BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 32430490)

  • 21. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
    Li TK; Houghton PJ; Desai SD; Daroui P; Liu AA; Hars ES; Ruchelman AL; LaVoie EJ; Liu LF
    Cancer Res; 2003 Dec; 63(23):8400-7. PubMed ID: 14679002
    [TBL] [Abstract][Full Text] [Related]  

  • 22. New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis.
    Tian QT; Ding CY; Song SS; Wang YQ; Zhang A; Miao ZH
    Biochem Pharmacol; 2018 Aug; 154():255-264. PubMed ID: 29753750
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.
    Beck DE; Lv W; Abdelmalak M; Plescia CB; Agama K; Marchand C; Pommier Y; Cushman M
    Bioorg Med Chem; 2016 Apr; 24(7):1469-79. PubMed ID: 26906474
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.
    Zhao H; Rybak P; Dobrucki J; Traganos F; Darzynkiewicz Z
    Cytometry A; 2012 Jan; 81(1):45-51. PubMed ID: 22140093
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
    Kinders RJ; Hollingshead M; Lawrence S; Ji J; Tabb B; Bonner WM; Pommier Y; Rubinstein L; Evrard YA; Parchment RE; Tomaszewski J; Doroshow JH;
    Clin Cancer Res; 2010 Nov; 16(22):5447-57. PubMed ID: 20924131
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.
    Yu CC; Pan SL; Chao SW; Liu SP; Hsu JL; Yang YC; Li TK; Huang WJ; Guh JH
    Biochem Pharmacol; 2014 Aug; 90(3):320-30. PubMed ID: 24915421
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: importance of DNA replication, repair and cell cycle checkpoints.
    Pommier Y
    Curr Med Chem Anticancer Agents; 2004 Sep; 4(5):429-34. PubMed ID: 15379698
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant
    Lee HM; Clark EP; Kuijer MB; Cushman M; Pommier Y; Philpot BD
    Mol Autism; 2018; 9():45. PubMed ID: 30140420
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
    Laev SS; Salakhutdinov NF; Lavrik OI
    Bioorg Med Chem; 2016 Nov; 24(21):5017-5027. PubMed ID: 27687971
    [TBL] [Abstract][Full Text] [Related]  

  • 30. BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.
    Coussy F; El-Botty R; Château-Joubert S; Dahmani A; Montaudon E; Leboucher S; Morisset L; Painsec P; Sourd L; Huguet L; Nemati F; Servely JL; Larcher T; Vacher S; Briaux A; Reyes C; La Rosa P; Lucotte G; Popova T; Foidart P; Sounni NE; Noel A; Decaudin D; Fuhrmann L; Salomon A; Reyal F; Mueller C; Ter Brugge P; Jonkers J; Poupon MF; Stern MH; Bièche I; Pommier Y; Marangoni E
    Sci Transl Med; 2020 Feb; 12(531):. PubMed ID: 32075943
    [TBL] [Abstract][Full Text] [Related]  

  • 31. ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
    Jossé R; Martin SE; Guha R; Ormanoglu P; Pfister TD; Reaper PM; Barnes CS; Jones J; Charlton P; Pollard JR; Morris J; Doroshow JH; Pommier Y
    Cancer Res; 2014 Dec; 74(23):6968-79. PubMed ID: 25269479
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.
    Cushman M; Jayaraman M; Vroman JA; Fukunaga AK; Fox BM; Kohlhagen G; Strumberg D; Pommier Y
    J Med Chem; 2000 Oct; 43(20):3688-98. PubMed ID: 11020283
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Characterisation of a human small-cell lung cancer cell line resistant to the DNA topoisomerase I-directed drug topotecan.
    Sorensen M; Sehested M; Jensen PB
    Br J Cancer; 1995 Aug; 72(2):399-404. PubMed ID: 7640225
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.
    Nguyen TX; Abdelmalak M; Marchand C; Agama K; Pommier Y; Cushman M
    J Med Chem; 2015 Apr; 58(7):3188-208. PubMed ID: 25811317
    [TBL] [Abstract][Full Text] [Related]  

  • 35. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
    Zeng Z; Cortés-Ledesma F; El Khamisy SF; Caldecott KW
    J Biol Chem; 2011 Jan; 286(1):403-9. PubMed ID: 21030584
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study.
    Tesauro C; Simonsen AK; Andersen MB; Petersen KW; Kristoffersen EL; Algreen L; Hansen NY; Andersen AB; Jakobsen AK; Stougaard M; Gromov P; Knudsen BR; Gromova I
    BMC Cancer; 2019 Nov; 19(1):1158. PubMed ID: 31783818
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
    Tsuda M; Kitamasu K; Hosokawa S; Nakano T; Ide H
    Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):170-184. PubMed ID: 31608820
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
    Morrell A; Jayaraman M; Nagarajan M; Fox BM; Meckley MR; Ioanoviciu A; Pommier Y; Antony S; Hollingshead M; Cushman M
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4395-9. PubMed ID: 16750365
    [TBL] [Abstract][Full Text] [Related]  

  • 39. [Molecular determinants of response to topoisomerase I inhibitors].
    Pourquier P; Lansiaux A
    Bull Cancer; 2011 Nov; 98(11):1287-98. PubMed ID: 22049384
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells.
    Jacob S; Aguado M; Fallik D; Praz F
    Cancer Res; 2001 Sep; 61(17):6555-62. PubMed ID: 11522654
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.