These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
213 related articles for article (PubMed ID: 32439807)
21. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882 [TBL] [Abstract][Full Text] [Related]
22. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ. Olsson RI; Xue Y; von Berg S; Aagaard A; McPheat J; Hansson EL; Bernström J; Hansson P; Jirholt J; Grindebacke H; Leffler A; Chen R; Xiong Y; Ge H; Hansson TG; Narjes F ChemMedChem; 2016 Jan; 11(2):207-16. PubMed ID: 26553345 [TBL] [Abstract][Full Text] [Related]
23. Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site. Meijer FA; van den Oetelaar MCM; Doveston RG; Sampers ENR; Brunsveld L ACS Med Chem Lett; 2021 Apr; 12(4):631-639. PubMed ID: 33854703 [TBL] [Abstract][Full Text] [Related]
24. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. Sun N; Ma X; Zhou K; Zhu C; Cao Z; Wang Y; Xu J; Fu W Eur J Med Chem; 2020 Feb; 187():111984. PubMed ID: 31881455 [TBL] [Abstract][Full Text] [Related]
25. Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist. Shibata A; Uga K; Sato T; Sagara M; Igaki K; Nakamura Y; Ochida A; Kono M; Shirai J; Yamamoto S; Yamasaki M; Tsuchimori N Biochem Pharmacol; 2018 Apr; 150():35-45. PubMed ID: 29369782 [TBL] [Abstract][Full Text] [Related]
26. Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. Kallen J; Izaac A; Be C; Arista L; Orain D; Kaupmann K; Guntermann C; Hoegenauer K; Hintermann S ChemMedChem; 2017 Jul; 12(13):1014-1021. PubMed ID: 28590087 [TBL] [Abstract][Full Text] [Related]
27. Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt. Gege C; Albers M; Kinzel O; Kleymann G; Schlüter T; Steeneck C; Hoffmann T; Xue X; Cummings MD; Spurlino J; Milligan C; Fourie AM; Edwards JP; Leonard K; Coe K; Scott B; Pippel D; Goldberg SD Bioorg Med Chem Lett; 2020 Jun; 30(12):127205. PubMed ID: 32336498 [TBL] [Abstract][Full Text] [Related]
28. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Soroosh P; Wu J; Xue X; Song J; Sutton SW; Sablad M; Yu J; Nelen MI; Liu X; Castro G; Luna R; Crawford S; Banie H; Dandridge RA; Deng X; Bittner A; Kuei C; Tootoonchi M; Rozenkrants N; Herman K; Gao J; Yang XV; Sachen K; Ngo K; Fung-Leung WP; Nguyen S; de Leon-Tabaldo A; Blevitt J; Zhang Y; Cummings MD; Rao T; Mani NS; Liu C; McKinnon M; Milla ME; Fourie AM; Sun S Proc Natl Acad Sci U S A; 2014 Aug; 111(33):12163-8. PubMed ID: 25092323 [TBL] [Abstract][Full Text] [Related]
29. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists. Wang Y; Yang T; Liu Q; Ma Y; Yang L; Zhou L; Xiang Z; Cheng Z; Lu S; Orband-Miller LA; Zhang W; Wu Q; Zhang K; Li Y; Xiang JN; Elliott JD; Leung S; Ren F; Lin X Bioorg Med Chem; 2015 Sep; 23(17):5293-302. PubMed ID: 26277758 [TBL] [Abstract][Full Text] [Related]
30. Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists. Ma X; Sun N; Li X; Fu W Eur J Med Chem; 2021 Oct; 222():113585. PubMed ID: 34118722 [TBL] [Abstract][Full Text] [Related]
31. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Tan J; Liu H; Huang M; Li N; Tang S; Meng J; Tang S; Zhou H; Kijlstra A; Yang P; Hou S Cell Death Dis; 2020 Aug; 11(8):697. PubMed ID: 32829384 [TBL] [Abstract][Full Text] [Related]
32. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses. Ecoeur F; Weiss J; Kaupmann K; Hintermann S; Orain D; Guntermann C Front Immunol; 2019; 10():577. PubMed ID: 30972071 [TBL] [Abstract][Full Text] [Related]
33. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity. Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824 [TBL] [Abstract][Full Text] [Related]
34. Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of Psoriasis. Tang L; Yang X; Liang Y; Xie H; Dai Z; Zheng G Front Immunol; 2018; 9():1210. PubMed ID: 29899748 [TBL] [Abstract][Full Text] [Related]
35. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production. Fujita-Sato S; Ito S; Isobe T; Ohyama T; Wakabayashi K; Morishita K; Ando O; Isono F J Biol Chem; 2011 Sep; 286(36):31409-17. PubMed ID: 21733845 [TBL] [Abstract][Full Text] [Related]
36. Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation. Sun N; Yuan C; Ma X; Wang Y; Gu X; Fu W Molecules; 2018 Dec; 23(12):. PubMed ID: 30513894 [TBL] [Abstract][Full Text] [Related]
37. Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt. Kummer DA; Cummings MD; Abad M; Barbay J; Castro G; Wolin R; Kreutter KD; Maharoof U; Milligan C; Nishimura R; Pierce J; Schalk-Hihi C; Spurlino J; Urbanski M; Venkatesan H; Wang A; Woods C; Xue X; Edwards JP; Fourie AM; Leonard K Bioorg Med Chem Lett; 2017 May; 27(9):2047-2057. PubMed ID: 28318945 [TBL] [Abstract][Full Text] [Related]
38. (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease. Jetten AM; Cook DN Annu Rev Pharmacol Toxicol; 2020 Jan; 60():371-390. PubMed ID: 31386594 [TBL] [Abstract][Full Text] [Related]
39. Discovery of carbazole carboxamides as novel RORγt inverse agonists. Huang Y; Yu M; Sun N; Tang T; Yu F; Song X; Xie Q; Fu W; Shao L; Wang Y Eur J Med Chem; 2018 Mar; 148():465-476. PubMed ID: 29477887 [TBL] [Abstract][Full Text] [Related]
40. In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists. Skepner J; Trocha M; Ramesh R; Qu XA; Schmidt D; Baloglu E; Lobera M; Davis S; Nolan MA; Carlson TJ; Hill J; Ghosh S; Sundrud MS; Yang J Immunology; 2015 Jul; 145(3):347-56. PubMed ID: 25604624 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]