BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

135 related articles for article (PubMed ID: 32442850)

  • 1. Privileged scaffold-based design to identify a novel drug-like 5-HT
    Lacivita E; Niso M; Stama ML; Arzuaga A; Altamura C; Costa L; Desaphy JF; Ragozzino ME; Ciranna L; Leopoldo M
    Eur J Med Chem; 2020 Aug; 199():112395. PubMed ID: 32442850
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.
    Lacivita E; Podlewska S; Speranza L; Niso M; Satała G; Perrone R; Perrone-Capano C; Bojarski AJ; Leopoldo M
    Eur J Med Chem; 2016 Sep; 120():363-79. PubMed ID: 27318552
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models.
    Canal CE; Felsing DE; Liu Y; Zhu W; Wood JT; Perry CK; Vemula R; Booth RG
    ACS Chem Neurosci; 2015 Jul; 6(7):1259-70. PubMed ID: 26011730
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.
    Lacivita E; De Giorgio P; Patarnello D; Niso M; Colabufo NA; Berardi F; Perrone R; Satala G; Duszynska B; Bojarski AJ; Leopoldo M
    Exp Brain Res; 2013 Oct; 230(4):569-82. PubMed ID: 23571499
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.
    Spadoni G; Bedini A; Bartolucci S; Pala D; Mor M; Riccioni T; Borsini F; Cabri W; Celona D; Marzi M; Tarzia G; Rivara S; Minetti P
    Eur J Med Chem; 2014 Jun; 80():8-35. PubMed ID: 24763360
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.
    López-Rodríguez ML; Morcillo MJ; Fernández E; Benhamú B; Tejada I; Ayala D; Viso A; Olivella M; Pardo L; Delgado M; Manzanares J; Fuentes JA
    Bioorg Med Chem Lett; 2003 Apr; 13(8):1429-32. PubMed ID: 12668005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.
    Canale V; Guzik P; Kurczab R; Verdie P; Satała G; Kubica B; Pawłowski M; Martinez J; Subra G; Bojarski AJ; Zajdel P
    Eur J Med Chem; 2014 May; 78():10-22. PubMed ID: 24675176
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
    Lacivita E; Patarnello D; Stroth N; Caroli A; Niso M; Contino M; De Giorgio P; Di Pilato P; Colabufo NA; Berardi F; Perrone R; Svenningsson P; Hedlund PB; Leopoldo M
    J Med Chem; 2012 Jul; 55(14):6375-80. PubMed ID: 22738316
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MF-8, a novel promising arylpiperazine-hydantoin based 5-HT
    Latacz G; Lubelska A; Jastrzębska-Więsek M; Partyka A; Kucwaj-Brysz K; Wesołowska A; Kieć-Kononowicz K; Handzlik J
    Bioorg Med Chem Lett; 2018 Mar; 28(5):878-883. PubMed ID: 29439902
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands.
    Rague A; Tidgewell K
    Mini Rev Med Chem; 2018; 18(7):552-560. PubMed ID: 28901854
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-activity relationship studies of CNS agents, Part 32: Effect of structural modifications in 1-arylpiperazine derivatives on alpha(1) -adrenoreceptor affinity.
    Mokrosz MJ; Paluchowska MH; Charakchieva-Minol S; Bień A
    Arch Pharm (Weinheim); 1997 Jun; 330(6):177-80. PubMed ID: 9264242
    [TBL] [Abstract][Full Text] [Related]  

  • 12. trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
    Perrone R; Berardi F; Colabufo NA; Leopoldo M; Lacivita E; Tortorella V; Leonardi A; Poggesi E; Testa R
    J Med Chem; 2001 Dec; 44(25):4431-42. PubMed ID: 11728188
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT
    Intagliata S; Modica MN; Pittalà V; Salerno L; Siracusa MA; Cagnotto A; Salmona M; Kurczab R; Romeo G
    Bioorg Med Chem; 2017 Feb; 25(3):1250-1259. PubMed ID: 28063784
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
    Modica MN; Intagliata S; Pittalà V; Salerno L; Siracusa MA; Cagnotto A; Salmona M; Romeo G
    Bioorg Med Chem Lett; 2015 Apr; 25(7):1427-30. PubMed ID: 25759032
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.
    Canale V; Kurczab R; Partyka A; Satała G; Witek J; Jastrzębska-Więsek M; Pawłowski M; Bojarski AJ; Wesołowska A; Zajdel P
    Eur J Med Chem; 2015 Mar; 92():202-11. PubMed ID: 25555143
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder.
    Lacivita E; Niso M; Mastromarino M; Garcia Silva A; Resch C; Zeug A; Loza MI; Castro M; Ponimaskin E; Leopoldo M
    ACS Chem Neurosci; 2021 Apr; 12(8):1313-1327. PubMed ID: 33792287
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
    Costa L; Sardone LM; Lacivita E; Leopoldo M; Ciranna L
    Front Behav Neurosci; 2015; 9():65. PubMed ID: 25814945
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
    Lacivita E; Di Pilato P; Stama ML; Colabufo NA; Berardi F; Perrone R; De Filippis B; Laviola G; Adriani W; Niso M; Leopoldo M
    Bioorg Med Chem Lett; 2013 Nov; 23(22):6083-6. PubMed ID: 24100077
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT
    Chłoń-Rzepa G; Zagórska A; Żmudzki P; Bucki A; Kołaczkowski M; Partyka A; Wesołowska A; Kazek G; Głuch-Lutwin M; Siwek A; Starowicz G; Pawłowski M
    Arch Pharm (Weinheim); 2016 Dec; 349(12):889-903. PubMed ID: 27869315
    [TBL] [Abstract][Full Text] [Related]  

  • 20. N4-unsubstituted N1-arylpiperazines as high-affinity 5-HT1A receptor ligands.
    Kuipers W; van Wijngaarden I; Kruse CG; ter Horst-van Amstel M; Tulp MT; IJzerman AP
    J Med Chem; 1995 May; 38(11):1942-54. PubMed ID: 7783126
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.