195 related articles for article (PubMed ID: 32298120)
1. Discovery and Structure-Activity Relationship Study of (
Manz TD; Sivakumaren SC; Ferguson FM; Zhang T; Yasgar A; Seo HS; Ficarro SB; Card JD; Shim H; Miduturu CV; Simeonov A; Shen M; Marto JA; Dhe-Paganon S; Hall MD; Cantley LC; Gray NS
J Med Chem; 2020 May; 63(9):4880-4895. PubMed ID: 32298120
[TBL] [Abstract][Full Text] [Related]
2. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
Sharma LK; Leonardi R; Lin W; Boyd VA; Goktug A; Shelat AA; Chen T; Jackowski S; Rock CO
J Med Chem; 2015 Feb; 58(3):1563-8. PubMed ID: 25569308
[TBL] [Abstract][Full Text] [Related]
3. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
Sivakumaren SC; Shim H; Zhang T; Ferguson FM; Lundquist MR; Browne CM; Seo HS; Paddock MN; Manz TD; Jiang B; Hao MF; Krishnan P; Wang DG; Yang TJ; Kwiatkowski NP; Ficarro SB; Cunningham JM; Marto JA; Dhe-Paganon S; Cantley LC; Gray NS
Cell Chem Biol; 2020 May; 27(5):525-537.e6. PubMed ID: 32130941
[TBL] [Abstract][Full Text] [Related]
4. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey HK; Rooney TPC; Willems HMG; Edwards S; Green C; Howard T; Ogg D; Romero T; Scott DE; Winpenny D; Duce J; Skidmore J; Clarke JH; Andrews SP
J Med Chem; 2022 Feb; 65(4):3359-3370. PubMed ID: 35148092
[TBL] [Abstract][Full Text] [Related]
5. Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bataille CJ; Brennan MB; Byrne S; Davies SG; Durbin M; Fedorov O; Huber KV; Jones AM; Knapp S; Liu G; Nadali A; Quevedo CE; Russell AJ; Walker RG; Westwood R; Wynne GM
Bioorg Med Chem; 2017 May; 25(9):2657-2665. PubMed ID: 28341403
[TBL] [Abstract][Full Text] [Related]
6. Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C.
Wright BD; Simpson C; Stashko M; Kireev D; Hull-Ryde EA; Zylka MJ; Janzen WP
J Biomol Screen; 2015 Jun; 20(5):655-62. PubMed ID: 25534829
[TBL] [Abstract][Full Text] [Related]
7. Discovery of novel pyruvate dehydrogenase kinases inhibitors by screening of an in-house small molecule library for anti-lung cancer therapeutics.
Guo F; Zhao S; Li X
Bioorg Med Chem Lett; 2019 Jan; 29(2):291-296. PubMed ID: 30470491
[TBL] [Abstract][Full Text] [Related]
8. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Manz TD; Sivakumaren SC; Yasgar A; Hall MD; Davis MI; Seo HS; Card JD; Ficarro SB; Shim H; Marto JA; Dhe-Paganon S; Sasaki AT; Boxer MB; Simeonov A; Cantley LC; Shen M; Zhang T; Ferguson FM; Gray NS
ACS Med Chem Lett; 2020 Mar; 11(3):346-352. PubMed ID: 32184968
[TBL] [Abstract][Full Text] [Related]
9. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
Simard JR; Getlik M; Grütter C; Pawar V; Wulfert S; Rabiller M; Rauh D
J Am Chem Soc; 2009 Sep; 131(37):13286-96. PubMed ID: 19572644
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Blake JF; Gaudino JJ; De Meese J; Mohr P; Chicarelli M; Tian H; Garrey R; Thomas A; Siedem CS; Welch MB; Kolakowski G; Kaus R; Burkard M; Martinson M; Chen H; Dean B; Dudley DA; Gould SE; Pacheco P; Shahidi-Latham S; Wang W; West K; Yin J; Moffat J; Schwarz JB
Bioorg Med Chem Lett; 2014 Jun; 24(12):2635-9. PubMed ID: 24813737
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
Gu C; Stashko MA; Puhl-Rubio AC; Chakraborty M; Chakraborty A; Frye SV; Pearce KH; Wang X; Shears SB; Wang H
J Med Chem; 2019 Feb; 62(3):1443-1454. PubMed ID: 30624931
[TBL] [Abstract][Full Text] [Related]
12. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.
Okawa T; Aramaki Y; Yamamoto M; Kobayashi T; Fukumoto S; Toyoda Y; Henta T; Hata A; Ikeda S; Kaneko M; Hoffman ID; Sang BC; Zou H; Kawamoto T
J Med Chem; 2017 Aug; 60(16):6942-6990. PubMed ID: 28699740
[TBL] [Abstract][Full Text] [Related]
13. Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors.
Strätker K; Haidar S; Amesty Á; El-Awaad E; Götz C; Estévez-Braun A; Jose J
FEBS J; 2020 Jul; 287(14):3042-3064. PubMed ID: 31876381
[TBL] [Abstract][Full Text] [Related]
14. Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Willems HMG; Edwards S; Boffey HK; Chawner SJ; Green C; Romero T; Winpenny D; Skidmore J; Clarke JH; Andrews SP
RSC Med Chem; 2023 May; 14(5):934-946. PubMed ID: 37252102
[TBL] [Abstract][Full Text] [Related]
15. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
Jiang JK; Huang X; Shamim K; Patel PR; Lee A; Wang AQ; Nguyen K; Tawa G; Cuny GD; Yu PB; Zheng W; Xu X; Sanderson P; Huang W
Bioorg Med Chem Lett; 2018 Nov; 28(20):3356-3362. PubMed ID: 30227946
[TBL] [Abstract][Full Text] [Related]
17. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Terao Y; Suzuki H; Yoshikawa M; Yashiro H; Takekawa S; Fujitani Y; Okada K; Inoue Y; Yamamoto Y; Nakagawa H; Yao S; Kawamoto T; Uchikawa O
Bioorg Med Chem Lett; 2012 Dec; 22(24):7326-9. PubMed ID: 23147077
[TBL] [Abstract][Full Text] [Related]
18. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.
Patwardhan NN; Morris EA; Kharel Y; Raje MR; Gao M; Tomsig JL; Lynch KR; Santos WL
J Med Chem; 2015 Feb; 58(4):1879-1899. PubMed ID: 25643074
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
Shim J; Eid C; Lee J; Liu E; Chaudhary D; Boschelli DH
Bioorg Med Chem Lett; 2009 Dec; 19(23):6575-7. PubMed ID: 19854645
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors.
Arfeen M; Bhagat S; Patel R; Prasad S; Roy I; Chakraborti AK; Bharatam PV
Eur J Med Chem; 2016 Oct; 121():727-736. PubMed ID: 27423119
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]