109 related articles for article (PubMed ID: 32297742)
1. Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
Shao H; Mohamed H; Boulton S; Huang J; Wang P; Chen H; Zhou J; Luchowska-Stańska U; Jentsch NG; Armstrong AL; Magolan J; Yarwood S; Melacini G
J Med Chem; 2020 May; 63(9):4762-4775. PubMed ID: 32297742
[TBL] [Abstract][Full Text] [Related]
2. Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.
Mazhab-Jafari MT; Das R; Fotheringham SA; SilDas S; Chowdhury S; Melacini G
J Am Chem Soc; 2007 Nov; 129(46):14482-92. PubMed ID: 17973384
[TBL] [Abstract][Full Text] [Related]
3. The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs).
Wiejak J; van Basten B; Luchowska-Stańska U; Hamilton G; Yarwood SJ
Biochim Biophys Acta Mol Cell Res; 2019 Feb; 1866(2):264-276. PubMed ID: 30414891
[TBL] [Abstract][Full Text] [Related]
4. Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.
Parnell E; McElroy SP; Wiejak J; Baillie GL; Porter A; Adams DR; Rehmann H; Smith BO; Yarwood SJ
Sci Rep; 2017 Mar; 7(1):294. PubMed ID: 28331191
[TBL] [Abstract][Full Text] [Related]
5. Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist.
Boulton S; Selvaratnam R; Blondeau JP; Lezoualc'h F; Melacini G
J Am Chem Soc; 2018 Aug; 140(30):9624-9637. PubMed ID: 30016089
[TBL] [Abstract][Full Text] [Related]
6. Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.
Beck EM; Parnell E; Cowley A; Porter A; Gillespie J; Robinson J; Robinson L; Pannifer AD; Hamon V; Jones P; Morrison A; McElroy S; Timmerman M; Rutjes H; Mahajan P; Wiejak J; Luchowska-Stańska U; Morgan D; Barker G; Rehmann H; Yarwood SJ
Cells; 2019 Nov; 8(11):. PubMed ID: 31726720
[TBL] [Abstract][Full Text] [Related]
7. Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling.
Wiejak J; van Basten B; Hamilton G; Yarwood SJ
Cells; 2019 Oct; 8(10):. PubMed ID: 31615122
[TBL] [Abstract][Full Text] [Related]
8. Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics.
Bufano M; Laudette M; Blondeau JP; Lezoualc'h F; Nalli M; Silvestri R; Brancale A; Coluccia A
J Comput Aided Mol Des; 2020 Nov; 34(11):1171-1179. PubMed ID: 32700175
[TBL] [Abstract][Full Text] [Related]
9. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.
Pereira L; Rehmann H; Lao DH; Erickson JR; Bossuyt J; Chen J; Bers DM
Proc Natl Acad Sci U S A; 2015 Mar; 112(13):3991-6. PubMed ID: 25829540
[TBL] [Abstract][Full Text] [Related]
10. The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.
Barker G; Parnell E; van Basten B; Buist H; Adams DR; Yarwood SJ
J Cardiovasc Dev Dis; 2017 Dec; 4(4):. PubMed ID: 29367551
[TBL] [Abstract][Full Text] [Related]
11. Structural dynamics in the activation of Epac.
Harper SM; Wienk H; Wechselberger RW; Bos JL; Boelens R; Rehmann H
J Biol Chem; 2008 Mar; 283(10):6501-8. PubMed ID: 18167352
[TBL] [Abstract][Full Text] [Related]
12. Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology.
White MA; Tsalkova T; Mei FC; Cheng X
Cells; 2019 Dec; 9(1):. PubMed ID: 31877746
[TBL] [Abstract][Full Text] [Related]
13. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
Gupta M; Yarwood SJ
J Biol Chem; 2005 Mar; 280(9):8109-16. PubMed ID: 15591041
[TBL] [Abstract][Full Text] [Related]
14. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Courilleau D; Bouyssou P; Fischmeister R; Lezoualc'h F; Blondeau JP
Biochem Biophys Res Commun; 2013 Oct; 440(3):443-8. PubMed ID: 24099776
[TBL] [Abstract][Full Text] [Related]
15. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.
Herfindal L; Nygaard G; Kopperud R; Krakstad C; Døskeland SO; Selheim F
Biochem Biophys Res Commun; 2013 Aug; 437(4):603-8. PubMed ID: 23850619
[TBL] [Abstract][Full Text] [Related]
16. cAMP-dependent allostery and dynamics in Epac: an NMR view.
Selvaratnam R; Akimoto M; VanSchouwen B; Melacini G
Biochem Soc Trans; 2012 Feb; 40(1):219-23. PubMed ID: 22260694
[TBL] [Abstract][Full Text] [Related]
17. The future of EPAC-targeted therapies: agonism versus antagonism.
Parnell E; Palmer TM; Yarwood SJ
Trends Pharmacol Sci; 2015 Apr; 36(4):203-14. PubMed ID: 25744542
[TBL] [Abstract][Full Text] [Related]
18. The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.
Selvaratnam R; VanSchouwen B; Fogolari F; Mazhab-Jafari MT; Das R; Melacini G
Biophys J; 2012 Feb; 102(3):630-9. PubMed ID: 22325287
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators.
Wang P; Luchowska-Stańska U; van Basten B; Chen H; Liu Z; Wiejak J; Whelan P; Morgan D; Lochhead E; Barker G; Rehmann H; Yarwood SJ; Zhou J
J Med Chem; 2020 May; 63(10):5159-5184. PubMed ID: 32340447
[TBL] [Abstract][Full Text] [Related]
20. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
Christensen AE; Selheim F; de Rooij J; Dremier S; Schwede F; Dao KK; Martinez A; Maenhaut C; Bos JL; Genieser HG; Døskeland SO
J Biol Chem; 2003 Sep; 278(37):35394-402. PubMed ID: 12819211
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
