BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

307 related articles for article (PubMed ID: 32130004)

  • 1. Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
    Hansen JD; Correa M; Nagy MA; Alexander M; Plantevin V; Grant V; Whitefield B; Huang D; Kercher T; Harris R; Narla RK; Leisten J; Tang Y; Moghaddam M; Ebinger K; Piccotti J; Havens CG; Cathers B; Carmichael J; Daniel T; Vessey R; Hamann LG; Leftheris K; Mendy D; Baculi F; LeBrun LA; Khambatta G; Lopez-Girona A
    J Med Chem; 2020 Jul; 63(13):6648-6676. PubMed ID: 32130004
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN.
    Bjorklund CC; Kang J; Amatangelo M; Polonskaia A; Katz M; Chiu H; Couto S; Wang M; Ren Y; Ortiz M; Towfic F; Flynt JE; Pierceall W; Thakurta A
    Leukemia; 2020 Apr; 34(4):1197-1201. PubMed ID: 31719682
    [No Abstract]   [Full Text] [Related]  

  • 3. Old and new generation immunomodulatory drugs in multiple myeloma.
    Derudas D; Capraro F; Martinelli G; Cerchione C
    Panminerva Med; 2020 Dec; 62(4):207-219. PubMed ID: 32955182
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance.
    Zou J; Jones RJ; Wang H; Kuiatse I; Shirazi F; Manasanch EE; Lee HC; Sullivan R; Fung L; Richard N; Erdman P; Torres E; Hecht D; Lam I; McElwee B; Chourasia AH; Chan KWH; Mercurio F; Stirling DI; Orlowski RZ
    J Mol Med (Berl); 2020 Aug; 98(8):1161-1173. PubMed ID: 32632752
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs.
    Lindner S; Steinebach C; Kehm H; Mangold M; Gütschow M; Krönke J
    J Vis Exp; 2019 May; (147):. PubMed ID: 31157769
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.
    Gooding S; Ansari-Pour N; Towfic F; Ortiz Estévez M; Chamberlain PP; Tsai KT; Flynt E; Hirst M; Rozelle D; Dhiman P; Neri P; Ramasamy K; Bahlis N; Vyas P; Thakurta A
    Blood; 2021 Jan; 137(2):232-237. PubMed ID: 33443552
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
    Matyskiela ME; Zhang W; Man HW; Muller G; Khambatta G; Baculi F; Hickman M; LeBrun L; Pagarigan B; Carmel G; Lu CC; Lu G; Riley M; Satoh Y; Schafer P; Daniel TO; Carmichael J; Cathers BE; Chamberlain PP
    J Med Chem; 2018 Jan; 61(2):535-542. PubMed ID: 28425720
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
    Tateno S; Iida M; Fujii S; Suwa T; Katayama M; Tokuyama H; Yamamoto J; Ito T; Sakamoto S; Handa H; Yamaguchi Y
    Sci Rep; 2020 Mar; 10(1):4012. PubMed ID: 32132601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
    Hansen JD; Correa M; Alexander M; Nagy M; Huang D; Sapienza J; Lu G; LeBrun LA; Cathers BE; Zhang W; Tang Y; Ammirante M; Narla RK; Piccotti JR; Pourdehnad M; Lopez-Girona A
    J Med Chem; 2021 Feb; 64(4):1835-1843. PubMed ID: 33591756
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mezigdomide-A Novel Cereblon E3 Ligase Modulator under Investigation in Relapsed/Refractory Multiple Myeloma.
    Hartley-Brown MA; Mo CC; Nadeem O; Midha S; Laubach JP; Richardson PG
    Cancers (Basel); 2024 Mar; 16(6):. PubMed ID: 38539501
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors.
    Abruzzese MP; Bilotta MT; Fionda C; Zingoni A; Soriani A; Petrucci MT; Ricciardi MR; Molfetta R; Paolini R; Santoni A; Cippitelli M
    Cell Death Dis; 2019 Apr; 10(4):324. PubMed ID: 30975979
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cereblon-Targeting Ligase Degraders in Myeloma: Mechanisms of Action and Resistance.
    Lee H; Neri P; Bahlis NJ
    Hematol Oncol Clin North Am; 2024 Apr; 38(2):305-319. PubMed ID: 38302306
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
    Surka C; Jin L; Mbong N; Lu CC; Jang IS; Rychak E; Mendy D; Clayton T; Tindall E; Hsu C; Fontanillo C; Tran E; Contreras A; Ng SWK; Matyskiela M; Wang K; Chamberlain P; Cathers B; Carmichael J; Hansen J; Wang JCY; Minden MD; Fan J; Pierce DW; Pourdehnad M; Rolfe M; Lopez-Girona A; Dick JE; Lu G
    Blood; 2021 Feb; 137(5):661-677. PubMed ID: 33197925
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity.
    Liu J; Song T; Zhou W; Xing L; Wang S; Ho M; Peng Z; Tai YT; Hideshima T; Anderson KC; Cang Y
    Leukemia; 2019 Jan; 33(1):171-180. PubMed ID: 30026574
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease.
    Richardson PG; Mateos MV; Vangsted AJ; Ramasamy K; Abildgaard N; Ho PJ; Quach H; Bahlis NJ
    Expert Rev Proteomics; 2022; 19(4-6):235-246. PubMed ID: 36342226
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Profiling CELMoD-Mediated Degradation of Cereblon Neosubstrates.
    Thompson JW; Clayton T; Khambatta G; Bateman LA; Carroll CW; Chamberlain PP; Matyskiela ME
    Methods Mol Biol; 2021; 2365():283-300. PubMed ID: 34432250
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma.
    Gooding S; Ansari-Pour N; Kazeroun M; Karagoz K; Polonskaia A; Salazar M; Fitzsimons E; Sirinukunwattana K; Chavda S; Ortiz Estevez M; Towfic F; Flynt E; Pierceall W; Royston D; Yong K; Ramasamy K; Vyas P; Thakurta A
    Blood; 2022 Oct; 140(16):1816-1821. PubMed ID: 35853156
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function.
    Liu Y; Huang X; He X; Zhou Y; Jiang X; Chen-Kiang S; Jaffrey SR; Xu G
    FASEB J; 2015 Dec; 29(12):4829-39. PubMed ID: 26231201
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rapid Progress in the Use of Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma.
    Charliński G; Vesole DH; Jurczyszyn A
    Cancers (Basel); 2021 Sep; 13(18):. PubMed ID: 34572892
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacodynamic changes in tumor and immune cells drive iberdomide's clinical mechanisms of activity in relapsed and refractory multiple myeloma.
    Amatangelo M; Flynt E; Stong N; Ray P; Van Oekelen O; Wang M; Ortiz M; Maciag P; Peluso T; Parekh S; van de Donk NWCJ; Lonial S; Thakurta A
    Cell Rep Med; 2024 Jun; 5(6):101571. PubMed ID: 38776914
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.