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2. Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. Nóbrega C; Nascimento-Ferreira I; Onofre I; Albuquerque D; Hirai H; Déglon N; de Almeida LP PLoS One; 2013; 8(1):e52396. PubMed ID: 23349684 [TBL] [Abstract][Full Text] [Related]
3. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Nascimento-Ferreira I; Nóbrega C; Vasconcelos-Ferreira A; Onofre I; Albuquerque D; Aveleira C; Hirai H; Déglon N; Pereira de Almeida L Brain; 2013 Jul; 136(Pt 7):2173-88. PubMed ID: 23801739 [TBL] [Abstract][Full Text] [Related]
4. Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease. Duarte-Neves J; Gonçalves N; Cunha-Santos J; Simões AT; den Dunnen WF; Hirai H; Kügler S; Cavadas C; Pereira de Almeida L Hum Mol Genet; 2015 Oct; 24(19):5451-63. PubMed ID: 26220979 [TBL] [Abstract][Full Text] [Related]
5. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L Ann Neurol; 2017 Mar; 81(3):407-418. PubMed ID: 28032667 [TBL] [Abstract][Full Text] [Related]
6. Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease. Duarte-Neves J; Cavadas C; Pereira de Almeida L Sci Rep; 2021 Feb; 11(1):3345. PubMed ID: 33558582 [TBL] [Abstract][Full Text] [Related]
7. Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy. Watchon M; Yuan KC; Mackovski N; Svahn AJ; Cole NJ; Goldsbury C; Rinkwitz S; Becker TS; Nicholson GA; Laird AS J Neurosci; 2017 Aug; 37(32):7782-7794. PubMed ID: 28687604 [TBL] [Abstract][Full Text] [Related]
8. Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology. Nóbrega C; Nascimento-Ferreira I; Onofre I; Albuquerque D; Conceição M; Déglon N; de Almeida LP Cerebellum; 2013 Aug; 12(4):441-55. PubMed ID: 23242710 [TBL] [Abstract][Full Text] [Related]
9. The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease. Vasconcelos-Ferreira A; Carmo-Silva S; Codêsso JM; Silva P; Martinez ARM; França MC; Nóbrega C; Pereira de Almeida L Neuropathol Appl Neurobiol; 2022 Feb; 48(1):e12763. PubMed ID: 34432315 [TBL] [Abstract][Full Text] [Related]
10. RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3. Nóbrega C; Codêsso JM; Mendonça L; Pereira de Almeida L Hum Gene Ther; 2019 Jul; 30(7):841-854. PubMed ID: 30760052 [TBL] [Abstract][Full Text] [Related]
11. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S; Régulier E; Nascimento-Ferreira I; Hassig R; Dufour N; Koeppen A; Carvalho AL; Simões S; de Lima MC; Brouillet E; Gould VC; Déglon N; de Almeida LP Hum Mol Genet; 2008 Jul; 17(14):2071-83. PubMed ID: 18385100 [TBL] [Abstract][Full Text] [Related]
12. Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease. Lin GY; Ma CY; Kuo LC; Hsieh BY; Wang H; Liu CS; Hsieh M Metab Brain Dis; 2022 Aug; 37(6):2103-2120. PubMed ID: 35488942 [TBL] [Abstract][Full Text] [Related]
13. The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples. Duarte Lobo D; Nobre RJ; Oliveira Miranda C; Pereira D; Castelhano J; Sereno J; Koeppen A; Castelo-Branco M; Pereira de Almeida L Acta Neuropathol Commun; 2020 Aug; 8(1):152. PubMed ID: 32867861 [TBL] [Abstract][Full Text] [Related]
14. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease. Simões AT; Gonçalves N; Nobre RJ; Duarte CB; Pereira de Almeida L Hum Mol Genet; 2014 Sep; 23(18):4932-44. PubMed ID: 24817574 [TBL] [Abstract][Full Text] [Related]
15. Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice. Gamage HKAH; Robinson KJ; Luu L; Paulsen IT; Laird AS Neurobiol Dis; 2023 Apr; 179():106051. PubMed ID: 36822548 [TBL] [Abstract][Full Text] [Related]
16. Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3. Simões AT; Carmona V; Duarte-Neves J; Cunha-Santos J; Pereira de Almeida L Neuropathol Appl Neurobiol; 2022 Feb; 48(1):e12748. PubMed ID: 34273111 [TBL] [Abstract][Full Text] [Related]
17. Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia. Nóbrega C; Mendonça L; Marcelo A; Lamazière A; Tomé S; Despres G; Matos CA; Mechmet F; Langui D; den Dunnen W; de Almeida LP; Cartier N; Alves S Acta Neuropathol; 2019 Nov; 138(5):837-858. PubMed ID: 31197505 [TBL] [Abstract][Full Text] [Related]
18. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I; Santos-Ferreira T; Sousa-Ferreira L; Auregan G; Onofre I; Alves S; Dufour N; Colomer Gould VF; Koeppen A; Déglon N; Pereira de Almeida L Brain; 2011 May; 134(Pt 5):1400-15. PubMed ID: 21478185 [TBL] [Abstract][Full Text] [Related]
19. Mouse models of Machado-Joseph disease and other polyglutamine spinocerebellar ataxias. Colomer Gould VF NeuroRx; 2005 Jul; 2(3):480-3. PubMed ID: 16389311 [TBL] [Abstract][Full Text] [Related]
20. Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease. Silva-Fernandes A; Duarte-Silva S; Neves-Carvalho A; Amorim M; Soares-Cunha C; Oliveira P; Thirstrup K; Teixeira-Castro A; Maciel P Neurotherapeutics; 2014 Apr; 11(2):433-49. PubMed ID: 24477711 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]