BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 32307772)

  • 1. Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9-based screening system.
    Chiu YW; Hori Y; Ebinuma I; Sato H; Hara N; Ikeuchi T; Tomita T
    FASEB J; 2020 Jun; 34(6):7661-7674. PubMed ID: 32307772
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system].
    Tomizawa I; Chiu YW; Hori Y; Tomita T
    Nihon Yakurigaku Zasshi; 2023; 158(1):21-25. PubMed ID: 36596482
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
    Park HJ; Shabashvili D; Nekorchuk MD; Shyqyriu E; Jung JI; Ladd TB; Moore BD; Felsenstein KM; Golde TE; Kim SH
    J Biol Chem; 2012 Nov; 287(48):40629-40. PubMed ID: 23043097
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.
    Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
    Alzheimers Res Ther; 2017 Aug; 9(1):57. PubMed ID: 28764767
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.
    Tanabe C; Maeda T; Zou K; Liu J; Liu S; Nakajima T; Komano H
    J Biol Chem; 2012 Dec; 287(53):44203-11. PubMed ID: 23129766
    [TBL] [Abstract][Full Text] [Related]  

  • 6. RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity.
    Fang F; Yu Q; Arancio O; Chen D; Gore SS; Yan SS; Yan SF
    Hum Mol Genet; 2018 Mar; 27(6):1002-1014. PubMed ID: 29329433
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90.
    Noorani AA; Yamashita H; Gao Y; Islam S; Sun Y; Nakamura T; Enomoto H; Zou K; Michikawa M
    J Biol Chem; 2020 Dec; 295(52):18010-18022. PubMed ID: 33067321
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.
    Jung S; Nah J; Han J; Choi SG; Kim H; Park J; Pyo HK; Jung YK
    J Neurochem; 2016 Jun; 137(5):770-81. PubMed ID: 26924229
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.
    Sun Z; Xie Y; Chen Y; Yang Q; Quan Z; Dai R; Qing H
    Mol Neurobiol; 2018 May; 55(5):3841-3855. PubMed ID: 28547526
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.
    Winkler E; Kamp F; Scheuring J; Ebke A; Fukumori A; Steiner H
    J Biol Chem; 2012 Jun; 287(25):21326-34. PubMed ID: 22532566
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D; Kienlen-Campard P; Octave JN
    J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase.
    Walter J
    Neurodegener Dis; 2006; 3(4-5):247-54. PubMed ID: 17047364
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.
    Gwon AR; Park JS; Arumugam TV; Kwon YK; Chan SL; Kim SH; Baik SH; Yang S; Yun YK; Choi Y; Kim S; Tang SC; Hyun DH; Cheng A; Dann CE; Bernier M; Lee J; Markesbery WR; Mattson MP; Jo DG
    Aging Cell; 2012 Aug; 11(4):559-68. PubMed ID: 22404891
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.
    Mañucat-Tan NB; Saadipour K; Wang YJ; Bobrovskaya L; Zhou XF
    Mol Neurobiol; 2019 Feb; 56(2):812-830. PubMed ID: 29797184
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.
    Petit D; Hitzenberger M; Lismont S; Zoltowska KM; Ryan NS; Mercken M; Bischoff F; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2019 Jun; 38(12):. PubMed ID: 31109937
    [TBL] [Abstract][Full Text] [Related]  

  • 19. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
    Wang J; Lu R; Yang J; Li H; He Z; Jing N; Wang X; Wang Y
    Nat Commun; 2015 Nov; 6():8876. PubMed ID: 26581893
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.