331 related articles for article (PubMed ID: 32430033)
21. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
22. Novel γ-secretase enzyme modulators directly target presenilin protein.
Ebke A; Luebbers T; Fukumori A; Shirotani K; Haass C; Baumann K; Steiner H
J Biol Chem; 2011 Oct; 286(43):37181-6. PubMed ID: 21896486
[TBL] [Abstract][Full Text] [Related]
23. Presenilin is the molecular target of acidic γ-secretase modulators in living cells.
Jumpertz T; Rennhack A; Ness J; Baches S; Pietrzik CU; Bulic B; Weggen S
PLoS One; 2012; 7(1):e30484. PubMed ID: 22238696
[TBL] [Abstract][Full Text] [Related]
24. Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.
Li T; Huang Y; Jin S; Ye L; Rong N; Yang X; Ding Y; Cheng Z; Zhang J; Wan Z; Harrison DC; Hussain I; Hall A; Lee DH; Lau LF; Matsuoka Y
J Neurochem; 2012 Apr; 121(2):277-86. PubMed ID: 22035227
[TBL] [Abstract][Full Text] [Related]
25. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
26. Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.
Barthet G; Shioi J; Shao Z; Ren Y; Georgakopoulos A; Robakis NK
FASEB J; 2011 Sep; 25(9):2937-46. PubMed ID: 21597003
[TBL] [Abstract][Full Text] [Related]
27. Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.
Cai T; Yonaga M; Tomita T
J Neurosci; 2017 Dec; 37(50):12272-12280. PubMed ID: 29118109
[TBL] [Abstract][Full Text] [Related]
28. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S
J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478
[TBL] [Abstract][Full Text] [Related]
29. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
30. Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD-Linked Presenilin to Screen Mutations and γ-Secretase Modulators.
Futai E
Methods Mol Biol; 2019; 2049():403-417. PubMed ID: 31602624
[TBL] [Abstract][Full Text] [Related]
31. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
eNeuro; 2021; 8(2):. PubMed ID: 33608391
[TBL] [Abstract][Full Text] [Related]
32. The catalytic core of gamma-secretase: presenilin revisited.
Steiner H
Curr Alzheimer Res; 2008 Apr; 5(2):147-57. PubMed ID: 18393799
[TBL] [Abstract][Full Text] [Related]
33. An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates.
McKee TD; Loureiro RM; Dumin JA; Zarayskiy V; Tate B
J Neurosci Methods; 2013 Feb; 213(1):14-21. PubMed ID: 23219895
[TBL] [Abstract][Full Text] [Related]
34. Substrate-targeting gamma-secretase modulators.
Kukar TL; Ladd TB; Bann MA; Fraering PC; Narlawar R; Maharvi GM; Healy B; Chapman R; Welzel AT; Price RW; Moore B; Rangachari V; Cusack B; Eriksen J; Jansen-West K; Verbeeck C; Yager D; Eckman C; Ye W; Sagi S; Cottrell BA; Torpey J; Rosenberry TL; Fauq A; Wolfe MS; Schmidt B; Walsh DM; Koo EH; Golde TE
Nature; 2008 Jun; 453(7197):925-9. PubMed ID: 18548070
[TBL] [Abstract][Full Text] [Related]
35. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
36. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
[TBL] [Abstract][Full Text] [Related]
37. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
[TBL] [Abstract][Full Text] [Related]
38. Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF; Bursavich MG; Freeman EA; Hrdlicka LA; Hodgdon HE; Chen T; Costa DE; Harrison BA; Kapadnis S; Murphy DA; Nolan S; Tu Z; Tang C; Burnett DA; Patzke H; Koenig G
Alzheimers Res Ther; 2016 Aug; 8(1):34. PubMed ID: 27572246
[TBL] [Abstract][Full Text] [Related]
39. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
40. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
Okochi M; Tagami S; Yanagida K; Takami M; Kodama TS; Mori K; Nakayama T; Ihara Y; Takeda M
Cell Rep; 2013 Jan; 3(1):42-51. PubMed ID: 23291095
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]