BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 32067263)

  • 1. FCX-146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second-generation arylidene indanone scaffold.
    Balasubramaniam M; Lakkaniga NR; Dera AA; Fayi MA; Abohashrh M; Ahmad I; Chandramoorthy HC; Nalini G; Rajagopalan P
    Biotechnol Appl Biochem; 2021 Feb; 68(1):82-91. PubMed ID: 32067263
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancer.
    Rajagopalan P; Alahmari KA; Elbessoumy AA; Balasubramaniam M; Suresh R; Shariff ME; Chandramoorthy HC
    Cancer Chemother Pharmacol; 2016 Feb; 77(2):393-404. PubMed ID: 26781309
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Microsecond molecular dynamics simulations provide insight into the ATP-competitive inhibitor-induced allosteric protection of Akt kinase phosphorylation.
    Mou L; Cui T; Liu W; Zhang H; Cai Z; Lu S; Gao G
    Chem Biol Drug Des; 2017 May; 89(5):723-731. PubMed ID: 27797456
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.
    Politz O; Siegel F; Bärfacker L; Bömer U; Hägebarth A; Scott WJ; Michels M; Ince S; Neuhaus R; Meyer K; Fernández-Montalván AE; Liu N; von Nussbaum F; Mumberg D; Ziegelbauer K
    Int J Cancer; 2017 Jan; 140(2):449-459. PubMed ID: 27699769
    [TBL] [Abstract][Full Text] [Related]  

  • 5.
    Eduardo Sanabria-Chanaga E; Betancourt-Conde I; Hernández-Campos A; Téllez-Valencia A; Castillo R
    J Biomol Struct Dyn; 2019 Oct; 37(16):4301-4311. PubMed ID: 30477412
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
    Lindsley CW; Barnett SF; Layton ME; Bilodeau MT
    Curr Cancer Drug Targets; 2008 Feb; 8(1):7-18. PubMed ID: 18288939
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells.
    Yuan CX; Zhou ZW; Yang YX; He ZX; Zhang X; Wang D; Yang T; Pan SY; Chen XW; Zhou SF
    Drug Des Devel Ther; 2015; 9():1293-318. PubMed ID: 25767376
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Developments in selective small molecule ATP-targeting the serine/threonine kinase Akt/PKB.
    Wang P; Zhang L; Hao Q; Zhao G
    Mini Rev Med Chem; 2011 Nov; 11(13):1093-107. PubMed ID: 22353219
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling.
    Zuo Y; Huang J; Zhou B; Wang S; Shao W; Zhu C; Lin L; Wen G; Wang H; Du J; Bu X
    Eur J Med Chem; 2012 Sep; 55():346-57. PubMed ID: 22889562
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma.
    Guenther MK; Graab U; Fulda S
    Cancer Lett; 2013 Sep; 337(2):200-9. PubMed ID: 23684925
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation.
    Pragna Lakshmi T; Kumar A; Vijaykumar V; Natarajan S; Krishna R
    Int J Biol Macromol; 2017 Mar; 96():200-213. PubMed ID: 27956098
    [TBL] [Abstract][Full Text] [Related]  

  • 12. FCX, an arylidene derivative, induces apoptosis in androgen receptor-selective prostate cancer cells.
    Prasanna R; Elbessoumy AA; Chandramoorthy HC; Dera A; Al Fayi M
    J Cancer Res Ther; 2021; 17(2):401-407. PubMed ID: 34121684
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Probing the PI3K/Akt/mTor pathway using
    Phyu SM; Tseng CC; Fleming IN; Smith TA
    Sci Rep; 2016 Nov; 6():36544. PubMed ID: 27811956
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
    Lindsley CW; Barnett SF; Yaroschak M; Bilodeau MT; Layton ME
    Curr Top Med Chem; 2007; 7(14):1349-63. PubMed ID: 17692025
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo.
    Hirai H; Sootome H; Nakatsuru Y; Miyama K; Taguchi S; Tsujioka K; Ueno Y; Hatch H; Majumder PK; Pan BS; Kotani H
    Mol Cancer Ther; 2010 Jul; 9(7):1956-67. PubMed ID: 20571069
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The mood stabilizing properties of AF3581, a novel potent GSK-3β inhibitor.
    Capurro V; Lanfranco M; Summa M; Porceddu PF; Ciampoli M; Margaroli N; Durando L; Garrone B; Ombrato R; Tongiani S; Reggiani A
    Biomed Pharmacother; 2020 Aug; 128():110249. PubMed ID: 32470749
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation.
    Lee CJ; Jang JH; Lee JY; Lee MH; Li Y; Ryu HW; Choi KI; Dong Z; Lee HS; Oh SR; Surh YJ; Cho YY
    Carcinogenesis; 2015 Oct; 36(10):1223-34. PubMed ID: 26243309
    [TBL] [Abstract][Full Text] [Related]  

  • 18. High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors.
    Smit DJ; Cayrefourcq L; Haider MT; Hinz N; Pantel K; Alix-Panabières C; Jücker M
    Cells; 2020 Sep; 9(9):. PubMed ID: 32962206
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer.
    Baby K; Maity S; Mehta CH; Nayak UY; Shenoy GG; Pai KSR; Harikumar KB; Nayak Y
    Sci Rep; 2023 May; 13(1):7947. PubMed ID: 37193898
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma.
    Graab U; Hahn H; Fulda S
    Oncotarget; 2015 Apr; 6(11):8722-35. PubMed ID: 25749378
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.