319 related articles for article (PubMed ID: 32093728)
21. C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata NV; Cristofani R; Salomonsson S; Wilson KM; Kempthorne L; Vaizoglu D; D'Agostino VG; Pollini D; Loffredo R; Pancher M; Adami V; Bellosta P; Ratti A; Viero G; Quattrone A; Isaacs AM; Poletti A; Provenzani A
EMBO J; 2022 Jan; 41(1):e105026. PubMed ID: 34791698
[TBL] [Abstract][Full Text] [Related]
22. Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis.
Wang R; Xu X; Hao Z; Zhang S; Wu D; Sun H; Mu C; Ren H; Wang G
Neurosci Bull; 2019 Oct; 35(5):889-900. PubMed ID: 31148094
[TBL] [Abstract][Full Text] [Related]
23.
Fumagalli L; Young FL; Boeynaems S; De Decker M; Mehta AR; Swijsen A; Fazal R; Guo W; Moisse M; Beckers J; Dedeene L; Selvaraj BT; Vandoorne T; Madan V; van Blitterswijk M; Raitcheva D; McCampbell A; Poesen K; Gitler AD; Koch P; Vanden Berghe P; Thal DR; Verfaillie C; Chandran S; Van Den Bosch L; Bullock SL; Van Damme P
Sci Adv; 2021 Apr; 7(15):. PubMed ID: 33837088
[TBL] [Abstract][Full Text] [Related]
24. C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in
Xu W; Xu J
J Neurosci; 2018 Aug; 38(35):7741-7752. PubMed ID: 30037833
[TBL] [Abstract][Full Text] [Related]
25. Translation of dipeptide repeat proteins in
Sonobe Y; Lee S; Krishnan G; Gu Y; Kwon DY; Gao FB; Roos RP; Kratsios P
Elife; 2023 Sep; 12():. PubMed ID: 37675986
[TBL] [Abstract][Full Text] [Related]
26. Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in
Zhang WW; Matlashewski G
mSphere; 2019 Aug; 4(4):. PubMed ID: 31434745
[TBL] [Abstract][Full Text] [Related]
27. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
Meijboom KE; Abdallah A; Fordham NP; Nagase H; Rodriguez T; Kraus C; Gendron TF; Krishnan G; Esanov R; Andrade NS; Rybin MJ; Ramic M; Stephens ZD; Edraki A; Blackwood MT; Kahriman A; Henninger N; Kocher JA; Benatar M; Brodsky MH; Petrucelli L; Gao FB; Sontheimer EJ; Brown RH; Zeier Z; Mueller C
Nat Commun; 2022 Oct; 13(1):6286. PubMed ID: 36271076
[TBL] [Abstract][Full Text] [Related]
28. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.
Jensen BK; Schuldi MH; McAvoy K; Russell KA; Boehringer A; Curran BM; Krishnamurthy K; Wen X; Westergard T; Ma L; Haeusler AR; Edbauer D; Pasinelli P; Trotti D
EMBO Mol Med; 2020 May; 12(5):e10722. PubMed ID: 32347002
[TBL] [Abstract][Full Text] [Related]
29. Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.
Flores BN; Dulchavsky ME; Krans A; Sawaya MR; Paulson HL; Todd PK; Barmada SJ; Ivanova MI
PLoS One; 2016; 11(10):e0165084. PubMed ID: 27776165
[TBL] [Abstract][Full Text] [Related]
30. Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases.
