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2. Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer. Englinger B; Kallus S; Senkiv J; Heilos D; Gabler L; van Schoonhoven S; Terenzi A; Moser P; Pirker C; Timelthaler G; Jäger W; Kowol CR; Heffeter P; Grusch M; Berger W J Exp Clin Cancer Res; 2017 Sep; 36(1):122. PubMed ID: 28882160 [TBL] [Abstract][Full Text] [Related]
3. Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. Singleton KR; Hinz TK; Kleczko EK; Marek LA; Kwak J; Harp T; Kim J; Tan AC; Heasley LE Cancer Res; 2015 Oct; 75(20):4398-406. PubMed ID: 26359452 [TBL] [Abstract][Full Text] [Related]
4. Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1. Ren M; Hong M; Liu G; Wang H; Patel V; Biddinger P; Silva J; Cowell J; Hao Z Oncol Rep; 2013 Jun; 29(6):2181-90. PubMed ID: 23563700 [TBL] [Abstract][Full Text] [Related]
5. Preselection of Lung Cancer Cases Using FGFR1 mRNA and Gene Copy Number for Treatment With Ponatinib. Ng TL; Yu H; Smith DE; Boyle TA; York ER; Leedy S; Gao D; Aisner DL; Van Bokhoven A; Heasley LE; Hirsch FR; Camidge DR Clin Lung Cancer; 2019 Jan; 20(1):e39-e51. PubMed ID: 30297175 [TBL] [Abstract][Full Text] [Related]
6. Ponatinib: A new tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Shamroe CL; Comeau JM Ann Pharmacother; 2013 Nov; 47(11):1540-6. PubMed ID: 24265264 [TBL] [Abstract][Full Text] [Related]
7. Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo. Li H; Wang Y; Chen Z; Lu J; Pan J; Yu Y; Zhao Y; Zhang H; Hu T; Liu Q; Yang J Oncotarget; 2017 Jan; 8(4):5874-5884. PubMed ID: 27564113 [TBL] [Abstract][Full Text] [Related]
8. Ponatinib (AP24534) is a novel potent inhibitor of oncogenic RET mutants associated with thyroid cancer. De Falco V; Buonocore P; Muthu M; Torregrossa L; Basolo F; Billaud M; Gozgit JM; Carlomagno F; Santoro M J Clin Endocrinol Metab; 2013 May; 98(5):E811-9. PubMed ID: 23526464 [TBL] [Abstract][Full Text] [Related]
12. Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities. Ren M; Qin H; Ren R; Cowell JK Leukemia; 2013 Jan; 27(1):32-40. PubMed ID: 22781593 [TBL] [Abstract][Full Text] [Related]
13. Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition. Lang JD; Hendricks WPD; Orlando KA; Yin H; Kiefer J; Ramos P; Sharma R; Pirrotte P; Raupach EA; Sereduk C; Tang N; Liang WS; Washington M; Facista SJ; Zismann VL; Cousins EM; Major MB; Wang Y; Karnezis AN; Sekulic A; Hass R; Vanderhyden BC; Nair P; Weissman BE; Huntsman DG; Trent JM Clin Cancer Res; 2018 Apr; 24(8):1932-1943. PubMed ID: 29440177 [No Abstract] [Full Text] [Related]
14. Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. Gozgit JM; Wong MJ; Moran L; Wardwell S; Mohemmad QK; Narasimhan NI; Shakespeare WC; Wang F; Clackson T; Rivera VM Mol Cancer Ther; 2012 Mar; 11(3):690-9. PubMed ID: 22238366 [TBL] [Abstract][Full Text] [Related]
15. Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets. Kanojia D; Garg M; Martinez J; M T A; Luty SB; Doan NB; Said JW; Forscher C; Tyner JW; Koeffler HP J Hematol Oncol; 2017 Nov; 10(1):173. PubMed ID: 29132397 [TBL] [Abstract][Full Text] [Related]
16. Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas. Cowell JK; Qin H; Hu T; Wu Q; Bhole A; Ren M Int J Cancer; 2017 Nov; 141(9):1822-1829. PubMed ID: 28646488 [TBL] [Abstract][Full Text] [Related]
17. Pharmacokinetic Assessment of Cooperative Efflux of the Multitargeted Kinase Inhibitor Ponatinib Across the Blood-Brain Barrier. Laramy JK; Kim M; Parrish KE; Sarkaria JN; Elmquist WF J Pharmacol Exp Ther; 2018 May; 365(2):249-261. PubMed ID: 29440450 [TBL] [Abstract][Full Text] [Related]
19. A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib. Yandim MK; Ceylan C; Elmas E; Baran Y Tumour Biol; 2016 Feb; 37(2):2365-78. PubMed ID: 26373734 [TBL] [Abstract][Full Text] [Related]
20. Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Gozgit JM; Squillace RM; Wongchenko MJ; Miller D; Wardwell S; Mohemmad Q; Narasimhan NI; Wang F; Clackson T; Rivera VM Cancer Chemother Pharmacol; 2013 May; 71(5):1315-23. PubMed ID: 23468082 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]