BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 32109059)

  • 1. Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs.
    Ward JA; Pinto-Fernandez A; Cornelissen L; Bonham S; Díaz-Sáez L; Riant O; Huber KVM; Kessler BM; Feron O; Tate EW
    J Med Chem; 2020 Apr; 63(7):3756-3762. PubMed ID: 32109059
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition.
    Mazurkiewicz M; Hillert EK; Wang X; Pellegrini P; Olofsson MH; Selvaraju K; D'Arcy P; Linder S
    Oncotarget; 2017 Mar; 8(13):21115-21127. PubMed ID: 28423502
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.
    Mofers A; Perego P; Selvaraju K; Gatti L; Gullbo J; Linder S; D'Arcy P
    PLoS One; 2019; 14(10):e0223807. PubMed ID: 31639138
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570.
    Pellegrini P; Selvaraju K; Faustini E; Mofers A; Zhang X; Ternerot J; Schubert A; Linder S; D Arcy P
    Int J Mol Sci; 2020 Jul; 21(13):. PubMed ID: 32635430
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells.
    Wang X; Mazurkiewicz M; Hillert EK; Olofsson MH; Pierrou S; Hillertz P; Gullbo J; Selvaraju K; Paulus A; Akhtar S; Bossler F; Khan AC; Linder S; D'Arcy P
    Sci Rep; 2016 Jun; 6():26979. PubMed ID: 27264969
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
    Paulus A; Akhtar S; Caulfield TR; Samuel K; Yousaf H; Bashir Y; Paulus SM; Tran D; Hudec R; Cogen D; Jiang J; Edenfield B; Novak A; Ansell SM; Witzig T; Martin P; Coleman M; Roy V; Ailawadhi S; Chitta K; Linder S; Chanan-Khan A
    Blood Cancer J; 2016 Nov; 6(11):e492. PubMed ID: 27813535
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.
    Rowinsky EK; Paner A; Berdeja JG; Paba-Prada C; Venugopal P; Porkka K; Gullbo J; Linder S; Loskog A; Richardson PG; Landgren O
    Invest New Drugs; 2020 Oct; 38(5):1448-1453. PubMed ID: 32125598
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.
    Jiang L; Sun Y; Wang J; He Q; Chen X; Lan X; Chen J; Dou QP; Shi X; Liu J
    J Exp Clin Cancer Res; 2019 Nov; 38(1):453. PubMed ID: 31694672
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
    Chitta K; Paulus A; Akhtar S; Blake MK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
    Br J Haematol; 2015 May; 169(3):377-90. PubMed ID: 25691154
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dienone Compounds: Targets and Pharmacological Responses.
    Bazzaro M; Linder S
    J Med Chem; 2020 Dec; 63(24):15075-15093. PubMed ID: 33146523
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System.
    Selvaraju K; Lotfi K; Gubat J; Miquel M; Nilsson A; Hill J; Jensen LD; Linder S; D'Arcy P
    Biomolecules; 2021 Sep; 11(9):. PubMed ID: 34572552
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes.
    Issaenko OA; Amerik AY
    Cell Cycle; 2012 May; 11(9):1804-17. PubMed ID: 22510564
    [TBL] [Abstract][Full Text] [Related]  

  • 13. USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.
    Vogel RI; Pulver T; Heilmann W; Mooneyham A; Mullany S; Zhao X; Shahi M; Richter J; Klein M; Chen L; Ding R; Konecny G; Kommoss S; Winterhoff B; Ghebre R; Bazzaro M
    Oncotarget; 2016 May; 7(21):30962-76. PubMed ID: 27121063
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.
    Wang X; Stafford W; Mazurkiewicz M; Fryknäs M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arnér ES; D'Arcy P; Linder S
    Mol Pharmacol; 2014 Jun; 85(6):932-45. PubMed ID: 24714215
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells.
    Ding Y; Chen X; Wang B; Yu B; Ge J
    Eur J Pharmacol; 2018 Apr; 825():10-18. PubMed ID: 29454609
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors.
    Schauer NJ; Magin RS; Liu X; Doherty LM; Buhrlage SJ
    J Med Chem; 2020 Mar; 63(6):2731-2750. PubMed ID: 31682427
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells.
    Schmidt M; Altdörfer V; Schnitte S; Fuchs AR; Kropp KN; Maurer S; Müller MR; Salih HR; Rittig SM; Grünebach F; Dörfel D
    Neoplasia; 2019 Jul; 21(7):653-664. PubMed ID: 31132676
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cell-Permeable Activity-Based Ubiquitin Probes Enable Intracellular Profiling of Human Deubiquitinases.
    Gui W; Ott CA; Yang K; Chung JS; Shen S; Zhuang Z
    J Am Chem Soc; 2018 Oct; 140(39):12424-12433. PubMed ID: 30240200
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.
    Zhang X; Pellegrini P; Saei AA; Hillert EK; Mazurkiewicz M; Olofsson MH; Zubarev RA; D'Arcy P; Linder S
    Biochem Pharmacol; 2018 Oct; 156():291-301. PubMed ID: 30149015
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.
    Long MJC; Lawson AP; Baggio R; Qian Y; Rozhansky L; Fasci D; El Oualid F; Weerapana E; Hedstrom L
    Bioorg Med Chem Lett; 2019 Jan; 29(2):204-211. PubMed ID: 30528168
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.