BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

330 related articles for article (PubMed ID: 32430033)

  • 1. γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
    Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
    Alzheimers Res Ther; 2020 May; 12(1):61. PubMed ID: 32430033
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
    J Biol Chem; 2019 Jul; 294(29):11276-11285. PubMed ID: 31167792
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
    Jung JI; Ran Y; Cruz PE; Rosario AM; Ladd TB; Kukar TL; Koo EH; Felsenstein KM; Golde TE
    Biochemistry; 2014 Apr; 53(12):1947-57. PubMed ID: 24620716
    [TBL] [Abstract][Full Text] [Related]  

  • 4. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
    Lessard CB; Cottrell BA; Maruyama H; Suresh S; Golde TE; Koo EH
    PLoS One; 2015; 10(12):e0144758. PubMed ID: 26678856
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development and mechanism of γ-secretase modulators for Alzheimer's disease.
    Crump CJ; Johnson DS; Li YM
    Biochemistry; 2013 May; 52(19):3197-216. PubMed ID: 23614767
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA; Schenk DB; Basi GS
    Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 11. γ-Secretase in Alzheimer's disease.
    Hur JY
    Exp Mol Med; 2022 Apr; 54(4):433-446. PubMed ID: 35396575
    [TBL] [Abstract][Full Text] [Related]  

  • 12. γ-Secretase inhibitors and modulators.
    Golde TE; Koo EH; Felsenstein KM; Osborne BA; Miele L
    Biochim Biophys Acta; 2013 Dec; 1828(12):2898-907. PubMed ID: 23791707
    [TBL] [Abstract][Full Text] [Related]  

  • 13. γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
    Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlström H
    J Cell Mol Med; 2022 Feb; 26(3):880-892. PubMed ID: 34931449
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
    Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
    FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
    Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
    [TBL] [Abstract][Full Text] [Related]  

  • 16. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.
    Borgegard T; Juréus A; Olsson F; Rosqvist S; Sabirsh A; Rotticci D; Paulsen K; Klintenberg R; Yan H; Waldman M; Stromberg K; Nord J; Johansson J; Regner A; Parpal S; Malinowsky D; Radesater AC; Li T; Singh R; Eriksson H; Lundkvist J
    J Biol Chem; 2012 Apr; 287(15):11810-9. PubMed ID: 22334705
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
    Page RM; Gutsmiedl A; Fukumori A; Winkler E; Haass C; Steiner H
    J Biol Chem; 2010 Jun; 285(23):17798-810. PubMed ID: 20348104
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.
    Wanngren J; Ottervald J; Parpal S; Portelius E; Strömberg K; Borgegård T; Klintenberg R; Juréus A; Blomqvist J; Blennow K; Zetterberg H; Lundkvist J; Rosqvist S; Karlström H
    J Biol Chem; 2012 Sep; 287(39):32640-50. PubMed ID: 22851182
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.