BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

248 related articles for article (PubMed ID: 32105735)

  • 1. β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
    Lee JH; Wolfe DM; Darji S; McBrayer MK; Colacurcio DJ; Kumar A; Stavrides P; Mohan PS; Nixon RA
    J Mol Biol; 2020 Apr; 432(8):2633-2650. PubMed ID: 32105735
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.
    Lee JH; McBrayer MK; Wolfe DM; Haslett LJ; Kumar A; Sato Y; Lie PP; Mohan P; Coffey EE; Kompella U; Mitchell CH; Lloyd-Evans E; Nixon RA
    Cell Rep; 2015 Sep; 12(9):1430-44. PubMed ID: 26299959
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca
    Fedeli C; Filadi R; Rossi A; Mammucari C; Pizzo P
    Autophagy; 2019 Dec; 15(12):2044-2062. PubMed ID: 30892128
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.
    Coen K; Flannagan RS; Baron S; Carraro-Lacroix LR; Wang D; Vermeire W; Michiels C; Munck S; Baert V; Sugita S; Wuytack F; Hiesinger PR; Grinstein S; Annaert W
    J Cell Biol; 2012 Jul; 198(1):23-35. PubMed ID: 22753898
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
    Graves AR; Curran PK; Smith CL; Mindell JA
    Nature; 2008 Jun; 453(7196):788-92. PubMed ID: 18449189
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
    Lee JH; Yu WH; Kumar A; Lee S; Mohan PS; Peterhoff CM; Wolfe DM; Martinez-Vicente M; Massey AC; Sovak G; Uchiyama Y; Westaway D; Cuervo AM; Nixon RA
    Cell; 2010 Jun; 141(7):1146-58. PubMed ID: 20541250
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.
    Majumdar A; Capetillo-Zarate E; Cruz D; Gouras GK; Maxfield FR
    Mol Biol Cell; 2011 May; 22(10):1664-76. PubMed ID: 21441306
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance.
    Leray X; Hilton JK; Nwangwu K; Becerril A; Mikusevic V; Fitzgerald G; Amin A; Weston MR; Mindell JA
    Elife; 2022 Jun; 11():. PubMed ID: 35670560
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
    Zhang X; Garbett K; Veeraraghavalu K; Wilburn B; Gilmore R; Mirnics K; Sisodia SS
    J Neurosci; 2012 Jun; 32(25):8633-48. PubMed ID: 22723704
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime.
    McBrayer M; Nixon RA
    Biochem Soc Trans; 2013 Dec; 41(6):1495-502. PubMed ID: 24256243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aerobic exercise attenuates autophagy-lysosomal flux deficits by ADRB2/β2-adrenergic receptor-mediated V-ATPase assembly factor VMA21 signaling in APP-PSEN1/PS1 mice.
    Wu JJ; Yu H; Bi SG; Wang ZX; Gong J; Mao YM; Wang FZ; Zhang YQ; Nie YJ; Chai GS
    Autophagy; 2024 May; 20(5):1015-1031. PubMed ID: 37964627
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
    Weinert S; Jabs S; Supanchart C; Schweizer M; Gimber N; Richter M; Rademann J; Stauber T; Kornak U; Jentsch TJ
    Science; 2010 Jun; 328(5984):1401-3. PubMed ID: 20430974
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A model of lysosomal pH regulation.
    Ishida Y; Nayak S; Mindell JA; Grabe M
    J Gen Physiol; 2013 Jun; 141(6):705-20. PubMed ID: 23712550
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
    Hung COY; Livesey FJ
    Cell Rep; 2018 Dec; 25(13):3647-3660.e2. PubMed ID: 30590039
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP.
    Coffey EE; Beckel JM; Laties AM; Mitchell CH
    Neuroscience; 2014 Mar; 263():111-24. PubMed ID: 24418614
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
    Neely Kayala KM; Dickinson GD; Minassian A; Walls KC; Green KN; Laferla FM
    Brain Res; 2012 Dec; 1489():8-16. PubMed ID: 23103503
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
    Mustaly-Kalimi S; Gallegos W; Marr RA; Gilman-Sachs A; Peterson DA; Sekler I; Stutzmann GE
    Proc Natl Acad Sci U S A; 2022 Dec; 119(49):e2211999119. PubMed ID: 36442130
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
    Hara-Chikuma M; Yang B; Sonawane ND; Sasaki S; Uchida S; Verkman AS
    J Biol Chem; 2005 Jan; 280(2):1241-7. PubMed ID: 15504734
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl
    Astaburuaga R; Quintanar Haro OD; Stauber T; Relógio A
    Cells; 2019 Oct; 8(10):. PubMed ID: 31623161
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.
    Jentsch TJ
    J Physiol; 2007 Feb; 578(Pt 3):633-40. PubMed ID: 17110406
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.