BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

319 related articles for article (PubMed ID: 32093728)

  • 21. C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
    Licata NV; Cristofani R; Salomonsson S; Wilson KM; Kempthorne L; Vaizoglu D; D'Agostino VG; Pollini D; Loffredo R; Pancher M; Adami V; Bellosta P; Ratti A; Viero G; Quattrone A; Isaacs AM; Poletti A; Provenzani A
    EMBO J; 2022 Jan; 41(1):e105026. PubMed ID: 34791698
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis.
    Wang R; Xu X; Hao Z; Zhang S; Wu D; Sun H; Mu C; Ren H; Wang G
    Neurosci Bull; 2019 Oct; 35(5):889-900. PubMed ID: 31148094
    [TBL] [Abstract][Full Text] [Related]  

  • 23.
    Fumagalli L; Young FL; Boeynaems S; De Decker M; Mehta AR; Swijsen A; Fazal R; Guo W; Moisse M; Beckers J; Dedeene L; Selvaraj BT; Vandoorne T; Madan V; van Blitterswijk M; Raitcheva D; McCampbell A; Poesen K; Gitler AD; Koch P; Vanden Berghe P; Thal DR; Verfaillie C; Chandran S; Van Den Bosch L; Bullock SL; Van Damme P
    Sci Adv; 2021 Apr; 7(15):. PubMed ID: 33837088
    [TBL] [Abstract][Full Text] [Related]  

  • 24. C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in
    Xu W; Xu J
    J Neurosci; 2018 Aug; 38(35):7741-7752. PubMed ID: 30037833
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Translation of dipeptide repeat proteins in
    Sonobe Y; Lee S; Krishnan G; Gu Y; Kwon DY; Gao FB; Roos RP; Kratsios P
    Elife; 2023 Sep; 12():. PubMed ID: 37675986
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in
    Zhang WW; Matlashewski G
    mSphere; 2019 Aug; 4(4):. PubMed ID: 31434745
    [TBL] [Abstract][Full Text] [Related]  

  • 27. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
    Meijboom KE; Abdallah A; Fordham NP; Nagase H; Rodriguez T; Kraus C; Gendron TF; Krishnan G; Esanov R; Andrade NS; Rybin MJ; Ramic M; Stephens ZD; Edraki A; Blackwood MT; Kahriman A; Henninger N; Kocher JA; Benatar M; Brodsky MH; Petrucelli L; Gao FB; Sontheimer EJ; Brown RH; Zeier Z; Mueller C
    Nat Commun; 2022 Oct; 13(1):6286. PubMed ID: 36271076
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.
    Jensen BK; Schuldi MH; McAvoy K; Russell KA; Boehringer A; Curran BM; Krishnamurthy K; Wen X; Westergard T; Ma L; Haeusler AR; Edbauer D; Pasinelli P; Trotti D
    EMBO Mol Med; 2020 May; 12(5):e10722. PubMed ID: 32347002
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.
    Flores BN; Dulchavsky ME; Krans A; Sawaya MR; Paulson HL; Todd PK; Barmada SJ; Ivanova MI
    PLoS One; 2016; 11(10):e0165084. PubMed ID: 27776165
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases.
    Dedeene L; Van Schoor E; Vandenberghe R; Van Damme P; Poesen K; Thal DR
    Acta Neuropathol Commun; 2019 Dec; 7(1):189. PubMed ID: 31791419
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G
    Czuppa M; Dhingra A; Zhou Q; Schludi C; König L; Scharf E; Farny D; Dalmia A; Täger J; Castillo-Lizardo M; Katona E; Mori K; Aumer T; Schelter F; Müller M; Carell T; Kalliokoski T; Messinger J; Rizzu P; Heutink P; Edbauer D
    Cell Rep; 2022 Jun; 39(10):110913. PubMed ID: 35675776
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in
    Lopez-Gonzalez R; Yang D; Pribadi M; Kim TS; Krishnan G; Choi SY; Lee S; Coppola G; Gao FB
    Proc Natl Acad Sci U S A; 2019 May; 116(19):9628-9633. PubMed ID: 31019093
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
    Sonobe Y; Aburas J; Krishnan G; Fleming AC; Ghadge G; Islam P; Warren EC; Gu Y; Kankel MW; Brown AEX; Kiskinis E; Gendron TF; Gao FB; Roos RP; Kratsios P
    Nat Commun; 2021 Oct; 12(1):6025. PubMed ID: 34654821
    [TBL] [Abstract][Full Text] [Related]  

  • 34. A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
    Esanov R; Cabrera GT; Andrade NS; Gendron TF; Brown RH; Benatar M; Wahlestedt C; Mueller C; Zeier Z
    Mol Neurodegener; 2017 Jun; 12(1):46. PubMed ID: 28606110
    [TBL] [Abstract][Full Text] [Related]  

  • 35. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
    Lee YB; Baskaran P; Gomez-Deza J; Chen HJ; Nishimura AL; Smith BN; Troakes C; Adachi Y; Stepto A; Petrucelli L; Gallo JM; Hirth F; Rogelj B; Guthrie S; Shaw CE
    Hum Mol Genet; 2017 Dec; 26(24):4765-4777. PubMed ID: 28973350
    [TBL] [Abstract][Full Text] [Related]  

  • 36. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
    Moore S; Alsop E; Lorenzini I; Starr A; Rabichow BE; Mendez E; Levy JL; Burciu C; Reiman R; Chew J; Belzil VV; W Dickson D; Robertson J; Staats KA; Ichida JK; Petrucelli L; Van Keuren-Jensen K; Sattler R
    Acta Neuropathol; 2019 Jul; 138(1):49-65. PubMed ID: 30945056
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Poly(ADP-ribose) promotes toxicity of
    Gao J; Mewborne QT; Girdhar A; Sheth U; Coyne AN; Punathil R; Kang BG; Dasovich M; Veire A; DeJesus Hernandez M; Liu S; Shi Z; Dafinca R; Fouquerel E; Talbot K; Kam TI; Zhang YJ; Dickson D; Petrucelli L; van Blitterswijk M; Guo L; Dawson TM; Dawson VL; Leung AKL; Lloyd TE; Gendron TF; Rothstein JD; Zhang K
    Sci Transl Med; 2022 Sep; 14(662):eabq3215. PubMed ID: 36103513
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.
    Xu W; Bao P; Jiang X; Wang H; Qin M; Wang R; Wang T; Yang Y; Lorenzini I; Liao L; Sattler R; Xu J
    Brain; 2019 May; 142(5):1349-1364. PubMed ID: 30938419
    [TBL] [Abstract][Full Text] [Related]  

  • 39. How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.
    Van't Spijker HM; Almeida S
    Gene; 2023 Mar; 858():147167. PubMed ID: 36621656
    [TBL] [Abstract][Full Text] [Related]  

  • 40. CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.
    Guo W; Wang H; Kumar Tharkeshwar A; Couthouis J; Braems E; Masrori P; Van Schoor E; Fan Y; Ahuja K; Moisse M; Jacquemyn M; Furtado Madeiro da Costa R; Gajjar M; Balusu S; Tricot T; Fumagalli L; Hersmus N; Janky R; Impens F; Vanden Berghe P; Ho R; Thal DR; Vandenberghe R; Hegde ML; Chandran S; De Strooper B; Daelemans D; Van Damme P; Van Den Bosch L; Verfaillie C
    Alzheimers Dement; 2023 Apr; 19(4):1245-1259. PubMed ID: 35993441
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 16.