136 related articles for article (PubMed ID: 32171616)
1. Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease.
Huang XF; Dong YH; Wang JH; Ke HM; Song GQ; Xu DF
Bioorg Med Chem Lett; 2020 May; 30(9):127097. PubMed ID: 32171616
[TBL] [Abstract][Full Text] [Related]
2. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.
Mao F; Wang H; Ni W; Zheng X; Wang M; Bao K; Ling D; Li X; Xu Y; Zhang H; Li J
ACS Chem Neurosci; 2018 Feb; 9(2):328-345. PubMed ID: 29068218
[TBL] [Abstract][Full Text] [Related]
3. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).
Ni W; Wang H; Li X; Zheng X; Wang M; Zhang J; Gong Q; Ling D; Mao F; Zhang H; Li J
ACS Chem Neurosci; 2018 Jul; 9(7):1625-1636. PubMed ID: 29616790
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Rabal O; Sánchez-Arias JA; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; García-Barroso C; Ugarte A; Estella-Hermoso de Mendoza A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
Eur J Med Chem; 2018 Apr; 150():506-524. PubMed ID: 29549837
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and evaluation of N
Pobsuk N; Paracha TU; Chaichamnong N; Salaloy N; Suphakun P; Hannongbua S; Choowongkomon K; Pekthong D; Chootip K; Ingkaninan K; Gleeson MP
Bioorg Med Chem Lett; 2019 Jan; 29(2):267-270. PubMed ID: 30509781
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Reddy GL; Dar MI; Hudwekar AD; Mahajan P; Nargotra A; Baba AM; Nandi U; Wazir P; Singh G; Vishwakarma RA; Syed SH; Sawant SD
Bioorg Chem; 2019 Aug; 89():103022. PubMed ID: 31181491
[TBL] [Abstract][Full Text] [Related]
7. 8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.
Sakamoto T; Koga Y; Hikota M; Matsuki K; Mochida H; Kikkawa K; Fujishige K; Kotera J; Omori K; Morimoto H; Yamada K
Bioorg Med Chem Lett; 2015 Apr; 25(7):1431-5. PubMed ID: 25754491
[TBL] [Abstract][Full Text] [Related]
8. Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Rabal O; Sánchez-Arias JA; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; García-Barroso C; Ugarte A; Estella-Hermoso de Mendoza A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
J Med Chem; 2016 Oct; 59(19):8967-9004. PubMed ID: 27606546
[TBL] [Abstract][Full Text] [Related]
9. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.
Rabal O; Sánchez-Arias JA; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; García-Barroso C; Ugarte A; Estella-Hermoso de Mendoza A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
ACS Chem Neurosci; 2019 Mar; 10(3):1765-1782. PubMed ID: 30525452
[TBL] [Abstract][Full Text] [Related]
10. [Effect of rutaecarpine on Alzheimer's disease-like cognitive impairments induced by high glucose in rats].
Chen JG; Wu YG; Li X
Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2019 Feb; 35(2):178-182. PubMed ID: 31250613
[TBL] [Abstract][Full Text] [Related]
11. Pharmacophore based virtual screening, molecular docking and biological evaluation to identify novel PDE5 inhibitors with vasodilatory activity.
Mittal A; Paliwal S; Sharma M; Singh A; Sharma S; Yadav D
Bioorg Med Chem Lett; 2014 Jul; 24(14):3137-41. PubMed ID: 24856068
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.
Zhang T; Lai Z; Yuan S; Huang YY; Dong G; Sheng C; Ke H; Luo HB
J Med Chem; 2020 Sep; 63(17):9828-9837. PubMed ID: 32794708
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Wang B; Mai YC; Li Y; Hou JQ; Huang SL; Ou TM; Tan JH; An LK; Li D; Gu LQ; Huang ZS
Eur J Med Chem; 2010 Apr; 45(4):1415-23. PubMed ID: 20079560
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of pyrazolo[3,4-d]pyrimidinone derivatives: Discovery of selective phosphodiesterase-5 inhibitors.
Shaaban MA; Elshaier YAMM; Hammad AH; Farag NA; Hassan Haredy H; AbdEl-Ghany AA; Mohamed KO
Bioorg Med Chem Lett; 2020 Aug; 30(16):127337. PubMed ID: 32631538
[TBL] [Abstract][Full Text] [Related]
15. Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Abdel-Halim M; Tinsley H; Keeton AB; Weam M; Atta NH; Hammam MA; Hefnawy A; Hartmann RW; Engel M; Piazza GA; Abadi AH
Bioorg Chem; 2020 Nov; 104():104322. PubMed ID: 33142429
[TBL] [Abstract][Full Text] [Related]
16. Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5.
Sawant SD; Lakshma Reddy G; Dar MI; Srinivas M; Gupta G; Sahu PK; Mahajan P; Nargotra A; Singh S; Sharma SC; Tikoo M; Singh G; Vishwakarma RA; Syed SH
Bioorg Med Chem; 2015 May; 23(9):2121-8. PubMed ID: 25801159
[TBL] [Abstract][Full Text] [Related]
17. Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.
Chau Y; Li FS; Levsh O; Weng JK
PLoS One; 2019; 14(9):e0222803. PubMed ID: 31539416
[TBL] [Abstract][Full Text] [Related]
18. Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors.
Zheng H; Li L; Sun B; Gao Y; Song W; Zhao X; Gao Y; Xie Z; Zhang N; Ji J; Yuan H; Lou H
Eur J Med Chem; 2018 Apr; 150():30-38. PubMed ID: 29505934
[TBL] [Abstract][Full Text] [Related]
19. 2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
Li Z; Wang B; Hou JQ; Huang SL; Ou TM; Tan JH; An LK; Li D; Gu LQ; Huang ZS
J Enzyme Inhib Med Chem; 2013 Jun; 28(3):583-92. PubMed ID: 22380775
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes.
Liu J; Maisonial-Besset A; Wenzel B; Canitrot D; Baufond A; Chezal JM; Brust P; Moreau E
Eur J Med Chem; 2017 Aug; 136():548-560. PubMed ID: 28544981
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
