann N Y Acad Sci; 2020 Jan; 1459(1):38-68. PubMed ID: 31588569
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.
    Mowla R; Wang Y; Ma S; Venter H
    Biochim Biophys Acta Biomembr; 2018 Apr; 1860(4):878-886. PubMed ID: 28890187
    [TBL] [Abstract][Full Text] [Related]  

  • 20. AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.
    Blair JM; Bavro VN; Ricci V; Modi N; Cacciotto P; Kleinekathӧfer U; Ruggerone P; Vargiu AV; Baylay AJ; Smith HE; Brandon Y; Galloway D; Piddock LJ
    Proc Natl Acad Sci U S A; 2015 Mar; 112(11):3511-6. PubMed ID: 25737552
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.