301 related articles for article (PubMed ID: 32079767)
1. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.
Suomivuori CM; Latorraca NR; Wingler LM; Eismann S; King MC; Kleinhenz ALW; Skiba MA; Staus DP; Kruse AC; Lefkowitz RJ; Dror RO
Science; 2020 Feb; 367(6480):881-887. PubMed ID: 32079767
[TBL] [Abstract][Full Text] [Related]
2. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.
Cabana J; Holleran B; Leduc R; Escher E; Guillemette G; Lavigne P
J Biol Chem; 2015 Jun; 290(25):15835-15854. PubMed ID: 25934394
[TBL] [Abstract][Full Text] [Related]
3. Allosteric coupling and biased agonism in G protein-coupled receptors.
Bock A; Bermudez M
FEBS J; 2021 Apr; 288(8):2513-2528. PubMed ID: 33621418
[TBL] [Abstract][Full Text] [Related]
4. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Wingler LM; Skiba MA; McMahon C; Staus DP; Kleinhenz ALW; Suomivuori CM; Latorraca NR; Dror RO; Lefkowitz RJ; Kruse AC
Science; 2020 Feb; 367(6480):888-892. PubMed ID: 32079768
[TBL] [Abstract][Full Text] [Related]
5. Molecular Mechanisms of Diverse Activation Stimulated by Different Biased Agonists for the β2-Adrenergic Receptor.
Chen J; Liu J; Yuan Y; Chen X; Zhang F; Pu X
J Chem Inf Model; 2022 Nov; 62(21):5175-5192. PubMed ID: 34802238
[TBL] [Abstract][Full Text] [Related]
6. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.
Wingler LM; Elgeti M; Hilger D; Latorraca NR; Lerch MT; Staus DP; Dror RO; Kobilka BK; Hubbell WL; Lefkowitz RJ
Cell; 2019 Jan; 176(3):468-478.e11. PubMed ID: 30639099
[TBL] [Abstract][Full Text] [Related]
7. Molecular mechanism of GPCR-mediated arrestin activation.
Latorraca NR; Wang JK; Bauer B; Townshend RJL; Hollingsworth SA; Olivieri JE; Xu HE; Sommer ME; Dror RO
Nature; 2018 May; 557(7705):452-456. PubMed ID: 29720655
[TBL] [Abstract][Full Text] [Related]
8. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design.
Lu S; He X; Yang Z; Chai Z; Zhou S; Wang J; Rehman AU; Ni D; Pu J; Sun J; Zhang J
Nat Commun; 2021 Aug; 12(1):4721. PubMed ID: 34354057
[TBL] [Abstract][Full Text] [Related]
9. Recent Insights from Molecular Dynamics Simulations for G Protein-Coupled Receptor Drug Discovery.
Zou Y; Ewalt J; Ng HL
Int J Mol Sci; 2019 Aug; 20(17):. PubMed ID: 31470676
[TBL] [Abstract][Full Text] [Related]
10. Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.
Devost D; Sleno R; Pétrin D; Zhang A; Shinjo Y; Okde R; Aoki J; Inoue A; Hébert TE
J Biol Chem; 2017 Mar; 292(13):5443-5456. PubMed ID: 28213525
[TBL] [Abstract][Full Text] [Related]
11. Biased Signaling in Mutated Variants of β
Madhu MK; Shewani K; Murarka RK
J Chem Inf Model; 2024 Jan; 64(2):449-469. PubMed ID: 38194225
[TBL] [Abstract][Full Text] [Related]
12. Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist.
Magnan R; Escrieut C; Gigoux V; De K; Clerc P; Niu F; Azema J; Masri B; Cordomi A; Baltas M; Tikhonova IG; Fourmy D
J Am Chem Soc; 2013 Feb; 135(7):2560-73. PubMed ID: 23323542
[TBL] [Abstract][Full Text] [Related]
13. The role of structural dynamics in GPCR-mediated signaling.
Hilger D
FEBS J; 2021 Apr; 288(8):2461-2489. PubMed ID: 33871923
[TBL] [Abstract][Full Text] [Related]
14. Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.
Peterson SM; Pack TF; Wilkins AD; Urs NM; Urban DJ; Bass CE; Lichtarge O; Caron MG
Proc Natl Acad Sci U S A; 2015 Jun; 112(22):7097-102. PubMed ID: 25964346
[TBL] [Abstract][Full Text] [Related]
15. Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT
Denzinger K; Nguyen TN; Noonan T; Wolber G; Bermudez M
Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33419260
[TBL] [Abstract][Full Text] [Related]
16. Beta-arrestin-biased ligands at seven-transmembrane receptors.
Violin JD; Lefkowitz RJ
Trends Pharmacol Sci; 2007 Aug; 28(8):416-22. PubMed ID: 17644195
[TBL] [Abstract][Full Text] [Related]
17. Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations.
Modestia SM; Malta de Sá M; Auger E; Trossini GHG; Krieger JE; Rangel-Yagui CO
J Chem Inf Model; 2019 Feb; 59(2):797-808. PubMed ID: 30668103
[TBL] [Abstract][Full Text] [Related]
18. Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.
Peterson SM; Pack TF; Caron MG
PLoS One; 2015; 10(10):e0141637. PubMed ID: 26516769
[TBL] [Abstract][Full Text] [Related]
19. Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα
Wang J; Hanada K; Gareri C; Rockman HA
J Cell Biochem; 2018 Apr; 119(4):3586-3597. PubMed ID: 29231251
[TBL] [Abstract][Full Text] [Related]
20. Angiotensin II cyclic analogs as tools to investigate AT
St-Pierre D; Cabana J; Holleran BJ; Besserer-Offroy É; Escher E; Guillemette G; Lavigne P; Leduc R
Biochem Pharmacol; 2018 Aug; 154():104-117. PubMed ID: 29684376
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
