BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

377 related articles for article (PubMed ID: 32079768)

  • 1. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
    Wingler LM; Skiba MA; McMahon C; Staus DP; Kleinhenz ALW; Suomivuori CM; Latorraca NR; Dror RO; Lefkowitz RJ; Kruse AC
    Science; 2020 Feb; 367(6480):888-892. PubMed ID: 32079768
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Angiotensin II cyclic analogs as tools to investigate AT
    St-Pierre D; Cabana J; Holleran BJ; Besserer-Offroy É; Escher E; Guillemette G; Lavigne P; Leduc R
    Biochem Pharmacol; 2018 Aug; 154():104-117. PubMed ID: 29684376
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
    Tang W; Strachan RT; Lefkowitz RJ; Rockman HA
    J Biol Chem; 2014 Oct; 289(41):28271-83. PubMed ID: 25170081
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.
    Li A; Liu S; Huang R; Ahn S; Lefkowitz RJ
    PLoS One; 2023; 18(3):e0283477. PubMed ID: 36961836
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biased agonists differentially modulate the receptor conformation ensembles in Angiotensin II type 1 receptor.
    Nivedha AK; Lee S; Vaidehi N
    J Mol Graph Model; 2023 Jan; 118():108365. PubMed ID: 36335829
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.
    Cabana J; Holleran B; Leduc R; Escher E; Guillemette G; Lavigne P
    J Biol Chem; 2015 Jun; 290(25):15835-15854. PubMed ID: 25934394
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.
    Wingler LM; Elgeti M; Hilger D; Latorraca NR; Lerch MT; Staus DP; Dror RO; Kobilka BK; Hubbell WL; Lefkowitz RJ
    Cell; 2019 Jan; 176(3):468-478.e11. PubMed ID: 30639099
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.
    Zimmerman B; Beautrait A; Aguila B; Charles R; Escher E; Claing A; Bouvier M; Laporte SA
    Sci Signal; 2012 Apr; 5(221):ra33. PubMed ID: 22534132
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology.
    Braga Emidio N; Small BM; Keller AR; Cheloha RW; Wingler LM
    Mol Pharmacol; 2024 Feb; 105(3):260-271. PubMed ID: 38164609
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biased agonism of the angiotensin II type 1 receptor.
    Godin CM; Ferguson SS
    Mini Rev Med Chem; 2012 Aug; 12(9):812-6. PubMed ID: 22681254
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
    Kawakami K; Yanagawa M; Hiratsuka S; Yoshida M; Ono Y; Hiroshima M; Ueda M; Aoki J; Sako Y; Inoue A
    Nat Commun; 2022 Jan; 13(1):487. PubMed ID: 35078997
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Adrenal angiotensin II type 1 receptor biased signaling: The case for "biased" inverse agonism for effective aldosterone suppression.
    Ferraino KE; Cora N; Pollard CM; Sizova A; Maning J; Lymperopoulos A
    Cell Signal; 2021 Jun; 82():109967. PubMed ID: 33640432
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses.
    Lavenus S; Simard É; Besserer-Offroy É; Froehlich U; Leduc R; Grandbois M
    Pharmacol Res; 2018 Oct; 136():108-120. PubMed ID: 29959993
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor.
    Gagnon L; Cao Y; Cho A; Sedki D; Huber T; Sakmar TP; Laporte SA
    J Biol Chem; 2019 Nov; 294(46):17409-17420. PubMed ID: 31530642
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.
    Namkung Y; LeGouill C; Kumar S; Cao Y; Teixeira LB; Lukasheva V; Giubilaro J; Simões SC; Longpré JM; Devost D; Hébert TE; Piñeyro G; Leduc R; Costa-Neto CM; Bouvier M; Laporte SA
    Sci Signal; 2018 Dec; 11(559):. PubMed ID: 30514808
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
    Zhang D; Liu Y; Zaidi SA; Xu L; Zhan Y; Chen A; Guo J; Huang XP; Roth BL; Katritch V; Cherezov V; Zhang H
    EMBO J; 2023 Jun; 42(11):e112940. PubMed ID: 37038975
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
    Wingler LM; McMahon C; Staus DP; Lefkowitz RJ; Kruse AC
    Cell; 2019 Jan; 176(3):479-490.e12. PubMed ID: 30639100
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα
    Wang J; Hanada K; Gareri C; Rockman HA
    J Cell Biochem; 2018 Apr; 119(4):3586-3597. PubMed ID: 29231251
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
    Shukla AK; Violin JD; Whalen EJ; Gesty-Palmer D; Shenoy SK; Lefkowitz RJ
    Proc Natl Acad Sci U S A; 2008 Jul; 105(29):9988-93. PubMed ID: 18621717
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Single-molecule force spectroscopy study of interactions between angiotensin II type 1 receptor and different biased ligands in living cells.
    Li W; Xu J; Kou X; Zhao R; Zhou W; Fang X
    Anal Bioanal Chem; 2018 May; 410(14):3275-3284. PubMed ID: 29492619
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.