BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 32235053)

  • 1. The phasor FLIM method reveals a link between a change in energy metabolism and mHtt protein spread in healthy Mammalian cells when co-cultured with Huntington diseased cells.
    Sameni S; Zhang R; Digman MA
    Methods Appl Fluoresc; 2021 Jan; 9(1):. PubMed ID: 32235053
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease.
    Sameni S; Syed A; Marsh JL; Digman MA
    Sci Rep; 2016 Oct; 6():34755. PubMed ID: 27713486
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
    Chongtham A; Bornemann DJ; Barbaro BA; Lukacsovich T; Agrawal N; Syed A; Worthge S; Purcell J; Burke J; Chin TM; Marsh JL
    Hum Mol Genet; 2020 Mar; 29(4):674-688. PubMed ID: 31943010
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.
    Lin L; Jin Z; Tan H; Xu Q; Peng T; Li H
    Brain Res; 2016 Jul; 1643():103-12. PubMed ID: 27107943
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using
    Bertoglio D; Weiss AR; Liguore W; Martin LD; Hobbs T; Templon J; Srinivasan S; Dominguez C; Munoz-Sanjuan I; Khetarpal V; Verhaeghe J; Staelens S; Link J; Liu L; Bard JA; McBride JL
    J Nucl Med; 2023 Oct; 64(10):1581-1587. PubMed ID: 37591545
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
    Caron NS; Banos R; Yanick C; Aly AE; Byrne LM; Smith ED; Xie Y; Smith SEP; Potluri N; Findlay Black H; Casal L; Ko S; Cheung D; Kim H; Seong IS; Wild EJ; Song JJ; Hayden MR; Southwell AL
    J Neurosci; 2021 Jan; 41(4):780-796. PubMed ID: 33310753
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells.
    Wilbertz JH; Frappier J; Muller S; Gratzer S; Englaro W; Stanek LM; Calamini B
    SLAS Discov; 2022 Jun; 27(4):219-228. PubMed ID: 35058188
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.
    Galaz-Montoya JG; Shahmoradian SH; Shen K; Frydman J; Chiu W
    Commun Biol; 2021 Jul; 4(1):849. PubMed ID: 34239038
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.
    Chen M; Wolynes PG
    Proc Natl Acad Sci U S A; 2017 Apr; 114(17):4406-4411. PubMed ID: 28400517
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Proteostasis of Huntingtin in Health and Disease.
    Koyuncu S; Fatima A; Gutierrez-Garcia R; Vilchez D
    Int J Mol Sci; 2017 Jul; 18(7):. PubMed ID: 28753941
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.
    van Hagen M; Piebes DGE; de Leeuw WC; Vuist IM; van Roon-Mom WMC; Moerland PD; Verschure PJ
    BMC Genomics; 2017 May; 18(1):373. PubMed ID: 28499347
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
    Wang B; Zeng L; Merillat SA; Fischer S; Ochaba J; Thompson LM; Barmada SJ; Scaglione KM; Paulson HL
    Neurobiol Dis; 2018 Jan; 109(Pt A):127-136. PubMed ID: 28986324
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
    Huang B; Guo Q; Niedermeier ML; Cheng J; Engler T; Maurer M; Pautsch A; Baumeister W; Stengel F; Kochanek S; Fernández-Busnadiego R
    Structure; 2021 Aug; 29(8):804-809.e5. PubMed ID: 33909994
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects.
    Hakim-Eshed V; Boulos A; Cohen-Rosenzweig C; Yu-Taeger L; Ziv T; Kwon YT; Riess O; Phuc Nguyen HH; Ziv NE; Ciechanover A
    Proc Natl Acad Sci U S A; 2020 Aug; 117(31):18661-18669. PubMed ID: 32675242
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease.
    Wetzel R
    Acc Chem Res; 2020 Oct; 53(10):2347-2357. PubMed ID: 32975927
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
    Zheng S; Ghitani N; Blackburn JS; Liu JP; Zeitlin SO
    Mol Brain; 2012 Aug; 5():28. PubMed ID: 22892315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
    Herrmann F; Hessmann M; Schaertl S; Berg-Rosseburg K; Brown CJ; Bursow G; Chiki A; Ebneth A; Gehrmann M; Hoeschen N; Hotze M; Jahn S; Johnson PD; Khetarpal V; Kiselyov A; Kottig K; Ladewig S; Lashuel H; Letschert S; Mills MR; Petersen K; Prime ME; Scheich C; Schmiedel G; Wityak J; Liu L; Dominguez C; Muñoz-Sanjuán I; Bard JA
    Sci Rep; 2021 Sep; 11(1):17977. PubMed ID: 34504195
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
    Liu X; Wang CE; Hong Y; Zhao T; Wang G; Gaertig MA; Sun M; Li S; Li XJ
    PLoS Genet; 2016 May; 12(5):e1006083. PubMed ID: 27203582
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys.
    Cho IK; Yang B; Forest C; Qian L; Chan AWS
    PLoS One; 2019; 14(3):e0214156. PubMed ID: 30897183
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
    Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
    J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.