339 related articles for article (PubMed ID: 32354745)
1. Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid.
Subramanian K; Hutt DM; Scott SM; Gupta V; Mao S; Balch WE
J Biol Chem; 2020 Jun; 295(23):8017-8035. PubMed ID: 32354745
[TBL] [Abstract][Full Text] [Related]
2. Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.
Subramanian K; Rauniyar N; Lavalleé-Adam M; Yates JR; Balch WE
Mol Cell Proteomics; 2017 Nov; 16(11):1938-1957. PubMed ID: 28860124
[TBL] [Abstract][Full Text] [Related]
3. Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Pipalia NH; Cosner CC; Huang A; Chatterjee A; Bourbon P; Farley N; Helquist P; Wiest O; Maxfield FR
Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5620-5. PubMed ID: 21436030
[TBL] [Abstract][Full Text] [Related]
4. Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
Ashikawa H; Mogi H; Honda T; Nakamura H; Murayama T
Eur J Pharmacol; 2021 Apr; 896():173907. PubMed ID: 33503462
[TBL] [Abstract][Full Text] [Related]
5. Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.
Pipalia NH; Subramanian K; Mao S; Ralph H; Hutt DM; Scott SM; Balch WE; Maxfield FR
J Lipid Res; 2017 Apr; 58(4):695-708. PubMed ID: 28193631
[TBL] [Abstract][Full Text] [Related]
6. HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts.
Pipalia NH; Saad SZ; Subramanian K; Cross A; Al-Motawa A; Garg K; Blagg BSJ; Neckers L; Helquist P; Wiest O; Ory DS; Maxfield FR
J Lipid Res; 2021; 62():100114. PubMed ID: 34481829
[TBL] [Abstract][Full Text] [Related]
7. Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.
Singhal A; Szente L; Hildreth JEK; Song B
Cell Death Dis; 2018 Oct; 9(10):1019. PubMed ID: 30282967
[TBL] [Abstract][Full Text] [Related]
8. Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.
Gelsthorpe ME; Baumann N; Millard E; Gale SE; Langmade SJ; Schaffer JE; Ory DS
J Biol Chem; 2008 Mar; 283(13):8229-36. PubMed ID: 18216017
[TBL] [Abstract][Full Text] [Related]
9. Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Watari H; Blanchette-Mackie EJ; Dwyer NK; Glick JM; Patel S; Neufeld EB; Brady RO; Pentchev PG; Strauss JF
Proc Natl Acad Sci U S A; 1999 Feb; 96(3):805-10. PubMed ID: 9927649
[TBL] [Abstract][Full Text] [Related]
10. Defective cholesterol traffic and neuronal differentiation in neural stem cells of Niemann-Pick type C disease improved by valproic acid, a histone deacetylase inhibitor.
Kim SJ; Lee BH; Lee YS; Kang KS
Biochem Biophys Res Commun; 2007 Aug; 360(3):593-9. PubMed ID: 17624314
[TBL] [Abstract][Full Text] [Related]
11. Normalization of Hepatic Homeostasis in the
Munkacsi AB; Hammond N; Schneider RT; Senanayake DS; Higaki K; Lagutin K; Bloor SJ; Ory DS; Maue RA; Chen FW; Hernandez-Ono A; Dahlson N; Repa JJ; Ginsberg HN; Ioannou YA; Sturley SL
J Biol Chem; 2017 Mar; 292(11):4395-4410. PubMed ID: 28031458
[TBL] [Abstract][Full Text] [Related]
12. High-content screen for modifiers of Niemann-Pick type C disease in patient cells.
Pugach EK; Feltes M; Kaufman RJ; Ory DS; Bang AG
Hum Mol Genet; 2018 Jun; 27(12):2101-2112. PubMed ID: 29659804
[TBL] [Abstract][Full Text] [Related]
13. Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
Ilnytska O; Lai K; Gorshkov K; Schultz ML; Tran BN; Jeziorek M; Kunkel TJ; Azaria RD; McLoughlin HS; Waghalter M; Xu Y; Schlame M; Altan-Bonnet N; Zheng W; Lieberman AP; Dobrowolski R; Storch J
J Biol Chem; 2021 Jul; 297(1):100813. PubMed ID: 34023384
[TBL] [Abstract][Full Text] [Related]
14. Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice.
Peake KB; Vance JE
J Biol Chem; 2012 Mar; 287(12):9290-8. PubMed ID: 22277650
[TBL] [Abstract][Full Text] [Related]
15. Different Trafficking Phenotypes of Niemann-Pick C1 Gene Mutations Correlate with Various Alterations in Lipid Storage, Membrane Composition and Miglustat Amenability.
Brogden G; Shammas H; Walters F; Maalouf K; Das AM; Naim HY; Rizk S
Int J Mol Sci; 2020 Mar; 21(6):. PubMed ID: 32204338
[TBL] [Abstract][Full Text] [Related]
16. An induced pluripotent stem cell line (TRNDi001-D) from a Niemann-Pick disease type C1 (NPC1) patient carrying a homozygous p. I1061T (c. 3182T>C) mutation in the NPC1 gene.
Li R; Pradhan M; Xu M; Roeder A; Beers J; Zou J; Liu C; Porter FD; Zheng W
Stem Cell Res; 2020 Apr; 44():101737. PubMed ID: 32114296
[TBL] [Abstract][Full Text] [Related]
17. Quantitative Proteomics of Human Fibroblasts with I1061T Mutation in Niemann-Pick C1 (NPC1) Protein Provides Insights into the Disease Pathogenesis.
Rauniyar N; Subramanian K; Lavallée-Adam M; Martínez-Bartolomé S; Balch WE; Yates JR
Mol Cell Proteomics; 2015 Jul; 14(7):1734-49. PubMed ID: 25873482
[TBL] [Abstract][Full Text] [Related]
18. FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Newton J; Hait NC; Maceyka M; Colaco A; Maczis M; Wassif CA; Cougnoux A; Porter FD; Milstien S; Platt N; Platt FM; Spiegel S
FASEB J; 2017 Apr; 31(4):1719-1730. PubMed ID: 28082351
[TBL] [Abstract][Full Text] [Related]
19. Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process.
Wang C; Scott SM; Subramanian K; Loguercio S; Zhao P; Hutt DM; Farhat NY; Porter FD; Balch WE
Nat Commun; 2019 Nov; 10(1):5052. PubMed ID: 31699992
[TBL] [Abstract][Full Text] [Related]
20. Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.
Sun X; Marks DL; Park WD; Wheatley CL; Puri V; O'Brien JF; Kraft DL; Lundquist PA; Patterson MC; Pagano RE; Snow K
Am J Hum Genet; 2001 Jun; 68(6):1361-72. PubMed ID: 11349231
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]