115 related articles for article (PubMed ID: 32259333)
1. Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product.
Lence E; Maneiro M; Sanz-Gaitero M; van Raaij MJ; Thompson P; Hawkins AR; González-Bello C
Chemistry; 2020 Jun; 26(36):8035-8044. PubMed ID: 32259333
[TBL] [Abstract][Full Text] [Related]
2. Irreversible covalent modification of type I dehydroquinase with a stable Schiff base.
Tizón L; Maneiro M; Peón A; Otero JM; Lence E; Poza S; van Raaij MJ; Thompson P; Hawkins AR; González-Bello C
Org Biomol Chem; 2015 Jan; 13(3):706-16. PubMed ID: 25370445
[TBL] [Abstract][Full Text] [Related]
3. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.
González-Bello C; Tizón L; Lence E; Otero JM; van Raaij MJ; Martinez-Guitian M; Beceiro A; Thompson P; Hawkins AR
J Am Chem Soc; 2015 Jul; 137(29):9333-43. PubMed ID: 26148116
[TBL] [Abstract][Full Text] [Related]
4. Specific chemical modification of bacterial type I dehydroquinase--opportunities for drug discovery.
González-Bello C
Future Med Chem; 2015; 7(17):2371-83. PubMed ID: 26599605
[TBL] [Abstract][Full Text] [Related]
5. Insights into substrate binding and catalysis in bacterial type I dehydroquinase.
Maneiro M; Peón A; Lence E; Otero JM; Van Raaij MJ; Thompson P; Hawkins AR; González-Bello C
Biochem J; 2014 Sep; 462(3):415-24. PubMed ID: 24957267
[TBL] [Abstract][Full Text] [Related]
6. Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme-A molecular insight.
Rodríguez Á; Maneiro M; Lence E; Otero JM; van Raaij MJ; Thompson P; Hawkins AR; González-Bello C
Front Mol Biosci; 2023; 10():1111598. PubMed ID: 36762206
[TBL] [Abstract][Full Text] [Related]
7. Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis.
Zou Y; Garcia-Borràs M; Tang MC; Hirayama Y; Li DH; Li L; Watanabe K; Houk KN; Tang Y
Nat Chem Biol; 2017 Mar; 13(3):325-332. PubMed ID: 28114276
[TBL] [Abstract][Full Text] [Related]
8. Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.
Peón A; Robles A; Blanco B; Convertino M; Thompson P; Hawkins AR; Caflisch A; González-Bello C
ChemMedChem; 2017 Sep; 12(18):1512-1524. PubMed ID: 28791799
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.
Gonzalez-Bello C
Curr Top Med Chem; 2016; 16(9):960-77. PubMed ID: 26303426
[TBL] [Abstract][Full Text] [Related]
10. Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.
Howard NI; Dias MV; Peyrot F; Chen L; Schmidt MF; Blundell TL; Abell C
ChemMedChem; 2015 Jan; 10(1):116-33. PubMed ID: 25234229
[TBL] [Abstract][Full Text] [Related]
11. Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.
Blanco B; Sedes A; Peón A; Otero JM; van Raaij MJ; Thompson P; Hawkins AR; González-Bello C
J Med Chem; 2014 Apr; 57(8):3494-510. PubMed ID: 24689821
[TBL] [Abstract][Full Text] [Related]
12. Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.
Coderch C; Lence E; Peón A; Lamb H; Hawkins AR; Gago F; González-Bello C
Biochem J; 2014 Mar; 458(3):547-57. PubMed ID: 24392963
[TBL] [Abstract][Full Text] [Related]
13. The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Gourley DG; Shrive AK; Polikarpov I; Krell T; Coggins JR; Hawkins AR; Isaacs NW; Sawyer L
Nat Struct Biol; 1999 Jun; 6(6):521-5. PubMed ID: 10360352
[TBL] [Abstract][Full Text] [Related]
14. Cobalamin-dependent dehydratases and a deaminase: radical catalysis and reactivating chaperones.
Toraya T
Arch Biochem Biophys; 2014 Feb; 544():40-57. PubMed ID: 24269950
[TBL] [Abstract][Full Text] [Related]
15. Structural insights into human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations.
Saenz-Méndez P; Katz A; Pérez-Kempner ML; Ventura ON; Vázquez M
Proteins; 2017 Apr; 85(4):720-730. PubMed ID: 28120429
[TBL] [Abstract][Full Text] [Related]
16. Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids.
Peón A; Otero JM; Tizón L; Prazeres VF; Llamas-Saiz AL; Fox GC; van Raaij MJ; Lamb H; Hawkins AR; Gago F; Castedo L; González-Bello C
ChemMedChem; 2010 Oct; 5(10):1726-33. PubMed ID: 20815012
[TBL] [Abstract][Full Text] [Related]
17. Mechanism-based inactivation of cytochromes by furan epoxide: unraveling the molecular mechanism.
Taxak N; Kalra S; Bharatam PV
Inorg Chem; 2013 Dec; 52(23):13496-508. PubMed ID: 24236636
[TBL] [Abstract][Full Text] [Related]
18. Dihydrodipicolinate Synthase: Structure, Dynamics, Function, and Evolution.
Grant Pearce F; Hudson AO; Loomes K; Dobson RCJ
Subcell Biochem; 2017; 83():271-289. PubMed ID: 28271480
[TBL] [Abstract][Full Text] [Related]
19. Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
Yew WS; Fedorov AA; Fedorov EV; Almo SC; Gerlt JA
Biochemistry; 2007 Aug; 46(33):9564-77. PubMed ID: 17649980
[TBL] [Abstract][Full Text] [Related]
20. A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
Tizón L; Otero JM; Prazeres VF; Llamas-Saiz AL; Fox GC; van Raaij MJ; Lamb H; Hawkins AR; Ainsa JA; Castedo L; González-Bello C
J Med Chem; 2011 Sep; 54(17):6063-84. PubMed ID: 21780742
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]