These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 32079772)

  • 1. Ancient origins of allosteric activation in a Ser-Thr kinase.
    Hadzipasic A; Wilson C; Nguyen V; Kern N; Kim C; Pitsawong W; Villali J; Zheng Y; Kern D
    Science; 2020 Feb; 367(6480):912-917. PubMed ID: 32079772
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2.
    Zorba A; Buosi V; Kutter S; Kern N; Pontiggia F; Cho YJ; Kern D
    Elife; 2014 May; 3():e02667. PubMed ID: 24867643
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.
    Rennie YK; McIntyre PJ; Akindele T; Bayliss R; Jamieson AG
    ACS Chem Biol; 2016 Dec; 11(12):3383-3390. PubMed ID: 27775325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
    Panicker RC; Coyne AG; Srinivasan R
    Curr Med Chem; 2019; 26(13):2234-2242. PubMed ID: 28748768
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Abrogation of AuroraA-TPX2 by novel natural inhibitors: molecular dynamics-based mechanistic analysis.
    Gupta A; Jain R; Wahi D; Goyal S; Jamal S; Grover A
    J Recept Signal Transduct Res; 2015; 35(6):626-33. PubMed ID: 26390942
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.
    Gomes-Filho SM; Dos Santos EO; Bertoldi ERM; Scalabrini LC; Heidrich V; Dazzani B; Levantini E; Reis EM; Bassères DS
    Cell Oncol (Dordr); 2020 Jun; 43(3):445-460. PubMed ID: 32193808
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
    Janeček M; Rossmann M; Sharma P; Emery A; Huggins DJ; Stockwell SR; Stokes JE; Tan YS; Almeida EG; Hardwick B; Narvaez AJ; Hyvönen M; Spring DR; McKenzie GJ; Venkitaraman AR
    Sci Rep; 2016 Jun; 6():28528. PubMed ID: 27339427
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.
    Chen H; Mohan P; Jiang J; Nemirovsky O; He D; Fleisch MC; Niederacher D; Pilarski LM; Lim CJ; Maxwell CA
    Cell Cycle; 2014; 13(14):2248-61. PubMed ID: 24875404
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Response to Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
    Wilson C; Kern D
    Science; 2020 Nov; 370(6519):. PubMed ID: 33214247
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
    McIntyre PJ; Collins PM; Vrzal L; Birchall K; Arnold LH; Mpamhanga C; Coombs PJ; Burgess SG; Richards MW; Winter A; Veverka V; Delft FV; Merritt A; Bayliss R
    ACS Chem Biol; 2017 Nov; 12(11):2906-2914. PubMed ID: 29045126
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
    Lake EW; Muretta JM; Thompson AR; Rasmussen DM; Majumdar A; Faber EB; Ruff EF; Thomas DD; Levinson NM
    Proc Natl Acad Sci U S A; 2018 Dec; 115(51):E11894-E11903. PubMed ID: 30518564
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel mechanism for activation of the protein kinase Aurora A.
    Eyers PA; Erikson E; Chen LG; Maller JL
    Curr Biol; 2003 Apr; 13(8):691-7. PubMed ID: 12699628
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of Xenopus Aurora A activation by TPX2.
    Eyers PA; Maller JL
    J Biol Chem; 2004 Mar; 279(10):9008-15. PubMed ID: 14701852
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.
    Lee SY; Kim EY; Kim KH; Lee KA
    Cell Cycle; 2016 Dec; 15(23):3296-3305. PubMed ID: 27753540
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Switching Aurora-A kinase on and off at an allosteric site.
    Bayliss R; Burgess SG; McIntyre PJ
    FEBS J; 2017 Sep; 284(18):2947-2954. PubMed ID: 28342286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.
    Asteriti IA; Daidone F; Colotti G; Rinaldo S; Lavia P; Guarguaglini G; Paiardini A
    Oncotarget; 2017 May; 8(19):32117-32133. PubMed ID: 28389630
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.
    Kreis NN; Steinhäuser K; Ritter A; Klöble P; Hoock SC; Roth S; Louwen F; Oswald F; Yuan J
    Oncogene; 2019 May; 38(22):4199-4214. PubMed ID: 30705408
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
    Cole DJ; Janecek M; Stokes JE; Rossmann M; Faver JC; McKenzie GJ; Venkitaraman AR; Hyvönen M; Spring DR; Huggins DJ; Jorgensen WL
    Chem Commun (Camb); 2017 Aug; 53(67):9372-9375. PubMed ID: 28787041
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.
    Bertolin G; Sizaire F; Herbomel G; Reboutier D; Prigent C; Tramier M
    Nat Commun; 2016 Sep; 7():12674. PubMed ID: 27624869
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
    Park Y; Patton JEJ; Hochberg GKA; Thornton JW
    Science; 2020 Nov; 370(6519):. PubMed ID: 33214251
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.