212 related articles for article (PubMed ID: 32163418)
1. Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.
Cianni L; Lemke C; Gilberg E; Feldmann C; Rosini F; Rocho FDR; Ribeiro JFR; Tezuka DY; Lopes CD; de Albuquerque S; Bajorath J; Laufer S; Leitão A; Gütschow M; Montanari CA
PLoS Negl Trop Dis; 2020 Mar; 14(3):e0007755. PubMed ID: 32163418
[TBL] [Abstract][Full Text] [Related]
2. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
Ribeiro JFR; Cianni L; Li C; Warwick TG; de Vita D; Rosini F; Dos Reis Rocho F; Martins FCP; Kenny PW; Lameira J; Leitão A; Emsley J; Montanari CA
Bioorg Med Chem; 2020 Nov; 28(22):115743. PubMed ID: 33038787
[TBL] [Abstract][Full Text] [Related]
3. Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.
Burtoloso AC; de Albuquerque S; Furber M; Gomes JC; Gonçalez C; Kenny PW; Leitão A; Montanari CA; Quilles JC; Ribeiro JF; Rocha JR
PLoS Negl Trop Dis; 2017 Feb; 11(2):e0005343. PubMed ID: 28222138
[TBL] [Abstract][Full Text] [Related]
4. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.
Avelar LA; Camilo CD; de Albuquerque S; Fernandes WB; Gonçalez C; Kenny PW; Leitão A; McKerrow JH; Montanari CA; Orozco EV; Ribeiro JF; Rocha JR; Rosini F; Saidel ME
PLoS Negl Trop Dis; 2015; 9(7):e0003916. PubMed ID: 26173110
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.
Chen YT; Lira R; Hansell E; McKerrow JH; Roush WR
Bioorg Med Chem Lett; 2008 Nov; 18(22):5860-3. PubMed ID: 18585034
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
7. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles.
Dos Santos AM; Cianni L; De Vita D; Rosini F; Leitão A; Laughton CA; Lameira J; Montanari CA
Phys Chem Chem Phys; 2018 Sep; 20(37):24317-24328. PubMed ID: 30211406
[TBL] [Abstract][Full Text] [Related]
8. α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.
Steert K; Berg M; Mottram JC; Westrop GD; Coombs GH; Cos P; Maes L; Joossens J; Van der Veken P; Haemers A; Augustyns K
ChemMedChem; 2010 Oct; 5(10):1734-48. PubMed ID: 20799311
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
Du X; Guo C; Hansell E; Doyle PS; Caffrey CR; Holler TP; McKerrow JH; Cohen FE
J Med Chem; 2002 Jun; 45(13):2695-707. PubMed ID: 12061873
[TBL] [Abstract][Full Text] [Related]
10. Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.
Di Chio C; Previti S; Amendola G; Ravichandran R; Wagner A; Cosconati S; Hellmich UA; Schirmeister T; Zappalà M; Ettari R
Eur J Med Chem; 2022 Jun; 236():114328. PubMed ID: 35385806
[TBL] [Abstract][Full Text] [Related]
11. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.
Scheidt KA; Roush WR; McKerrow JH; Selzer PM; Hansell E; Rosenthal PJ
Bioorg Med Chem; 1998 Dec; 6(12):2477-94. PubMed ID: 9925304
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach.
de Souza ML; de Oliveira Rezende Junior C; Ferreira RS; Espinoza Chávez RM; Ferreira LLG; Slafer BW; Magalhães LG; Krogh R; Oliva G; Cruz FC; Dias LC; Andricopulo AD
J Chem Inf Model; 2020 Feb; 60(2):1028-1041. PubMed ID: 31765144
[TBL] [Abstract][Full Text] [Related]
13. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Chenna BC; Li L; Mellott DM; Zhai X; Siqueira-Neto JL; Calvet Alvarez C; Bernatchez JA; Desormeaux E; Alvarez Hernandez E; Gomez J; McKerrow JH; Cruz-Reyes J; Meek TD
J Med Chem; 2020 Mar; 63(6):3298-3316. PubMed ID: 32125159
[TBL] [Abstract][Full Text] [Related]
14. Discovery of Novel Inhibitors of Cruzain Cysteine Protease of
Prates JLB; Lopes JR; Chin CM; Ferreira EI; Dos Santos JL; Scarim CB
Curr Med Chem; 2024; 31(16):2285-2308. PubMed ID: 37888814
[TBL] [Abstract][Full Text] [Related]
15. Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.
Schröder J; Noack S; Marhöfer RJ; Mottram JC; Coombs GH; Selzer PM
PLoS One; 2013; 8(10):e77460. PubMed ID: 24146999
[TBL] [Abstract][Full Text] [Related]
16. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors.
Cianni L; Sartori G; Rosini F; De Vita D; Pires G; Lopes BR; Leitão A; Burtoloso ACB; Montanari CA
Bioorg Chem; 2018 Sep; 79():285-292. PubMed ID: 29783099
[TBL] [Abstract][Full Text] [Related]
17. Reversible cysteine protease inhibitors show promise for a Chagas disease cure.
Ndao M; Beaulieu C; Black WC; Isabel E; Vasquez-Camargo F; Nath-Chowdhury M; Massé F; Mellon C; Methot N; Nicoll-Griffith DA
Antimicrob Agents Chemother; 2014; 58(2):1167-78. PubMed ID: 24323474
[TBL] [Abstract][Full Text] [Related]
18. Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.
Trossini GH; Malvezzi A; T-do Amaral A; Rangel-Yagui CO; Izidoro MA; Cezari MH; Juliano L; Chin CM; Menezes CM; Ferreira EI
J Enzyme Inhib Med Chem; 2010 Feb; 25(1):62-7. PubMed ID: 20030510
[TBL] [Abstract][Full Text] [Related]
19. Novel cruzain inhibitors for the treatment of Chagas' disease.
Rogers KE; Keränen H; Durrant JD; Ratnam J; Doak A; Arkin MR; McCammon JA
Chem Biol Drug Des; 2012 Sep; 80(3):398-405. PubMed ID: 22613098
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds.
Fonseca Lameiro RD; Shamim A; Rosini F; Cendron R; Jatai Batista PH; Montanari CA
Future Med Chem; 2021 Jan; 13(1):25-43. PubMed ID: 33289603
[No Abstract] [Full Text] [Related]
[Next] [New Search]
