BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 32104684)

  • 1. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
    Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
    Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
    Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
    Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
    Tang Y; Jiang M; Chen A; Qu W; Han X; Zuo J; Xu G; Song Y; Chen C; Ke X
    Mol Med Rep; 2021 Aug; 24(2):. PubMed ID: 34080032
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
    Liu Y; Qi X; Donnelly L; Elghobashi-Meinhardt N; Long T; Zhou RW; Sun Y; Wang B; Li X
    Nature; 2022 Jul; 607(7920):816-822. PubMed ID: 35831507
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
    Shah K; Panchal S; Patel B
    Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The porcupine inhibitor WNT974 provokes ectodermal lineage differentiation of human embryonic stem cells.
    Kalantary-Charvadeh A; Hosseini V; Mehdizadeh A; Nazari Soltan Ahmad S; Rahbarghazi R; Nozad Charoudeh H; Nouri M; Darabi M
    Cell Biochem Funct; 2022 Jun; 40(4):359-368. PubMed ID: 35445405
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine
    Rao DM; Shackleford MT; Bordeaux EK; Sottnik JL; Ferguson RL; Yamamoto TM; Wellberg EA; Bitler BG; Sikora MJ
    J Biol Chem; 2019 Dec; 294(52):19950-19966. PubMed ID: 31740580
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chemical Modulation of WNT Signaling in Cancer.
    Zhang LS; Lum L
    Prog Mol Biol Transl Sci; 2018 Jan; 153():245-269. PubMed ID: 29389519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway.
    Yang JM; Huang HM; Cheng JJ; Huang CL; Lee YC; Chiou CT; Huang HT; Huang NK; Yang YC
    Toxicology; 2018 Dec; 410():65-72. PubMed ID: 30205152
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.
    Kleszcz R; Szymańska A; Krajka-Kuźniak V; Baer-Dubowska W; Paluszczak J
    Cell Oncol (Dordr); 2019 Aug; 42(4):505-520. PubMed ID: 31089983
    [TBL] [Abstract][Full Text] [Related]  

  • 11. FZD6 triggers Wnt-signalling driven by WNT10B
    Cassaro A; Grillo G; Notaro M; Gliozzo J; Esposito I; Reda G; Trojani A; Valentini G; Di Camillo B; Cairoli R; Beghini A
    Hematol Oncol; 2021 Aug; 39(3):364-379. PubMed ID: 33497493
    [TBL] [Abstract][Full Text] [Related]  

  • 12. An
    Asciolla JJ; Miele MM; Hendrickson RC; Resh MD
    J Biol Chem; 2017 Aug; 292(33):13507-13513. PubMed ID: 28655768
    [TBL] [Abstract][Full Text] [Related]  

  • 13. WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
    Zimmerli D; Cecconi V; Valenta T; Hausmann G; Cantù C; Restivo G; Hafner J; Basler K; van den Broek M
    Oncogene; 2018 Jul; 37(27):3753-3762. PubMed ID: 29662191
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug.
    Bagheri M; Tabatabae Far MA; Mirzaei H; Ghasemi F
    Fundam Clin Pharmacol; 2020 Feb; 34(1):51-64. PubMed ID: 31233627
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Delivery of the Porcupine Inhibitor WNT974 in Mice.
    Zhang LS; Lum L
    Methods Mol Biol; 2016; 1481():111-7. PubMed ID: 27590157
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
    Proffitt KD; Madan B; Ke Z; Pendharkar V; Ding L; Lee MA; Hannoush RN; Virshup DM
    Cancer Res; 2013 Jan; 73(2):502-7. PubMed ID: 23188502
    [TBL] [Abstract][Full Text] [Related]  

  • 17. SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/β-catenin signaling.
    Chen L; Xie Y; Ma X; Zhang Y; Li X; Zhang F; Gao Y; Fan Y; Gu L; Wang L; Zhang X; Fu B
    Mol Carcinog; 2020 Oct; 59(10):1159-1173. PubMed ID: 32794610
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A comprehensive analysis of Wnt/β-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As
    Li YL; Jin YF; Liu XX; Li HJ
    Ren Fail; 2018 Nov; 40(1):331-339. PubMed ID: 29633893
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.
    Guimaraes PPG; Tan M; Tammela T; Wu K; Chung A; Oberli M; Wang K; Spektor R; Riley RS; Viana CTR; Jacks T; Langer R; Mitchell MJ
    J Control Release; 2018 Nov; 290():75-87. PubMed ID: 30290244
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
    Moon J; Zhou H; Zhang LS; Tan W; Liu Y; Zhang S; Morlock LK; Bao X; Palecek SP; Feng JQ; Williams NS; Amatruda JF; Olson EN; Bassel-Duby R; Lum L
    Proc Natl Acad Sci U S A; 2017 Feb; 114(7):1649-1654. PubMed ID: 28143939
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.