330 related articles for article (PubMed ID: 32029588)
1. Lack of RAN-mediated toxicity in Huntington's disease knock-in mice.
Yang S; Yang H; Huang L; Chen L; Qin Z; Li S; Li XJ
Proc Natl Acad Sci U S A; 2020 Feb; 117(8):4411-4417. PubMed ID: 32029588
[TBL] [Abstract][Full Text] [Related]
2. A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Aldous SG; Smith EJ; Landles C; Osborne GF; Cañibano-Pico M; Nita IM; Phillips J; Zhang Y; Jin B; Hirst MB; Benn CL; Bond BC; Edelmann W; Greene JR; Bates GP
Brain; 2024 May; 147(5):1784-1798. PubMed ID: 38387080
[TBL] [Abstract][Full Text] [Related]
3. PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions.
Rudich P; Watkins S; Lamitina T
PLoS One; 2020; 15(4):e0227464. PubMed ID: 32240172
[TBL] [Abstract][Full Text] [Related]
4. Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
Gu X; Richman J; Langfelder P; Wang N; Zhang S; Bañez-Coronel M; Wang HB; Yang L; Ramanathan L; Deng L; Park CS; Choi CR; Cantle JP; Gao F; Gray M; Coppola G; Bates GP; Ranum LPW; Horvath S; Colwell CS; Yang XW
Neuron; 2022 Apr; 110(7):1173-1192.e7. PubMed ID: 35114102
[TBL] [Abstract][Full Text] [Related]
5. CAG RNAs induce DNA damage and apoptosis by silencing
Peng S; Guo P; Lin X; An Y; Sze KH; Lau MHY; Chen ZS; Wang Q; Li W; Sun JK; Ma SY; Chan TF; Lau KF; Ngo JCK; Kwan KM; Wong CH; Lam SL; Zimmerman SC; Tuccinardi T; Zuo Z; Au-Yeung HY; Chow HM; Chan HYE
Proc Natl Acad Sci U S A; 2021 May; 118(19):. PubMed ID: 33947817
[TBL] [Abstract][Full Text] [Related]
6. Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.
Neto JL; Lee JM; Afridi A; Gillis T; Guide JR; Dempsey S; Lager B; Alonso I; Wheeler VC; Pinto RM
Genetics; 2017 Feb; 205(2):503-516. PubMed ID: 27913616
[TBL] [Abstract][Full Text] [Related]
7. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Loupe JM; Pinto RM; Kim KH; Gillis T; Mysore JS; Andrew MA; Kovalenko M; Murtha R; Seong I; Gusella JF; Kwak S; Howland D; Lee R; Lee JM; Wheeler VC; MacDonald ME
Hum Mol Genet; 2020 Nov; 29(18):3044-3053. PubMed ID: 32876667
[TBL] [Abstract][Full Text] [Related]
8. Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis.
Pan Y; Lu J; Feng X; Lu S; Yang Y; Yang G; Tan S; Wang L; Li P; Luo S; Lu B
Nat Chem Biol; 2023 Nov; 19(11):1372-1383. PubMed ID: 37592155
[TBL] [Abstract][Full Text] [Related]
9. Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells.
Lorincz MT; Zawistowski VA
Mol Cell Neurosci; 2009 Jan; 40(1):1-13. PubMed ID: 18625318
[TBL] [Abstract][Full Text] [Related]
10. Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.
Rising AC; Xu J; Carlson A; Napoli VV; Denovan-Wright EM; Mandel RJ
Exp Neurol; 2011 Apr; 228(2):173-82. PubMed ID: 21192926
[TBL] [Abstract][Full Text] [Related]
11. RNA toxicity induced by expanded CAG repeats in Huntington's disease.
Martí E
Brain Pathol; 2016 Nov; 26(6):779-786. PubMed ID: 27529325
[TBL] [Abstract][Full Text] [Related]
12. Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.
Zhang X; Abels ER; Redzic JS; Margulis J; Finkbeiner S; Breakefield XO
Cell Mol Neurobiol; 2016 Apr; 36(3):459-70. PubMed ID: 26951563
[TBL] [Abstract][Full Text] [Related]
13. Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Rué L; Bañez-Coronel M; Creus-Muncunill J; Giralt A; Alcalá-Vida R; Mentxaka G; Kagerbauer B; Zomeño-Abellán MT; Aranda Z; Venturi V; Pérez-Navarro E; Estivill X; Martí E
J Clin Invest; 2016 Nov; 126(11):4319-4330. PubMed ID: 27721240
[TBL] [Abstract][Full Text] [Related]
14. Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.
Conforti P; Camnasio S; Mutti C; Valenza M; Thompson M; Fossale E; Zeitlin S; MacDonald ME; Zuccato C; Cattaneo E
Neurobiol Dis; 2013 Feb; 50():160-70. PubMed ID: 23089356
[TBL] [Abstract][Full Text] [Related]
15. Introducing an Expanded Trinucleotide Repeat Tract into the Human Genome for Huntington's Disease Modeling In Vitro.
Malankhanova T; Sorokin M; Medvedev S; Zakian S; Malakhova A
Curr Protoc Hum Genet; 2020 Jun; 106(1):e100. PubMed ID: 32469433
[TBL] [Abstract][Full Text] [Related]
16. Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Das MR; Chang Y; Anderson R; Saunders RA; Zhang N; Tomberlin CP; Vale RD; Jain A
Proc Natl Acad Sci U S A; 2023 Jan; 120(3):e2215071120. PubMed ID: 36623192
[TBL] [Abstract][Full Text] [Related]
17. Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.
Ishiguro H; Yamada K; Sawada H; Nishii K; Ichino N; Sawada M; Kurosawa Y; Matsushita N; Kobayashi K; Goto J; Hashida H; Masuda N; Kanazawa I; Nagatsu T
J Neurosci Res; 2001 Aug; 65(4):289-97. PubMed ID: 11494364
[TBL] [Abstract][Full Text] [Related]
18. RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Jazurek-Ciesiolka M; Ciesiolka A; Komur AA; Urbanek-Trzeciak MO; Krzyzosiak WJ; Fiszer A
J Mol Biol; 2020 Dec; 432(24):166699. PubMed ID: 33157084
[TBL] [Abstract][Full Text] [Related]
19. Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.
Lee JM; Pinto RM; Gillis T; St Claire JC; Wheeler VC
PLoS One; 2011; 6(8):e23647. PubMed ID: 21897851
[TBL] [Abstract][Full Text] [Related]
20. Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Franich NR; Hickey MA; Zhu C; Osborne GF; Ali N; Chu T; Bove NH; Lemesre V; Lerner RP; Zeitlin SO; Howland D; Neueder A; Landles C; Bates GP; Chesselet MF
J Neurosci Res; 2019 Dec; 97(12):1590-1605. PubMed ID: 31282030
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]