114 related articles for article (PubMed ID: 32338509)
1. Computational Insights into Molecular Activation and Positive Cooperative Mechanisms of FFAR1 Modulators.
Teng D; Chen J; Li D; Wu Z; Li W; Tang Y; Liu G
J Chem Inf Model; 2020 Jun; 60(6):3214-3230. PubMed ID: 32338509
[TBL] [Abstract][Full Text] [Related]
2. Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics.
Atanasio S; Deganutti G; Reynolds CA
J Comput Aided Mol Des; 2020 Nov; 34(11):1181-1193. PubMed ID: 32851580
[TBL] [Abstract][Full Text] [Related]
3. Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus.
Rani L; Grewal AS; Sharma N; Singh S
Mini Rev Med Chem; 2021; 21(4):426-470. PubMed ID: 33100202
[TBL] [Abstract][Full Text] [Related]
4. Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.
Lückmann M; Trauelsen M; Bentsen MA; Nissen TAD; Martins J; Fallah Z; Nygaard MM; Papaleo E; Lindorff-Larsen K; Schwartz TW; Frimurer TM
Proc Natl Acad Sci U S A; 2019 Apr; 116(14):7123-7128. PubMed ID: 30872479
[TBL] [Abstract][Full Text] [Related]
5. Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations.
An X; Bai Q; Bing Z; Liu H; Yao X
Comput Struct Biotechnol J; 2021; 19():3978-3989. PubMed ID: 34377364
[TBL] [Abstract][Full Text] [Related]
6. Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.
Helal MA; Darwish KM; Hammad MA
Bioorg Med Chem Lett; 2014 Nov; 24(22):5330-6. PubMed ID: 25441945
[TBL] [Abstract][Full Text] [Related]
7. Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators.
Teng D; Zhou Y; Tang Y; Liu G; Tu Y
J Chem Inf Model; 2022 Aug; 62(15):3664-3675. PubMed ID: 35877470
[TBL] [Abstract][Full Text] [Related]
8. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity.
Governa P; Caroleo MC; Carullo G; Aiello F; Cione E; Manetti F
Bioorg Med Chem Lett; 2021 Jun; 41():127969. PubMed ID: 33771587
[TBL] [Abstract][Full Text] [Related]
9. Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.
Sum CS; Tikhonova IG; Costanzi S; Gershengorn MC
J Biol Chem; 2009 Feb; 284(6):3529-36. PubMed ID: 19068482
[TBL] [Abstract][Full Text] [Related]
10. Molecular mechanism of fatty acid activation of FFAR1.
Kumari P; Inoue A; Chapman K; Lian P; Rosenbaum DM
Proc Natl Acad Sci U S A; 2023 May; 120(22):e2219569120. PubMed ID: 37216523
[TBL] [Abstract][Full Text] [Related]
11. Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016-2019): a patent review.
Li Z; Zhou Z; Zhang L
Expert Opin Ther Pat; 2020 Jan; 30(1):27-38. PubMed ID: 31771391
[No Abstract] [Full Text] [Related]
12. Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.
Li Z; Xu X; Huang W; Qian H
Med Res Rev; 2018 Mar; 38(2):381-425. PubMed ID: 28328012
[TBL] [Abstract][Full Text] [Related]
13. Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution.
Yoshioka K; Yamashita H; Shimizu K; Shimomura S; Shibata T; Miyazaki JI; Honda H
Biochem Biophys Res Commun; 2021 Apr; 550():177-183. PubMed ID: 33706101
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists.
Darwish KM; Salama I; Mostafa S; Gomaa MS; Helal MA
Eur J Med Chem; 2016 Feb; 109():157-72. PubMed ID: 26774923
[TBL] [Abstract][Full Text] [Related]
15. An updated patent review of GPR40/ FFAR1 modulators (2020 - present).
Ren Q; Fan Y; Yang L; Shan M; Shi W; Qian H
Expert Opin Ther Pat; 2023; 33(9):565-577. PubMed ID: 37947382
[TBL] [Abstract][Full Text] [Related]
16. Molecular dynamics simulations reveal insights into key structural elements of adenosine receptors.
Rodríguez D; Piñeiro Á; Gutiérrez-de-Terán H
Biochemistry; 2011 May; 50(19):4194-208. PubMed ID: 21480628
[TBL] [Abstract][Full Text] [Related]
17. Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Lu J; Byrne N; Wang J; Bricogne G; Brown FK; Chobanian HR; Colletti SL; Di Salvo J; Thomas-Fowlkes B; Guo Y; Hall DL; Hadix J; Hastings NB; Hermes JD; Ho T; Howard AD; Josien H; Kornienko M; Lumb KJ; Miller MW; Patel SB; Pio B; Plummer CW; Sherborne BS; Sheth P; Souza S; Tummala S; Vonrhein C; Webb M; Allen SJ; Johnston JM; Weinglass AB; Sharma S; Soisson SM
Nat Struct Mol Biol; 2017 Jul; 24(7):570-577. PubMed ID: 28581512
[TBL] [Abstract][Full Text] [Related]
18. Recent Advances in Development of GPR40 Modulators (FFA1/FFAR1): An Emerging Target for Type 2 Diabetes.
Sharma N; Bhagat S; Chundawat TS
Mini Rev Med Chem; 2017; 17(11):947-958. PubMed ID: 28117025
[TBL] [Abstract][Full Text] [Related]
19. Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils.
Mena SJ; Manosalva C; Carretta MD; Teuber S; Olmo I; Burgos RA; Hidalgo MA
Innate Immun; 2016 Aug; 22(6):479-89. PubMed ID: 27363707
[TBL] [Abstract][Full Text] [Related]
20. Free fatty acid receptor 1 as a novel therapeutic target for type 2 diabetes mellitus-current status.
Eleazu C; Charles A; Eleazu K; Achi N
Chem Biol Interact; 2018 Jun; 289():32-39. PubMed ID: 29704509
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