Dedeene L; Van Schoor E; Vandenberghe R; Van Damme P; Poesen K; Thal DR
Acta Neuropathol Commun; 2019 Dec; 7(1):189. PubMed ID: 31791419
[TBL] [Abstract][Full Text] [Related]
31. Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G
Czuppa M; Dhingra A; Zhou Q; Schludi C; König L; Scharf E; Farny D; Dalmia A; Täger J; Castillo-Lizardo M; Katona E; Mori K; Aumer T; Schelter F; Müller M; Carell T; Kalliokoski T; Messinger J; Rizzu P; Heutink P; Edbauer D
Cell Rep; 2022 Jun; 39(10):110913. PubMed ID: 35675776
[TBL] [Abstract][Full Text] [Related]
32. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in
Lopez-Gonzalez R; Yang D; Pribadi M; Kim TS; Krishnan G; Choi SY; Lee S; Coppola G; Gao FB
Proc Natl Acad Sci U S A; 2019 May; 116(19):9628-9633. PubMed ID: 31019093
[TBL] [Abstract][Full Text] [Related]
33. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Sonobe Y; Aburas J; Krishnan G; Fleming AC; Ghadge G; Islam P; Warren EC; Gu Y; Kankel MW; Brown AEX; Kiskinis E; Gendron TF; Gao FB; Roos RP; Kratsios P
Nat Commun; 2021 Oct; 12(1):6025. PubMed ID: 34654821
[TBL] [Abstract][Full Text] [Related]
34. A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
Esanov R; Cabrera GT; Andrade NS; Gendron TF; Brown RH; Benatar M; Wahlestedt C; Mueller C; Zeier Z
Mol Neurodegener; 2017 Jun; 12(1):46. PubMed ID: 28606110
[TBL] [Abstract][Full Text] [Related]
35. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
Lee YB; Baskaran P; Gomez-Deza J; Chen HJ; Nishimura AL; Smith BN; Troakes C; Adachi Y; Stepto A; Petrucelli L; Gallo JM; Hirth F; Rogelj B; Guthrie S; Shaw CE
Hum Mol Genet; 2017 Dec; 26(24):4765-4777. PubMed ID: 28973350
[TBL] [Abstract][Full Text] [Related]
36. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S; Alsop E; Lorenzini I; Starr A; Rabichow BE; Mendez E; Levy JL; Burciu C; Reiman R; Chew J; Belzil VV; W Dickson D; Robertson J; Staats KA; Ichida JK; Petrucelli L; Van Keuren-Jensen K; Sattler R
Acta Neuropathol; 2019 Jul; 138(1):49-65. PubMed ID: 30945056
[TBL] [Abstract][Full Text] [Related]
37. Poly(ADP-ribose) promotes toxicity of
Gao J; Mewborne QT; Girdhar A; Sheth U; Coyne AN; Punathil R; Kang BG; Dasovich M; Veire A; DeJesus Hernandez M; Liu S; Shi Z; Dafinca R; Fouquerel E; Talbot K; Kam TI; Zhang YJ; Dickson D; Petrucelli L; van Blitterswijk M; Guo L; Dawson TM; Dawson VL; Leung AKL; Lloyd TE; Gendron TF; Rothstein JD; Zhang K
Sci Transl Med; 2022 Sep; 14(662):eabq3215. PubMed ID: 36103513
[TBL] [Abstract][Full Text] [Related]
38. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.
Xu W; Bao P; Jiang X; Wang H; Qin M; Wang R; Wang T; Yang Y; Lorenzini I; Liao L; Sattler R; Xu J
Brain; 2019 May; 142(5):1349-1364. PubMed ID: 30938419
[TBL] [Abstract][Full Text] [Related]
39. How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.
Van't Spijker HM; Almeida S
Gene; 2023 Mar; 858():147167. PubMed ID: 36621656
[TBL] [Abstract][Full Text] [Related]
40. CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.
Guo W; Wang H; Kumar Tharkeshwar A; Couthouis J; Braems E; Masrori P; Van Schoor E; Fan Y; Ahuja K; Moisse M; Jacquemyn M; Furtado Madeiro da Costa R; Gajjar M; Balusu S; Tricot T; Fumagalli L; Hersmus N; Janky R; Impens F; Vanden Berghe P; Ho R; Thal DR; Vandenberghe R; Hegde ML; Chandran S; De Strooper B; Daelemans D; Van Damme P; Van Den Bosch L; Verfaillie C
Alzheimers Dement; 2023 Apr; 19(4):1245-1259. PubMed ID: 35993441
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]