BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 32339392)

  • 1. Precision Medicine With Leflunomide: Consideration of the DHODH Haplotype and Plasma Teriflunomide Concentration and Modification of Outcomes in Patients With Rheumatoid Arthritis.
    Wiese MD; Hopkins AM; King C; Wechalekar MD; Lee A; Spargo L; Metcalf R; McWilliams L; Hill C; Cleland LG; Proudman SM
    Arthritis Care Res (Hoboken); 2021 Jul; 73(7):983-989. PubMed ID: 32339392
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Therapeutic response to leflunomide in combo therapy and monotherapy is associated to serum teriflunomide (A77 1726) levels.
    Fajardo-Robledo NS; Jacobo-Cuevas H; Perez-Guerrero EE; Corona-Sanchez EG; Saldaña-Cruz AM; Romero-Tejeda EM; Rodriguez-Jimenez NA; Totsuka-Sutto SE; Lopez-Roa RI; Ponce-Guarneros JM; Alcaraz-Lopez MF; Cerpa-Cruz S; Muñoz-Valle JF; Cardona-Muñoz EG; Gonzalez-Lopez L; Gamez-Nava JI;
    Sci Rep; 2022 Feb; 12(1):1877. PubMed ID: 35115601
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review.
    Kaur H; Sarma P; Bhattacharyya A; Sharma S; Chhimpa N; Prajapat M; Prakash A; Kumar S; Singh A; Singh R; Avti P; Thota P; Medhi B
    Eur J Pharmacol; 2021 Sep; 906():174233. PubMed ID: 34111397
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Safety, Pharmacokinetics, and Pharmacogenetics of Single-Dose Teriflunomide Sodium and Leflunomide in Healthy Chinese Subjects.
    Yao X; Wu Y; Jiang J; Hu P; Liu D; Chen X
    Clin Drug Investig; 2019 Jul; 39(7):643-651. PubMed ID: 31016613
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis.
    Hopkins AM; Wiese MD; Proudman SM; O'Doherty CE; Upton RN; Foster DJ
    Br J Clin Pharmacol; 2016 Jan; 81(1):113-23. PubMed ID: 26331989
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serum/Plasma.
    Rule GS; Rockwood AL; Johnson-Davis KL
    Methods Mol Biol; 2019; 1872():75-83. PubMed ID: 30350281
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis.
    O'Doherty C; Schnabl M; Spargo L; Cleland LG; James M; Proudman SM; Wiese MD
    Pharmacogenomics; 2012 Sep; 13(12):1427-34. PubMed ID: 22966891
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of a simple HPLC-MS/MS method to simultaneously determine teriflunomide and its metabolite in human plasma and urine: Application to clinical pharmacokinetic study of teriflunomide sodium and leflunomide.
    Yao X; Liu Y; Song L; Jiang J; Xiao F; Liu D; Hu P
    Biomed Chromatogr; 2019 Mar; 33(3):e4420. PubMed ID: 30362147
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors.
    Pontikos MA; Leija C; Zhao Z; Wang X; Kilgore J; Tornesi B; Adenmatten N; Phillips MA; Williams NS
    Biochem Pharmacol; 2022 Oct; 204():115237. PubMed ID: 36055381
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effect of the Intramolecular Hydrogen Bond on the Active Metabolite Analogs of Leflunomide for Blocking the Plasmodium falciparum Dihydroorotate Dehydrogenase Enzyme: QTAIM, NBO, and Docking Study.
    Heidarian R; Zahedi-Tabrizi M
    Curr Comput Aided Drug Des; 2021; 17(3):480-491. PubMed ID: 32459610
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study.
    Balagué C; Pont M; Prats N; Godessart N
    Br J Pharmacol; 2012 Jun; 166(4):1320-32. PubMed ID: 22229697
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Therapeutic drug monitoring of teriflunomide: do plasma concentrations predict response to leflunomide in patients with rheumatoid arthritis?
    Rawdha T; Aicha BT; Lobna BA; Issam S; Mouna BS; Olfa S; Selma B; Takoua BB; Kawther BA; Leila M; Hana S; Ines M; Leila A
    Drug Metab Pers Ther; 2023 Mar; 38(1):79-85. PubMed ID: 35998916
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Quantitation of Teriflunomide in Human Serum/Plasma Across a 40,000-Fold Concentration Range by LC/MS/MS.
    Rule GS; Rockwood AL; Johnson-Davis KL
    Methods Mol Biol; 2016; 1383():195-203. PubMed ID: 26660188
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Topical delivery of leflunomide for rheumatoid arthritis treatment: evaluation of local tissue deposition of teriflunomide and its anti-inflammatory effects in an arthritis rat model.
    Bae J; Park JW
    Drug Dev Ind Pharm; 2016; 42(2):254-62. PubMed ID: 26006334
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A population pharmacokinetic study to accelerate early phase clinical development for a novel drug, teriflunomide sodium, to treat systemic lupus erythematosus.
    Yao X; Wu Y; Jiang J; Chen X; Liu D; Hu P
    Eur J Pharm Sci; 2019 Aug; 136():104942. PubMed ID: 31154006
    [TBL] [Abstract][Full Text] [Related]  

  • 16. On the interactions of leflunomide and teriflunomide within receptor cavity--NMR studies and energy calculations.
    Kujawski J; Bernard MK; Jodłowska E; Czaja K; Drabińska B
    J Mol Model; 2015 May; 21(5):105. PubMed ID: 25851105
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide.
    Pawlik A; Herczynska M; Kurzawski M; Safranow K; Dziedziejko V; Drozdzik M
    Pharmacogenomics; 2009 Feb; 10(2):303-9. PubMed ID: 19207032
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.
    Jones SW; Penman SL; French NS; Park BK; Chadwick AE
    Toxicol In Vitro; 2021 Apr; 72():105096. PubMed ID: 33460737
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line.
    Adamczuk G; Humeniuk E; Iwan M; Natorska-Chomicka D; Adamczuk K; Korga-Plewko A
    Molecules; 2021 Sep; 26(18):. PubMed ID: 34577124
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Leflunomide in dialysis patients with rheumatoid arthritis--a pharmacokinetic study.
    Bergner R; Peters L; Schmitt V; Löffler C
    Clin Rheumatol; 2013 Feb; 32(2):267-70. PubMed ID: 23179005
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.